CASIA OpenIR  > 中国科学院分子影像重点实验室
Disrupted inter-hemispheric functional and structural coupling in Internet addiction adolescents
Bi, Yanzhi1,2; Yuan, Kai1,2; Feng, Dan1,2; Xing, Lihong1,2; Li, Yangding1,2; Wang, Hongmei3; Yu, Dahua4; Xue, Ting5; Jin, Chenwang3; Qin, Wei1,2; Tian, Jie1,2,6
AbstractRapid progress had been made towards the effect of Internet addiction (IA) on the adolescents brain, relatively little is known about the alterations in inter-hemispheric resting state functional connectivity (RSFC) changes. In the current study, voxel-mirrored homotopic connectivity (VMHC) was used to examine inter-hemispheric RSFC in IA adolescents (n=21) and controls (n=21). The integrity of the fibers connecting the regions, which showed aberrant inter-hemispheric functional connectivity, was assessed by fiber tractography analysis. In addition, the coupling of inter-hemispheric functional and structural connectivity was investigated. Relative to controls, IA adolescents showed decreased VMHC of dorsolateral prefrontal cortex (DLPFC) and reduced fractional anisotropy (FA) values in the genu of corpus callosum (CC). The decreased VMHC of DLPFC was significantly negative correlated with the duration of IA. Moreover, the VMHC of DLPFC showed significant correlations with the FA of CC in healthy controls, which was disrupted in IA. Our findings provided more scientific evidence for the involvement of DLPFC in IA. It is hoped that multimodal imaging methods can provide deeper insights into the IA effects on the brain. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
KeywordInternet Addiction Voxel-mirrored Homotopic Connectivity Dorsolateral Prefrontal Cortex Corpus Callosum Fractional Anisotropy
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationProject for the National Key Basic Research and Development Program (973)(2014CB543203 ; National Natural Science Foundation of China(81571751 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities(JB151204 ; Natural Science Foundation of Inner Mongolia(2014BS0610) ; Inner Mongolia University of Science and Technology(2015QNGG03 ; China Postdoctoral Science Foundation(2014M552416) ; 2011CB707700 ; 81571753 ; JB121405) ; 2014QDL002) ; 2012CB518501) ; 61502376 ; 81401478 ; 81401488 ; 81271644 ; 81271546 ; 81271549 ; 81470816 ; 81471737 ; 81301281)
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Neuroimaging ; Psychiatry
WOS IDWOS:000365053600001
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Document Type期刊论文
Corresponding AuthorJin, Chenwang
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Wuhan, Peoples R China
3.Xi An Jiao Tong Univ, Dept Med Imaging, Affiliated Hosp 1, Xian 710049, Shaanxi, Peoples R China
4.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Informat Proc Lab, Baotou, Inner Mongolia, Peoples R China
5.Inner Mongolia Univ Sci & Technol, Sch Math Phys & Biol Engn, Baotou, Inner Mongolia, Peoples R China
6.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Bi, Yanzhi,Yuan, Kai,Feng, Dan,et al. Disrupted inter-hemispheric functional and structural coupling in Internet addiction adolescents[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,234(2):157-163.
APA Bi, Yanzhi.,Yuan, Kai.,Feng, Dan.,Xing, Lihong.,Li, Yangding.,...&Tian, Jie.(2015).Disrupted inter-hemispheric functional and structural coupling in Internet addiction adolescents.PSYCHIATRY RESEARCH-NEUROIMAGING,234(2),157-163.
MLA Bi, Yanzhi,et al."Disrupted inter-hemispheric functional and structural coupling in Internet addiction adolescents".PSYCHIATRY RESEARCH-NEUROIMAGING 234.2(2015):157-163.
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