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RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory
Li, Jin1,2; Liu, Bing1,2; Chen, Chuansheng3; Cui, Yue1,2; Shang, Liqing4; Zhang, Yun4; Wang, Chao4; Zhang, Xiaolong1,2; He, Qinghua5; Zhang, Wen4; Bi, Wenwei4; Jiang, Tianzi1,2,4,6
Source PublicationHUMAN BRAIN MAPPING
2015-11-01
Volume36Issue:11Pages:4372-4382
SubtypeArticle
AbstractCalbindin-containing -aminobutyric acid (GABA)ergic interneurons in the prefrontal cortex (PFC) have been found to play an important role in working memory (WM) and their malfunctions have been linked to psychiatric disorders. A recent genome-wide association and expression-SNP study indicated that the RAB2A gene was associated with the density of prefrontal calbindin-positive neurons, suggesting this gene may have a broader influence on prefrontal structure and function. Using multimodal MRI and behavioral tasks, the current study investigated the effect of RAB2A on prefrontal morphology, resting-state functional connectivity, and WM performance in a large sample of healthy Han Chinese subjects. Results showed that the RAB2A AGCAAA haplotype was associated with improved WM accuracy, increased cortical thickness in the left inferior frontal gyrus, and decreased functional connectivity between the left inferior frontal gyrus and the left dorsolateral PFC. Our findings provide consistent evidence supporting the effect of RAB2A on the structure and function of the PFC and related cognitive functions. These results should provide new insights into the neural mechanisms underlying the GABAergic genes' role in WM as well as its dysfunction. Hum Brain Mapp 36:4372-4382, 2015. (c) 2015 Wiley Periodicals, Inc.
KeywordRas-related Protein Rab-2a (Rab2a) Cortical Thickness Functional Connectivity Working Memory
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1002/hbm.22924
WOS KeywordCORE VESICLE MATURATION ; CALCIUM-BINDING PROTEINS ; SURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; CAENORHABDITIS-ELEGANS ; GABAERGIC NEURONS ; HUMAN BRAIN ; CORTICAL THICKNESS ; SCHIZOPHRENIA ; NETWORKS
Indexed BySCI
Language英语
Funding OrganizationNational Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(81000582 ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning(CNLYB1313) ; Key Laboratory for NeuroInformation of Ministry of Education ; 31300934 ; 91132301 ; 91232718)
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000364219500011
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10506
Collection脑网络组研究中心
Affiliation1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA USA
4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China
5.Southwest Univ, Fac Psychol, Chongqing 400715, Peoples R China
6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
Recommended Citation
GB/T 7714
Li, Jin,Liu, Bing,Chen, Chuansheng,et al. RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory[J]. HUMAN BRAIN MAPPING,2015,36(11):4372-4382.
APA Li, Jin.,Liu, Bing.,Chen, Chuansheng.,Cui, Yue.,Shang, Liqing.,...&Jiang, Tianzi.(2015).RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory.HUMAN BRAIN MAPPING,36(11),4372-4382.
MLA Li, Jin,et al."RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory".HUMAN BRAIN MAPPING 36.11(2015):4372-4382.
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