CASIA OpenIR  > 中国科学院分子影像重点实验室
Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics
Jin, Yushen1; Ma, Xibo4; Feng, Shanshan2; Liang, Xiao4; Dai, Zhifei3; Tian, Jie4; Yue, Xiuli2
Source PublicationBIOCONJUGATE CHEMISTRY
2015-12-01
Volume26Issue:12Pages:2530-2541
SubtypeArticle
AbstractTheranostic tantalum oxide nanoparticles (TaO(x)NPs) of about 40 nm were successfully developed by conjugating functional molecules including polyethylene glycol (PEG), near-infrared (NIR) fluorescent dye, doxorubicin (DOX), and hyaluronic acid (HA) onto the surface of the nanopartides (TaOx@Cy7-DOX-PEG-HA NPs) for actively targeting delivery, pH-responsive drug release, and NIR fluorescence/X-ray CT bimodal imaging. The obtained nanoagent exhibits good biocompatibility, high cumulative release rate in the acidic microenvironments, long blood circulation time, and superior tumor-targeting ability. Both in vitro and in vivo experiments show that it can serve as an excellent contrast agent to simultaneously enhance fluorescence imaging and CT imaging greatly. Most importantly, such a nanoagent could enhance the therapeutic efficacy of the tumor greatly and the tumor growth inhibition was evaluated to be 87.5%. In a word, multifunctional TaOx@Cy7-DOX-PEG-HA NPs can serve as a theranostic nanomedicine for fluorescence/X-ray CT bimodal imaging, remote-controlled therapeutics, enabling personalized detection, and treatment of cancer with high efficacy.
KeywordHyaluronic Tantalum Oxide Nanoparticles Conjugating
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1021/acs.bioconjchem.5b00551
WOS KeywordMESOPOROUS SILICA NANOPARTICLES ; RAY COMPUTED-TOMOGRAPHY ; BREAST-CANCER ; PHOTOTHERMAL THERAPY ; ANTICANCER DRUG ; CHEMOTHERAPY ; CD44 ; RELEASE ; MOLECULES ; MIGRATION
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81371580 ; State Key Program of National Nature Science of China(81230036) ; National Natural Science Foundation for Distinguished Young Scholars(81225011) ; 21273014)
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
WOS IDWOS:000366877400027
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10653
Collection中国科学院分子影像重点实验室
Corresponding AuthorYue, Xiuli
Affiliation1.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China
2.Harbin Inst Technol, Sch Municipal & Environm Engn, Harbin 150001, Peoples R China
3.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Jin, Yushen,Ma, Xibo,Feng, Shanshan,et al. Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics[J]. BIOCONJUGATE CHEMISTRY,2015,26(12):2530-2541.
APA Jin, Yushen.,Ma, Xibo.,Feng, Shanshan.,Liang, Xiao.,Dai, Zhifei.,...&Yue, Xiuli.(2015).Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics.BIOCONJUGATE CHEMISTRY,26(12),2530-2541.
MLA Jin, Yushen,et al."Hyaluronic Acid Modified Tantalum Oxide Nanoparticles Conjugating Doxorubicin for Targeted Cancer Theranostics".BIOCONJUGATE CHEMISTRY 26.12(2015):2530-2541.
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