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The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation
Jiang, Guangyao1; Yin, Xuntao1,2; Li, Chuanming1; Li, Lei3; Zhao, Lu2; Evans, Alan C.2; Jiang, Tianzi4; Wu, Jixiang3; Wang, Jian1
Source PublicationNEURAL PLASTICITY
2015
SubtypeArticle
AbstractAccumulating evidence has indicated that amputation induces functional reorganization in the sensory and motor cortices. However, the extent of structural changes after lower limb amputation in patients without phantom pain remains uncertain. We studied 17 adult patients with right lower limb amputation and 18 healthy control subjects using T1-weighted magnetic resonance imaging and diffusion tensor imaging. Cortical thickness and fractional anisotropy (FA) of white matter (WM) were investigated. In amputees, a thinning trend was seen in the left premotor cortex (PMC). Smaller clusters were also noted in the visual-to-motor regions. In addition, the amputees also exhibited a decreased FA in the right superior corona radiata and WM regions underlying the right temporal lobe and left PMC. Fiber tractography from these WM regions showed microstructural changes in the commissural fibers connecting the bilateral premotor cortices, compatible with the hypothesis that amputation can lead to a change in interhemispheric interactions. Finally, the lower limb amputees also displayed significant FA reduction in the right inferior frontooccipital fasciculus, which is negatively correlated with the time since amputation. In conclusion, our findings indicate that the amputation of lower limb could induce changes in the cortical representation of the missing limb and the underlying WM connections.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1155/2015/823185
WOS KeywordCORTICAL REORGANIZATION ; PREMOTOR CORTEX ; PARIETAL-CORTEX ; MOTOR CORTEX ; PAIN ; ATTENTION ; SELECTION ; AMPUTEES ; INJURY ; IMAGES
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China for Young Scholars(81301205) ; Open Project Program of the National Laboratory of Pattern Recognition (NLPR) in China(201306283)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000364719700001
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Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10505
Collection脑网络组研究中心
Affiliation1.Third Mil Med Univ, Dept Radiol, Southwest Hosp, Chongqing 400038, Peoples R China
2.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada
3.Third Mil Med Univ, Dept Rehabil, Southwest Hosp, Chongqing 400038, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Guangyao,Yin, Xuntao,Li, Chuanming,et al. The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation[J]. NEURAL PLASTICITY,2015.
APA Jiang, Guangyao.,Yin, Xuntao.,Li, Chuanming.,Li, Lei.,Zhao, Lu.,...&Wang, Jian.(2015).The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation.NEURAL PLASTICITY.
MLA Jiang, Guangyao,et al."The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation".NEURAL PLASTICITY (2015).
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