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Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method
Liu, Haixiao1,2; Yang, Xin1,2; Song, Tianming1; Bao, Chengpeng1; Shi, Liangliang1,2; Hu, Zhenhua1,2; Wang, Kun1,2; Tian, Jie1,2
2015-08-01
发表期刊JOURNAL OF BIOMEDICAL OPTICS
卷号20期号:8页码:086007
文章类型Article
摘要Cerenkov luminescence tomography (CLT) is a promising tool that enables three-dimensional non-invasive in vivo detection of radiopharmaceuticals. Conventionally, multispectral information and diffusion theory were introduced to achieve whole-body tomographic reconstruction. However, the diffusion theory inevitably causes systematic error in blue bands of the electromagnetic spectrum due to high-tissue absorption, and CL has a blue-weighted broad spectrum. Therefore, it is challenging to improve the accuracy of CLT. The performance of the n-order simplified spherical harmonics approximation (SPn) in different spectra is evaluated, and a multispectral hybrid CLT based on the combination of different SPn models is proposed to handle the Cerenkov photon transport problem in complex media. The in vivo xenograft experiment shows that this approach can effectively improve the quality and accuracy of the reconstructed light source. We believe that the new reconstruction method will advance the development of CLT for more in vivo imaging applications. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
关键词Cerenkov Luminescence Tomography Spherical Harmonics Approximation Multispectral Diffusion Theory
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1117/1.JBO.20.8.086007
关键词[WOS]MOUSE MODEL ; LIGHT ; RADIOTRACERS ; PET
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000362516700018
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10040
专题中国科学院分子影像重点实验室
通讯作者Hu, Zhenhua; Wang, Kun; Tian, Jie
作者单位1.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
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Liu, Haixiao,Yang, Xin,Song, Tianming,et al. Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method[J]. JOURNAL OF BIOMEDICAL OPTICS,2015,20(8):086007.
APA Liu, Haixiao.,Yang, Xin.,Song, Tianming.,Bao, Chengpeng.,Shi, Liangliang.,...&Tian, Jie.(2015).Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method.JOURNAL OF BIOMEDICAL OPTICS,20(8),086007.
MLA Liu, Haixiao,et al."Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method".JOURNAL OF BIOMEDICAL OPTICS 20.8(2015):086007.
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