CASIA OpenIR  > 中国科学院分子影像重点实验室
Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics
Jing, Lijia5; Shi, Jiyun2,3; Fan, Di2; Li, Yaqian4; Liu, Renfa1; Dai, Zhifei1; Wang, Fan2,3; Tian, Jie4
Source PublicationACS APPLIED MATERIALS & INTERFACES
2015-10-07
Volume7Issue:39Pages:22095-22105
SubtypeArticle
AbstractThis Article reported the fabrication of a robust theranostic cerasome encapsulating indocyanine green (ICG) by incorporating 1,2-distearoyl-sn-glycero-3-phosphoethanol-amine-N-[carboxy(polyethylene glycol)2000]-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid monoamide (DSPE-PEG(2000)-DOTA), followed by chelating radioisotope of Lu-177. Its applications in optical and nuclear imaging of tumor uptake and biodistribution, as well as photothermal killing of cancer cells, were investigated. It was found that the obtained cerasome could act efficiently as fluorescence contrast agent as well as nuclear imaging tracer. Encapsulating ICG into cerasome could protect ICG from degradation, aggregation, and fast elimination from body, resulting in remarkable improvement in near-infrared fluorescence imaging, photothermal stability, and in vivo pharmacokinetic profile. Both fluorescence and nuclear imaging showed that such agent could selectively accumulate in tumor site after intravenous injection of the cerasome agent into Lewis lung carcinoma tumor bearing mice, resulting in efficient photothermal ablation of tumor through a one-time NIR laser irradiation at the best time window. The ability to track the uptake of cerasomes on a whole body basis could provide researchers with an excellent tool for developing cerasome-based drug delivery agents, especially the strategy of labeling cerasomes with theranostic radionuclide Lu-177, enabling the ability of the Lu-177-labeled cerasomes for radionuclide cancer therapy and even the combined therapy.
KeywordCerasome Indocyanine Green Multimodal Imaging Photothermal Therapy Nanotheranostics
WOS HeadingsScience & Technology ; Technology
DOI10.1021/acsami.5b07856
WOS KeywordMESOPOROUS SILICA NANOPARTICLES ; TRIGGERED DRUG-RELEASE ; PHOTOTHERMAL THERAPY ; IN-VIVO ; CONTRAST AGENTS ; GOLD NANOCAGES ; FLUORESCENCE ; MICROCAPSULES ; NANOPROBES ; EFFICACY
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000362628900058
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10034
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Peking Univ, Basic Med Sci, Dept Radiat Med, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Biophys, Interdisciplinary Lab, Beijing 100101, Peoples R China
4.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
5.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Jing, Lijia,Shi, Jiyun,Fan, Di,et al. Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(39):22095-22105.
APA Jing, Lijia.,Shi, Jiyun.,Fan, Di.,Li, Yaqian.,Liu, Renfa.,...&Tian, Jie.(2015).Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics.ACS APPLIED MATERIALS & INTERFACES,7(39),22095-22105.
MLA Jing, Lijia,et al."Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics".ACS APPLIED MATERIALS & INTERFACES 7.39(2015):22095-22105.
Files in This Item: Download All
File Name/Size DocType Version Access License
am5b07856_si_001.pdf(563KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Jing, Lijia]'s Articles
[Shi, Jiyun]'s Articles
[Fan, Di]'s Articles
Baidu academic
Similar articles in Baidu academic
[Jing, Lijia]'s Articles
[Shi, Jiyun]'s Articles
[Fan, Di]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Jing, Lijia]'s Articles
[Shi, Jiyun]'s Articles
[Fan, Di]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: am5b07856_si_001.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.