CASIA OpenIR  > 脑网络组研究中心
The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation
Jiang, Guangyao1; Yin, Xuntao1,2; Li, Chuanming1; Li, Lei3; Zhao, Lu2; Evans, Alan C.2; Jiang, Tianzi4; Wu, Jixiang3; Wang, Jian1
2015
发表期刊NEURAL PLASTICITY
文章类型Article
摘要Accumulating evidence has indicated that amputation induces functional reorganization in the sensory and motor cortices. However, the extent of structural changes after lower limb amputation in patients without phantom pain remains uncertain. We studied 17 adult patients with right lower limb amputation and 18 healthy control subjects using T1-weighted magnetic resonance imaging and diffusion tensor imaging. Cortical thickness and fractional anisotropy (FA) of white matter (WM) were investigated. In amputees, a thinning trend was seen in the left premotor cortex (PMC). Smaller clusters were also noted in the visual-to-motor regions. In addition, the amputees also exhibited a decreased FA in the right superior corona radiata and WM regions underlying the right temporal lobe and left PMC. Fiber tractography from these WM regions showed microstructural changes in the commissural fibers connecting the bilateral premotor cortices, compatible with the hypothesis that amputation can lead to a change in interhemispheric interactions. Finally, the lower limb amputees also displayed significant FA reduction in the right inferior frontooccipital fasciculus, which is negatively correlated with the time since amputation. In conclusion, our findings indicate that the amputation of lower limb could induce changes in the cortical representation of the missing limb and the underlying WM connections.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1155/2015/823185
关键词[WOS]CORTICAL REORGANIZATION ; PREMOTOR CORTEX ; PARIETAL-CORTEX ; MOTOR CORTEX ; PAIN ; ATTENTION ; SELECTION ; AMPUTEES ; INJURY ; IMAGES
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China for Young Scholars(81301205) ; Open Project Program of the National Laboratory of Pattern Recognition (NLPR) in China(201306283)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000364719700001
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10505
专题脑网络组研究中心
作者单位1.Third Mil Med Univ, Dept Radiol, Southwest Hosp, Chongqing 400038, Peoples R China
2.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada
3.Third Mil Med Univ, Dept Rehabil, Southwest Hosp, Chongqing 400038, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Guangyao,Yin, Xuntao,Li, Chuanming,et al. The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation[J]. NEURAL PLASTICITY,2015.
APA Jiang, Guangyao.,Yin, Xuntao.,Li, Chuanming.,Li, Lei.,Zhao, Lu.,...&Wang, Jian.(2015).The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation.NEURAL PLASTICITY.
MLA Jiang, Guangyao,et al."The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation".NEURAL PLASTICITY (2015).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jiang, Guangyao]的文章
[Yin, Xuntao]的文章
[Li, Chuanming]的文章
百度学术
百度学术中相似的文章
[Jiang, Guangyao]的文章
[Yin, Xuntao]的文章
[Li, Chuanming]的文章
必应学术
必应学术中相似的文章
[Jiang, Guangyao]的文章
[Yin, Xuntao]的文章
[Li, Chuanming]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。