CASIA OpenIR  > 中国科学院分子影像重点实验室
A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics
Jiang, Qiao1; Shi, Yuefeng2; Zhang, Qian3; Li, Na1; Zhan, Pengfei1; Song, Linlin1; Dai, Luru1; Tian, Jie3; Du, Yang3; Cheng, Zhen4; Ding, Baoquan1
Source PublicationSMALL
2015-10-14
Volume11Issue:38Pages:5134-5141
SubtypeArticle
AbstractA self-assembled DNA origami (DO)-gold nanorod (GNR) complex, which is a dual-functional nanotheranostics constructed by decorating GNRs onto the surface of DNA origami, is demonstrated. After 24 h incubation of two structured DO-GNR complexes with human MCF7 breast cancer cells, significant enhancement of cell uptake is achieved compared to bare GNRs by two-photon luminescence imaging. Particularly, the triangle shaped DO-GNR complex exhibits optimal cellular accumulation. Compared to GNRs, improved photothermolysis against tumor cells is accomplished for the triangle DO-GNR complex by two-photon laser or NIR laser irradiation. Moreover, the DO-GNR complex exhibits enhanced antitumor efficacy compared with bare GNRs in nude mice bearing breast tumor xenografts. The results demonstrate that the DO-GNR complex can achieve optimal two-photon cell imaging and photothermal effect, suggesting a promising candidate for cancer diagnosis and therapy both in vitro and in vivo.
KeywordNone
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1002/smll.201501266
WOS KeywordPHOTOTHERMAL THERAPY PPTT ; DRUG-DELIVERY ; NANOPARTICLES ; NANOSTRUCTURES ; NANOTECHNOLOGY ; CARCINOMA ; PLATFORM ; SHAPES ; CELLS ; MICE
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000362819700017
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10334
Collection中国科学院分子影像重点实验室
Affiliation1.Natl Ctr NanoSci & Technol, CAS Key Lab Nanosyst & Hierarchial Fabricat, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
4.Stanford Univ, Dept Radiol, Lucas Ctr, Stanford, CA 94305 USA
Recommended Citation
GB/T 7714
Jiang, Qiao,Shi, Yuefeng,Zhang, Qian,et al. A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics[J]. SMALL,2015,11(38):5134-5141.
APA Jiang, Qiao.,Shi, Yuefeng.,Zhang, Qian.,Li, Na.,Zhan, Pengfei.,...&Ding, Baoquan.(2015).A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics.SMALL,11(38),5134-5141.
MLA Jiang, Qiao,et al."A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics".SMALL 11.38(2015):5134-5141.
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