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Cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia
Zeng, F.1; Lan, L.1; Tang, Y.1; Liu, M.2; Liu, X.1; Song, W.3,4; Li, Y.1; Qin, W.5; Sun, J.5; Yu, S.1; Gao, X.6; Tian, J.5,7; Liang, F.1; Liang, Fanrong
Source PublicationNEUROGASTROENTEROLOGY AND MOTILITY
2015-04-01
Volume27Issue:4Pages:559-568
SubtypeArticle
AbstractBackground To investigate the similarities and differences in cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia (FD). Methods Twenty right-handed FD patients were enrolled and randomized divided into two groups. Each patient received 20 sessions' electroacupuncture treatment. The acupoints used in Group A were four acupoints on the Stomach Meridian, and the acupoints used in Group B were four acupoints on the Gallbladder Meridian. PET-CT scans were performed before and after acupuncture treatment to record the changes of cerebral glycometabolism. Key Results After treatment, the dyspepsia symptoms and the quality of life (QOL) of the patients in each group were significantly improved (p < 0.05) and there was insignificant difference in efficacy between the two groups (p > 0.05). In Group A, deactivation in brainstem, bilateral anterior cingulate cortex (ACC) and cerebellum, left superior medial frontal gyrus, orbital frontal cortex (OFC), and thalamus, etc., and activation in bilateral middle cingulate cortex (MCC), precuneus and lingual gyrus, etc. were observed. In Group B, deactivation in brainstem, bilateral thalamus, putamen, ACC, postterior cingulate cortex, hippocampus and cerebellum, etc., and activation in bilateral MCC, precuneus, left OFC, etc. were observed (p < 0.05, Family-wise error corrected). Conclusions & Inferences Different acupoints have similar clinical efficacy but relatively different cerebral responses. The influence on the sensory transduction regions (brainstem and thalamus) and visceral modulation regions might be the common mechanism of different acupoints treating for FD, and the modulation on some emotion/cognition-related areas (e.g., prefrontal cortex) is the potential difference between the different acupoints.
KeywordAcupoint Specificity Cerebral Activity Functional Dyspepsia
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1111/nmo.12532
WOS KeywordQUALITY-OF-LIFE ; ACUPUNCTURE TREATMENT ; PET-CT ; CONNECTIVITY ANALYSIS ; GASTRIC-MOTILITY ; BRAIN ACTIVITY ; SPECIFICITY ; DISORDERS ; ANXIETY ; DEPRESSION
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of China (973 Program)(2012CB518501) ; Youth Foundation of National Natural Science Foundation of China(81001504) ; New Century Outstanding Talents Support Program of Education Ministry of China ; Youth Foundation of Sichuan Province(2012JQ0052)
WOS Research AreaGastroenterology & Hepatology ; Neurosciences & Neurology
WOS SubjectGastroenterology & Hepatology ; Clinical Neurology ; Neurosciences
WOS IDWOS:000364740900012
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10504
Collection中国科学院分子影像重点实验室
Corresponding AuthorLiang, Fanrong
Affiliation1.Chengdu Univ Tradit Chinese Med, Acupunture & Tuina Sch, Teaching Hosp 3, Chengdu 610075, Sichuan, Peoples R China
2.Hunan Univ Tradit Chinese Med, Acupunture & Tuina Sch, Changsha, Hunan, Peoples R China
3.Sichuan Acad Med Sci, PET CT Ctr, Chengdu, Sichuan, Peoples R China
4.Sichuan Prov Peoples Hosp, Chengdu, Sichuan, Peoples R China
5.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian, Shaanxi, Peoples R China
6.Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
7.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zeng, F.,Lan, L.,Tang, Y.,et al. Cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia[J]. NEUROGASTROENTEROLOGY AND MOTILITY,2015,27(4):559-568.
APA Zeng, F..,Lan, L..,Tang, Y..,Liu, M..,Liu, X..,...&Liang, Fanrong.(2015).Cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia.NEUROGASTROENTEROLOGY AND MOTILITY,27(4),559-568.
MLA Zeng, F.,et al."Cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia".NEUROGASTROENTEROLOGY AND MOTILITY 27.4(2015):559-568.
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