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Meshless reconstruction method for fluorescence molecular tomography based on compactly supported radial basis function
An, Yu1; Liu, Jie1; Zhang, Guanglei1; Ye, Jinzuo2; Mao, Yamin2; Jiang, Shixin1; Shang, Wenting2; Du, Yang2; Chi, Chongwei2; Tian, Jie2,3
2015-10-01
发表期刊JOURNAL OF BIOMEDICAL OPTICS
卷号20期号:10页码:1-11
文章类型Article
摘要Fluorescence molecular tomography (FMT) is a promising tool in the study of cancer, drug discovery, and disease diagnosis, enabling noninvasive and quantitative imaging of the biodistribution of fluorophores in deep tissues via image reconstruction techniques. Conventional reconstruction methods based on the finiteelement method (FEM) have achieved acceptable stability and efficiency. However, some inherent shortcomings in FEM meshes, such as time consumption in mesh generation and a large discretization error, limit further biomedical application. In this paper, we propose a meshless method for reconstruction of FMT (MM-FMT) using compactly supported radial basis functions (CSRBFs). With CSRBFs, the image domain can be accurately expressed by continuous CSRBFs, avoiding the discretization error to a certain degree. After direct collocation with CSRBFs, the conventional optimization techniques, including Tikhonov, L1-norm iteration shrinkage (L1-IS), and sparsity adaptive matching pursuit, were adopted to solve the meshless reconstruction. To evaluate the performance of the proposed MM-FMT, we performed numerical heterogeneous mouse experiments and in vivo bead-implanted mouse experiments. The results suggest that the proposed MM-FMT method can reduce the position error of the reconstruction result to smaller than 0.4 mm for the double-source case, which is a significant improvement for FMT. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
关键词Fluorescence Molecular Tomography Image Reconstruction Compactly Supported Radial Basis Function
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1117/1.JBO.20.10.105003
关键词[WOS]ELEMENT BASED TOMOGRAPHY ; BIOLUMINESCENCE TOMOGRAPHY ; ALGORITHM ; SPARSITY ; TISSUE ; REGULARIZATION ; TECHNOLOGY ; MICROSCOPY ; SYSTEM
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81571836 ; National Basic Research Program of China (973 Program)(2011CB707700) ; Instrument Developing Project of the Chinese Academy of Sciences(YZ201359) ; Fundamental Research Funds for the Central Universities(2014JBM026 ; China Postdoctoral Science Foundation(2015M570032 ; 81227901 ; 2015JBM026) ; 2015T80155) ; 61231004 ; 61501462)
WOS研究方向Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000366017100010
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10529
专题中国科学院分子影像重点实验室
作者单位1.Beijing Jiaotong Univ, Sch Comp & Informat, Dept Biomed Engn, Beijing 100044, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
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GB/T 7714
An, Yu,Liu, Jie,Zhang, Guanglei,et al. Meshless reconstruction method for fluorescence molecular tomography based on compactly supported radial basis function[J]. JOURNAL OF BIOMEDICAL OPTICS,2015,20(10):1-11.
APA An, Yu.,Liu, Jie.,Zhang, Guanglei.,Ye, Jinzuo.,Mao, Yamin.,...&Tian, Jie.(2015).Meshless reconstruction method for fluorescence molecular tomography based on compactly supported radial basis function.JOURNAL OF BIOMEDICAL OPTICS,20(10),1-11.
MLA An, Yu,et al."Meshless reconstruction method for fluorescence molecular tomography based on compactly supported radial basis function".JOURNAL OF BIOMEDICAL OPTICS 20.10(2015):1-11.
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