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Functional Connectivity Hubs Could Serve as a Potential Biomarker in Alzheimer's Disease: A Reproducible Study
Sui, Xiuchao1,2; Zhu, Maohu1,2; Cui, Yue1,2; Yu, Chunshui3,4; Sui, Jing1,2,5; Zhang, Xinqing6; Liu, Jieqiong6; Duan, Yunyun4; Zhang, Zengqiang7,8; Wang, Luning7; Zhang, Xi7; Jiang, Tianzi1,2,9,10
2015
发表期刊CURRENT ALZHEIMER RESEARCH
卷号12期号:10页码:974-983
文章类型Article
摘要Cortical hubs that link functionally specialized neural systems are crucial for cognition. Evidence suggests that the location and organization of hubs are related to Alzheimer's disease (AD). However, two issues remain unclear: (i) where and how hubs change in AD, and (ii) whether hubs could be a potential pre-diagnosis biomarker for mild cognitive impairment (MCI) - a prodromal phase of AD. Accordingly, we examined the functional connectivity density (FCD) in two cohorts of resting-state functional magnetic resonance imaging (fMRI) scans (26 AD, 27 controls; 33 AD, 21 controls) and revealed consistently vulnerable FCD hub regions in AD compared with controls: within the default mode network, short-range FCD decreases in the posterior cingulate cortex and increases in the medial prefrontal cortex; within the frontal lobe, long-range FCD increases in the medial prefrontal cortex, superior frontal gyrus and middle frontal gyrus. Furthermore, FCD correlates with cognitive score and could distinguish MCI from controls with high accuracy (71.08% in dataset 1, 81% in dataset 2). By reflecting a robust and reproducible global shift in brain functions, FCD provides an fMRI biomarker for the underlying mechanism in AD.
关键词Alzheimer's Disease Biomarker Classification Functional Connectivity Density Mild Cognitive Impairment Resting State Functional Mri
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.2174/1567205012666150710111615
关键词[WOS]MILD COGNITIVE IMPAIRMENT ; POSITRON-EMISSION-TOMOGRAPHY ; DEFAULT-MODE NETWORK ; RESTING-STATE FMRI ; BRAIN NETWORKS ; ASSOCIATION WORKGROUPS ; DIAGNOSTIC GUIDELINES ; NATIONAL INSTITUTE ; CORTICAL NETWORKS ; CEREBRAL-CORTEX
收录类别SCI
语种英语
项目资助者National Key Basic Research, Development Program of China (973 program)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB020-30300) ; Natural Science Foundation of China(91132301 ; One Hundred Talents Plan of Chinese Academy of Science ; 61305143 ; 60831004)
WOS研究方向Neurosciences & Neurology
WOS类目Clinical Neurology ; Neurosciences
WOS记录号WOS:000366135300007
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10528
专题脑网络组研究中心
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
4.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China
5.Mind Res Network, Albuquerque, NM 87106 USA
6.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China
7.Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Dept Neurol, Beijing 100853, Peoples R China
8.Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Sanya 572014, Peoples R China
9.Univ Elect Sci & Technol China, Minist Educ, Sch Life Sci & Technol, Key Lab Neuro Informat, Chengdu 610054, Peoples R China
10.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
推荐引用方式
GB/T 7714
Sui, Xiuchao,Zhu, Maohu,Cui, Yue,et al. Functional Connectivity Hubs Could Serve as a Potential Biomarker in Alzheimer's Disease: A Reproducible Study[J]. CURRENT ALZHEIMER RESEARCH,2015,12(10):974-983.
APA Sui, Xiuchao.,Zhu, Maohu.,Cui, Yue.,Yu, Chunshui.,Sui, Jing.,...&Jiang, Tianzi.(2015).Functional Connectivity Hubs Could Serve as a Potential Biomarker in Alzheimer's Disease: A Reproducible Study.CURRENT ALZHEIMER RESEARCH,12(10),974-983.
MLA Sui, Xiuchao,et al."Functional Connectivity Hubs Could Serve as a Potential Biomarker in Alzheimer's Disease: A Reproducible Study".CURRENT ALZHEIMER RESEARCH 12.10(2015):974-983.
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