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Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind
Jiang, Aili1,2; Tian, Jing1,2; Li, Rui1,2; Liu, Yong3; Jiang, Tianzi3; Qin, Wen1,2; Yu, Chunshui1,2
Source PublicationNEURAL PLASTICITY
2015
SubtypeArticle
AbstractVisual deprivation can induce alterations of regional spontaneous brain activity (RSBA). However, the effects of onset age of blindness on the RSBA and the association between the alterations of RSBA and brain structure are still unclear in the blind. In this study, we performed resting-state functional and structural magnetic resonance imaging on 50 sighted controls and 91 blind subjects (20 congenitally blind, 27 early blind, and 44 late blind individuals). Compared with the sighted control, we identified increased RSBA in the blind in primary and high-level visual areas and decreased RSBA in brain regions which are ascribed to sensorimotor and salience networks. In contrast, blind subjects exhibited significantly decreased gray matter volume (GMV) in the visual areas, while they exhibited significantly increased GMV in the sensorimotor areas. Moreover, the onset age of blindness was negatively correlated with the GMV of visual areas in blind subjects, whereas it exerted complex influences on the RSBA. Finally, significant negative correlations were shown between RSBA and GMV values. Our results demonstrated system-dependent, inverse alterations in RSBA and GMV after visual deprivation. Furthermore, the onset age of blindness has different effects on the reorganizations in RSBA and GMV.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1155/2015/141950
WOS KeywordVISUAL-CORTEX ; OCCIPITAL CORTEX ; CONGENITAL BLINDNESS ; SENSITIVE PERIOD ; NEURAL ACTIVITY ; WHITE-MATTER ; CONNECTIVITY ; HUMANS ; FMRI ; INDIVIDUALS
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81401394 ; National Basic Research Program of China (973 program)(2011CB707800) ; 91332113 ; 81271551 ; 81270020 ; 81271564 ; 90920015 ; 81171423)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000364138400001
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10502
Collection脑网络组研究中心
Affiliation1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Aili,Tian, Jing,Li, Rui,et al. Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind[J]. NEURAL PLASTICITY,2015.
APA Jiang, Aili.,Tian, Jing.,Li, Rui.,Liu, Yong.,Jiang, Tianzi.,...&Yu, Chunshui.(2015).Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind.NEURAL PLASTICITY.
MLA Jiang, Aili,et al."Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind".NEURAL PLASTICITY (2015).
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