CASIA OpenIR  > 中国科学院分子影像重点实验室
Meshless reconstruction method for fluorescence molecular tomography based on compactly supported radial basis function
An, Yu1; Liu, Jie1; Zhang, Guanglei1; Ye, Jinzuo2; Mao, Yamin2; Jiang, Shixin1; Shang, Wenting2; Du, Yang2; Chi, Chongwei2; Tian, Jie2,3
Source PublicationJOURNAL OF BIOMEDICAL OPTICS
2015-10-01
Volume20Issue:10Pages:1-11
SubtypeArticle
AbstractFluorescence molecular tomography (FMT) is a promising tool in the study of cancer, drug discovery, and disease diagnosis, enabling noninvasive and quantitative imaging of the biodistribution of fluorophores in deep tissues via image reconstruction techniques. Conventional reconstruction methods based on the finiteelement method (FEM) have achieved acceptable stability and efficiency. However, some inherent shortcomings in FEM meshes, such as time consumption in mesh generation and a large discretization error, limit further biomedical application. In this paper, we propose a meshless method for reconstruction of FMT (MM-FMT) using compactly supported radial basis functions (CSRBFs). With CSRBFs, the image domain can be accurately expressed by continuous CSRBFs, avoiding the discretization error to a certain degree. After direct collocation with CSRBFs, the conventional optimization techniques, including Tikhonov, L1-norm iteration shrinkage (L1-IS), and sparsity adaptive matching pursuit, were adopted to solve the meshless reconstruction. To evaluate the performance of the proposed MM-FMT, we performed numerical heterogeneous mouse experiments and in vivo bead-implanted mouse experiments. The results suggest that the proposed MM-FMT method can reduce the position error of the reconstruction result to smaller than 0.4 mm for the double-source case, which is a significant improvement for FMT. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
KeywordFluorescence Molecular Tomography Image Reconstruction Compactly Supported Radial Basis Function
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1117/1.JBO.20.10.105003
WOS KeywordELEMENT BASED TOMOGRAPHY ; BIOLUMINESCENCE TOMOGRAPHY ; ALGORITHM ; SPARSITY ; TISSUE ; REGULARIZATION ; TECHNOLOGY ; MICROSCOPY ; SYSTEM
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81571836 ; National Basic Research Program of China (973 Program)(2011CB707700) ; Instrument Developing Project of the Chinese Academy of Sciences(YZ201359) ; Fundamental Research Funds for the Central Universities(2014JBM026 ; China Postdoctoral Science Foundation(2015M570032 ; 81227901 ; 2015JBM026) ; 2015T80155) ; 61231004 ; 61501462)
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000366017100010
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10529
Collection中国科学院分子影像重点实验室
Affiliation1.Beijing Jiaotong Univ, Sch Comp & Informat, Dept Biomed Engn, Beijing 100044, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
An, Yu,Liu, Jie,Zhang, Guanglei,et al. Meshless reconstruction method for fluorescence molecular tomography based on compactly supported radial basis function[J]. JOURNAL OF BIOMEDICAL OPTICS,2015,20(10):1-11.
APA An, Yu.,Liu, Jie.,Zhang, Guanglei.,Ye, Jinzuo.,Mao, Yamin.,...&Tian, Jie.(2015).Meshless reconstruction method for fluorescence molecular tomography based on compactly supported radial basis function.JOURNAL OF BIOMEDICAL OPTICS,20(10),1-11.
MLA An, Yu,et al."Meshless reconstruction method for fluorescence molecular tomography based on compactly supported radial basis function".JOURNAL OF BIOMEDICAL OPTICS 20.10(2015):1-11.
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