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Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment
Wang, Pan1,2; Zhou, Bo1; Yao, Hongxiang3; Zhan, Yafeng4,5; Zhang, Zengqiang1,6; Cui, Yue4,7; Xu, Kaibin4,7; Ma, Jianhua5; Wang, Luning1; An, Ningyu3; Zhang, Xi1; Liu, Yong4,7; Jiang, Tianzi4,7,8; Yong Liu
2015-10-06
发表期刊SCIENTIFIC REPORTS
卷号5期号:6页码:1-12
文章类型Article
摘要Alzheimer's disease (AD) patients and those with high-risk mild cognitive impairment are increasingly considered to have dysfunction syndromes. Large-scale network studies based on neuroimaging techniques may provide additional insight into AD pathophysiology. The aim of the present study is to evaluate the impaired network functional connectivity with the disease progression. For this purpose, we explored altered functional connectivities based on previously well-defined brain areas that comprise the five key functional systems [the default mode network (DMN), dorsal attention network (DAN), control network (CON), salience network (SAL), sensorimotor network (SMN)] in 35 with AD and 27 with mild cognitive impairment (MCI) subjects, compared with 27 normal cognitive subjects. Based on three levels of analysis, we found that intra-and inter-network connectivity were impaired in AD. Importantly, the interaction between the sensorimotor and attention functions was first attacked at the MCI stage and then extended to the key functional systems in the AD individuals. Lower cognitive ability (lower MMSE scores) was significantly associated with greater reductions in intra-and inter-network connectivity across all patient groups. These profiles indicate that aberrant intra-and inter-network dysfunctions might be potential biomarkers or predictors of AD progression and provide new insight into AD pathophysiology.
关键词Default-mode Network
WOS标题词Science & Technology
DOI10.1038/srep14824
关键词[WOS]DEFAULT-MODE NETWORK ; RESTING-STATE FMRI ; ALTERED FUNCTIONAL CONNECTIVITY ; ASSOCIATION WORKGROUPS ; DIAGNOSTIC GUIDELINES ; NATIONAL INSTITUTE ; EXECUTIVE FUNCTION ; AMYLOID BURDEN ; DISCONNECTION SYNDROME ; SALIENCE NETWORK
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000362278500001
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10030
专题脑网络组研究中心
通讯作者Yong Liu
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Dept Neurol, Beijing 100853, Peoples R China
2.Tianjin Huanhu Hosp, Dept Neurol, Tianjin 300060, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
5.Southern Med Univ, Sch Biomed Engn, Guangzhou 510515, Guangdong, Peoples R China
6.Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Sanya 572014, Peoples R China
7.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
8.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing 100190, Peoples R China
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Wang, Pan,Zhou, Bo,Yao, Hongxiang,et al. Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment[J]. SCIENTIFIC REPORTS,2015,5(6):1-12.
APA Wang, Pan.,Zhou, Bo.,Yao, Hongxiang.,Zhan, Yafeng.,Zhang, Zengqiang.,...&Yong Liu.(2015).Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment.SCIENTIFIC REPORTS,5(6),1-12.
MLA Wang, Pan,et al."Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment".SCIENTIFIC REPORTS 5.6(2015):1-12.
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