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Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method
Liu, Haixiao1,2; Yang, Xin1,2; Song, Tianming1; Bao, Chengpeng1; Shi, Liangliang1,2; Hu, Zhenhua1,2; Wang, Kun1,2; Tian, Jie1,2
Source PublicationJOURNAL OF BIOMEDICAL OPTICS
2015-08-01
Volume20Issue:8Pages:086007
SubtypeArticle
AbstractCerenkov luminescence tomography (CLT) is a promising tool that enables three-dimensional non-invasive in vivo detection of radiopharmaceuticals. Conventionally, multispectral information and diffusion theory were introduced to achieve whole-body tomographic reconstruction. However, the diffusion theory inevitably causes systematic error in blue bands of the electromagnetic spectrum due to high-tissue absorption, and CL has a blue-weighted broad spectrum. Therefore, it is challenging to improve the accuracy of CLT. The performance of the n-order simplified spherical harmonics approximation (SPn) in different spectra is evaluated, and a multispectral hybrid CLT based on the combination of different SPn models is proposed to handle the Cerenkov photon transport problem in complex media. The in vivo xenograft experiment shows that this approach can effectively improve the quality and accuracy of the reconstructed light source. We believe that the new reconstruction method will advance the development of CLT for more in vivo imaging applications. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
KeywordCerenkov Luminescence Tomography Spherical Harmonics Approximation Multispectral Diffusion Theory
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1117/1.JBO.20.8.086007
WOS KeywordMOUSE MODEL ; LIGHT ; RADIOTRACERS ; PET
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000362516700018
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10040
Collection中国科学院分子影像重点实验室
Corresponding AuthorHu, Zhenhua; Wang, Kun; Tian, Jie
Affiliation1.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Liu, Haixiao,Yang, Xin,Song, Tianming,et al. Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method[J]. JOURNAL OF BIOMEDICAL OPTICS,2015,20(8):086007.
APA Liu, Haixiao.,Yang, Xin.,Song, Tianming.,Bao, Chengpeng.,Shi, Liangliang.,...&Tian, Jie.(2015).Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method.JOURNAL OF BIOMEDICAL OPTICS,20(8),086007.
MLA Liu, Haixiao,et al."Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method".JOURNAL OF BIOMEDICAL OPTICS 20.8(2015):086007.
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