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Cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia
Zeng, F.1; Lan, L.1; Tang, Y.1; Liu, M.2; Liu, X.1; Song, W.3,4; Li, Y.1; Qin, W.5; Sun, J.5; Yu, S.1; Gao, X.6; Tian, J.5,7; Liang, F.1; Liang, Fanrong
2015-04-01
发表期刊NEUROGASTROENTEROLOGY AND MOTILITY
卷号27期号:4页码:559-568
文章类型Article
摘要Background To investigate the similarities and differences in cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia (FD). Methods Twenty right-handed FD patients were enrolled and randomized divided into two groups. Each patient received 20 sessions' electroacupuncture treatment. The acupoints used in Group A were four acupoints on the Stomach Meridian, and the acupoints used in Group B were four acupoints on the Gallbladder Meridian. PET-CT scans were performed before and after acupuncture treatment to record the changes of cerebral glycometabolism. Key Results After treatment, the dyspepsia symptoms and the quality of life (QOL) of the patients in each group were significantly improved (p < 0.05) and there was insignificant difference in efficacy between the two groups (p > 0.05). In Group A, deactivation in brainstem, bilateral anterior cingulate cortex (ACC) and cerebellum, left superior medial frontal gyrus, orbital frontal cortex (OFC), and thalamus, etc., and activation in bilateral middle cingulate cortex (MCC), precuneus and lingual gyrus, etc. were observed. In Group B, deactivation in brainstem, bilateral thalamus, putamen, ACC, postterior cingulate cortex, hippocampus and cerebellum, etc., and activation in bilateral MCC, precuneus, left OFC, etc. were observed (p < 0.05, Family-wise error corrected). Conclusions & Inferences Different acupoints have similar clinical efficacy but relatively different cerebral responses. The influence on the sensory transduction regions (brainstem and thalamus) and visceral modulation regions might be the common mechanism of different acupoints treating for FD, and the modulation on some emotion/cognition-related areas (e.g., prefrontal cortex) is the potential difference between the different acupoints.
关键词Acupoint Specificity Cerebral Activity Functional Dyspepsia
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1111/nmo.12532
关键词[WOS]QUALITY-OF-LIFE ; ACUPUNCTURE TREATMENT ; PET-CT ; CONNECTIVITY ANALYSIS ; GASTRIC-MOTILITY ; BRAIN ACTIVITY ; SPECIFICITY ; DISORDERS ; ANXIETY ; DEPRESSION
收录类别SCI
语种英语
项目资助者National Basic Research Program of China (973 Program)(2012CB518501) ; Youth Foundation of National Natural Science Foundation of China(81001504) ; New Century Outstanding Talents Support Program of Education Ministry of China ; Youth Foundation of Sichuan Province(2012JQ0052)
WOS研究方向Gastroenterology & Hepatology ; Neurosciences & Neurology
WOS类目Gastroenterology & Hepatology ; Clinical Neurology ; Neurosciences
WOS记录号WOS:000364740900012
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10504
专题中国科学院分子影像重点实验室
通讯作者Liang, Fanrong
作者单位1.Chengdu Univ Tradit Chinese Med, Acupunture & Tuina Sch, Teaching Hosp 3, Chengdu 610075, Sichuan, Peoples R China
2.Hunan Univ Tradit Chinese Med, Acupunture & Tuina Sch, Changsha, Hunan, Peoples R China
3.Sichuan Acad Med Sci, PET CT Ctr, Chengdu, Sichuan, Peoples R China
4.Sichuan Prov Peoples Hosp, Chengdu, Sichuan, Peoples R China
5.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian, Shaanxi, Peoples R China
6.Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
7.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
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Zeng, F.,Lan, L.,Tang, Y.,et al. Cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia[J]. NEUROGASTROENTEROLOGY AND MOTILITY,2015,27(4):559-568.
APA Zeng, F..,Lan, L..,Tang, Y..,Liu, M..,Liu, X..,...&Liang, Fanrong.(2015).Cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia.NEUROGASTROENTEROLOGY AND MOTILITY,27(4),559-568.
MLA Zeng, F.,et al."Cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia".NEUROGASTROENTEROLOGY AND MOTILITY 27.4(2015):559-568.
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