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Polarization-sensitive optical projection tomography for muscle fiber imaging
Fang, Mengjie1,2; Dong, Di1,2; Zeng, Chaoting3; Liang, Xiao1,2; Yang, Xin1,2; Arranz, Alicia4; Ripoll, Jorge5; Hui, Hui1,2; Tian, Jie1,2; Hui Hui, Jie Tian
2016-01-11
发表期刊SCIENTIFIC REPORTS
卷号6页码:19241
文章类型Article
摘要Optical projection tomography (OPT) is a tool used for three-dimensional imaging of millimeter-scale biological samples, with the advantage of exhibiting isotropic resolution typically in the micron range. OPT can be divided into two types: transmission OPT (tOPT) and emission OPT (eOPT). Compared with eOPT, tOPT discriminates different tissues based on their absorption coefficient, either intrinsic or after specific staining. However, it fails to distinguish muscle fibers whose absorption coefficients are similar to surrounding tissues. To circumvent this problem, in this article we demonstrate a polarization sensitive OPT system which improves the detection and 3D imaging of muscle fibers by using polarized light. We also developed image acquisition and processing protocols that, together with the system, enable the clear visualization of muscles. Experimental results show that the muscle fibers of diaphragm and stomach, difficult to be distinguished in regular tOPT, were clearly displayed in our system, proving its potential use. Moreover, polarization sensitive OPT was fused with tOPT to investigate the stomach tissue comprehensively. Future applications of polarization sensitive OPT could be imaging other fiber-like structures such as myocardium or other tissues presenting high optical anisotropy.
WOS标题词Science & Technology
DOI10.1038/srep19241
关键词[WOS]IN-VIVO ; COHERENCE TOMOGRAPHY ; BRAIN ; LIGHT ; MICROSCOPY ; SCATTERING ; COLLAGEN ; TISSUE ; MASS
收录类别SCI
语种英语
项目资助者National Basic Research Program of China (973 Program)(2011CB707700) ; National Natural Science Foundation of China(81227901 ; Chinese Academy of Sciences(2010Y2GA03 ; Marie Curie Intra-European Fellowship program(IEF-2010-275137) ; EC ; Spanish MINECO project(FIS2013-41802-R) ; 61231004 ; 2013Y1GA0004 ; 81501616 ; 2012T1G0036 ; 81301346 ; 2013T1G0013 ; 81527805) ; YZ201502 ; YZ201457 ; XDB02060010)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000368150800001
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10665
专题中国科学院分子影像重点实验室
通讯作者Hui Hui, Jie Tian
作者单位1.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Southern Med Univ, Dept Hepatobiliary Surg, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China
4.CSIC UAM, Ctr Mol Biol Severo Ochoa, Madrid 28049, Spain
5.Univ Carlos III Madrid, Dept Bioengn & Aerosp Engn, Madrid 28911, Spain
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Fang, Mengjie,Dong, Di,Zeng, Chaoting,et al. Polarization-sensitive optical projection tomography for muscle fiber imaging[J]. SCIENTIFIC REPORTS,2016,6:19241.
APA Fang, Mengjie.,Dong, Di.,Zeng, Chaoting.,Liang, Xiao.,Yang, Xin.,...&Hui Hui, Jie Tian.(2016).Polarization-sensitive optical projection tomography for muscle fiber imaging.SCIENTIFIC REPORTS,6,19241.
MLA Fang, Mengjie,et al."Polarization-sensitive optical projection tomography for muscle fiber imaging".SCIENTIFIC REPORTS 6(2016):19241.
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