| Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment | |
Wang, Pan1,2 ; Zhou, Bo1; Yao, Hongxiang3; Zhan, Yafeng4,5; Zhang, Zengqiang1,6; Cui, Yue4,7; Xu, Kaibin4,7; Ma, Jianhua5; Wang, Luning1; An, Ningyu3; Zhang, Xi1; Liu, Yong4,7; Jiang, Tianzi4,7,8; Yong Liu
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| Source Publication | SCIENTIFIC REPORTS
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| 2015-10-06 | |
| Volume | 5Issue:6Pages:1-12 |
| Subtype | Article |
| Abstract | Alzheimer's disease (AD) patients and those with high-risk mild cognitive impairment are increasingly considered to have dysfunction syndromes. Large-scale network studies based on neuroimaging techniques may provide additional insight into AD pathophysiology. The aim of the present study is to evaluate the impaired network functional connectivity with the disease progression. For this purpose, we explored altered functional connectivities based on previously well-defined brain areas that comprise the five key functional systems [the default mode network (DMN), dorsal attention network (DAN), control network (CON), salience network (SAL), sensorimotor network (SMN)] in 35 with AD and 27 with mild cognitive impairment (MCI) subjects, compared with 27 normal cognitive subjects. Based on three levels of analysis, we found that intra-and inter-network connectivity were impaired in AD. Importantly, the interaction between the sensorimotor and attention functions was first attacked at the MCI stage and then extended to the key functional systems in the AD individuals. Lower cognitive ability (lower MMSE scores) was significantly associated with greater reductions in intra-and inter-network connectivity across all patient groups. These profiles indicate that aberrant intra-and inter-network dysfunctions might be potential biomarkers or predictors of AD progression and provide new insight into AD pathophysiology. |
| Keyword | Default-mode Network |
| WOS Headings | Science & Technology |
| DOI | 10.1038/srep14824 |
| WOS Keyword | DEFAULT-MODE NETWORK ; RESTING-STATE FMRI ; ALTERED FUNCTIONAL CONNECTIVITY ; ASSOCIATION WORKGROUPS ; DIAGNOSTIC GUIDELINES ; NATIONAL INSTITUTE ; EXECUTIVE FUNCTION ; AMYLOID BURDEN ; DISCONNECTION SYNDROME ; SALIENCE NETWORK |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000362278500001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/10030 |
| Collection | 脑网络组研究 |
| Corresponding Author | Yong Liu |
| Affiliation | 1.Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Dept Neurol, Beijing 100853, Peoples R China 2.Tianjin Huanhu Hosp, Dept Neurol, Tianjin 300060, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Southern Med Univ, Sch Biomed Engn, Guangzhou 510515, Guangdong, Peoples R China 6.Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Sanya 572014, Peoples R China 7.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 8.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Pan,Zhou, Bo,Yao, Hongxiang,et al. Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment[J]. SCIENTIFIC REPORTS,2015,5(6):1-12. |
| APA | Wang, Pan.,Zhou, Bo.,Yao, Hongxiang.,Zhan, Yafeng.,Zhang, Zengqiang.,...&Yong Liu.(2015).Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment.SCIENTIFIC REPORTS,5(6),1-12. |
| MLA | Wang, Pan,et al."Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment".SCIENTIFIC REPORTS 5.6(2015):1-12. |
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