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Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics
Jin, Yushen1; Ma, Xibo4; Feng, Shanshan2; Liang, Xiao4; Dai, Zhifei3; Tian, Jie4; Yue, Xiuli2
2015-12-01
发表期刊BIOCONJUGATE CHEMISTRY
卷号26期号:12页码:2530-2541
文章类型Article
摘要Theranostic tantalum oxide nanoparticles (TaO(x)NPs) of about 40 nm were successfully developed by conjugating functional molecules including polyethylene glycol (PEG), near-infrared (NIR) fluorescent dye, doxorubicin (DOX), and hyaluronic acid (HA) onto the surface of the nanopartides (TaOx@Cy7-DOX-PEG-HA NPs) for actively targeting delivery, pH-responsive drug release, and NIR fluorescence/X-ray CT bimodal imaging. The obtained nanoagent exhibits good biocompatibility, high cumulative release rate in the acidic microenvironments, long blood circulation time, and superior tumor-targeting ability. Both in vitro and in vivo experiments show that it can serve as an excellent contrast agent to simultaneously enhance fluorescence imaging and CT imaging greatly. Most importantly, such a nanoagent could enhance the therapeutic efficacy of the tumor greatly and the tumor growth inhibition was evaluated to be 87.5%. In a word, multifunctional TaOx@Cy7-DOX-PEG-HA NPs can serve as a theranostic nanomedicine for fluorescence/X-ray CT bimodal imaging, remote-controlled therapeutics, enabling personalized detection, and treatment of cancer with high efficacy.
关键词Hyaluronic Tantalum Oxide Nanoparticles Conjugating
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1021/acs.bioconjchem.5b00551
关键词[WOS]MESOPOROUS SILICA NANOPARTICLES ; RAY COMPUTED-TOMOGRAPHY ; BREAST-CANCER ; PHOTOTHERMAL THERAPY ; ANTICANCER DRUG ; CHEMOTHERAPY ; CD44 ; RELEASE ; MOLECULES ; MIGRATION
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81371580 ; State Key Program of National Nature Science of China(81230036) ; National Natural Science Foundation for Distinguished Young Scholars(81225011) ; 21273014)
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
WOS记录号WOS:000366877400027
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10653
专题中国科学院分子影像重点实验室
通讯作者Yue, Xiuli
作者单位1.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China
2.Harbin Inst Technol, Sch Municipal & Environm Engn, Harbin 150001, Peoples R China
3.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
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GB/T 7714
Jin, Yushen,Ma, Xibo,Feng, Shanshan,et al. Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics[J]. BIOCONJUGATE CHEMISTRY,2015,26(12):2530-2541.
APA Jin, Yushen.,Ma, Xibo.,Feng, Shanshan.,Liang, Xiao.,Dai, Zhifei.,...&Yue, Xiuli.(2015).Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics.BIOCONJUGATE CHEMISTRY,26(12),2530-2541.
MLA Jin, Yushen,et al."Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics".BIOCONJUGATE CHEMISTRY 26.12(2015):2530-2541.
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