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Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind
Jiang, Aili1,2; Tian, Jing1,2; Li, Rui1,2; Liu, Yong3; Jiang, Tianzi3; Qin, Wen1,2; Yu, Chunshui1,2
2015
发表期刊NEURAL PLASTICITY
文章类型Article
摘要Visual deprivation can induce alterations of regional spontaneous brain activity (RSBA). However, the effects of onset age of blindness on the RSBA and the association between the alterations of RSBA and brain structure are still unclear in the blind. In this study, we performed resting-state functional and structural magnetic resonance imaging on 50 sighted controls and 91 blind subjects (20 congenitally blind, 27 early blind, and 44 late blind individuals). Compared with the sighted control, we identified increased RSBA in the blind in primary and high-level visual areas and decreased RSBA in brain regions which are ascribed to sensorimotor and salience networks. In contrast, blind subjects exhibited significantly decreased gray matter volume (GMV) in the visual areas, while they exhibited significantly increased GMV in the sensorimotor areas. Moreover, the onset age of blindness was negatively correlated with the GMV of visual areas in blind subjects, whereas it exerted complex influences on the RSBA. Finally, significant negative correlations were shown between RSBA and GMV values. Our results demonstrated system-dependent, inverse alterations in RSBA and GMV after visual deprivation. Furthermore, the onset age of blindness has different effects on the reorganizations in RSBA and GMV.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1155/2015/141950
关键词[WOS]VISUAL-CORTEX ; OCCIPITAL CORTEX ; CONGENITAL BLINDNESS ; SENSITIVE PERIOD ; NEURAL ACTIVITY ; WHITE-MATTER ; CONNECTIVITY ; HUMANS ; FMRI ; INDIVIDUALS
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81401394 ; National Basic Research Program of China (973 program)(2011CB707800) ; 91332113 ; 81271551 ; 81270020 ; 81271564 ; 90920015 ; 81171423)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000364138400001
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10502
专题脑网络组研究中心
作者单位1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
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Jiang, Aili,Tian, Jing,Li, Rui,et al. Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind[J]. NEURAL PLASTICITY,2015.
APA Jiang, Aili.,Tian, Jing.,Li, Rui.,Liu, Yong.,Jiang, Tianzi.,...&Yu, Chunshui.(2015).Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind.NEURAL PLASTICITY.
MLA Jiang, Aili,et al."Alterations of Regional Spontaneous Brain Activity and Gray Matter Volume in the Blind".NEURAL PLASTICITY (2015).
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