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A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics
Jiang, Qiao1; Shi, Yuefeng2; Zhang, Qian3; Li, Na1; Zhan, Pengfei1; Song, Linlin1; Dai, Luru1; Tian, Jie3; Du, Yang3; Cheng, Zhen4; Ding, Baoquan1
2015-10-14
发表期刊SMALL
卷号11期号:38页码:5134-5141
文章类型Article
摘要A self-assembled DNA origami (DO)-gold nanorod (GNR) complex, which is a dual-functional nanotheranostics constructed by decorating GNRs onto the surface of DNA origami, is demonstrated. After 24 h incubation of two structured DO-GNR complexes with human MCF7 breast cancer cells, significant enhancement of cell uptake is achieved compared to bare GNRs by two-photon luminescence imaging. Particularly, the triangle shaped DO-GNR complex exhibits optimal cellular accumulation. Compared to GNRs, improved photothermolysis against tumor cells is accomplished for the triangle DO-GNR complex by two-photon laser or NIR laser irradiation. Moreover, the DO-GNR complex exhibits enhanced antitumor efficacy compared with bare GNRs in nude mice bearing breast tumor xenografts. The results demonstrate that the DO-GNR complex can achieve optimal two-photon cell imaging and photothermal effect, suggesting a promising candidate for cancer diagnosis and therapy both in vitro and in vivo.
关键词None
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1002/smll.201501266
关键词[WOS]PHOTOTHERMAL THERAPY PPTT ; DRUG-DELIVERY ; NANOPARTICLES ; NANOSTRUCTURES ; NANOTECHNOLOGY ; CARCINOMA ; PLATFORM ; SHAPES ; CELLS ; MICE
收录类别SCI
语种英语
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000362819700017
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10334
专题中国科学院分子影像重点实验室
作者单位1.Natl Ctr NanoSci & Technol, CAS Key Lab Nanosyst & Hierarchial Fabricat, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
4.Stanford Univ, Dept Radiol, Lucas Ctr, Stanford, CA 94305 USA
推荐引用方式
GB/T 7714
Jiang, Qiao,Shi, Yuefeng,Zhang, Qian,et al. A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics[J]. SMALL,2015,11(38):5134-5141.
APA Jiang, Qiao.,Shi, Yuefeng.,Zhang, Qian.,Li, Na.,Zhan, Pengfei.,...&Ding, Baoquan.(2015).A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics.SMALL,11(38),5134-5141.
MLA Jiang, Qiao,et al."A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics".SMALL 11.38(2015):5134-5141.
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