Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population

doi:10.1038/tp.2015.202

	Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population
	Li, Y.1; Xie, S.2,3 ; Liu, B.2,3 ; Song, M.2,3 ; Chen, Y.4; Li, P.5,6; Lu, L.5,6; Lv, L.7,8; Wang, H.4; Yan, H.5,6; Yan, J.5,6 ; Zhang, H.7,9; Zhang, D.5,6,10; Jiang, T.1,2,3,11,12
发表期刊	TRANSLATIONAL PSYCHIATRY
	2016-01-19
卷号	6
文章类型	Article
摘要	Schizophrenia has increasingly been considered a neurodevelopmental disorder, and the advancement of neuroimaging techniques and associated computational methods has enabled quantitative re-examination of this important theory on the pathogenesis of the disease. Inspired by previous findings from neonatal brains, we proposed that an increase in diffusion magnetic resonance imaging (dMRI) mean diffusivity (MD) should be observed in the cerebral cortex of schizophrenia patients compared with healthy controls, corresponding to lower tissue complexity and potentially a failure to reach cortical maturation. We tested this hypothesis using dMRI data from a Chinese Han population comprising patients from four different hospital sites. Utilizing data-driven methods based on the state-of-the-art tensor-based registration algorithm, significantly increased MD measurements were consistently observed in the cortex of schizophrenia patients across all four sites, despite differences in psychopathology, exposure to antipsychotic medication and scanners used for image acquisition. Specifically, we found increased MD in the limbic system of the schizophrenic brain, mainly involving the bilateral insular and prefrontal cortices. In light of the existing literature, we speculate that this may represent a neuroanatomical signature of the disorder, reflecting microstructural deficits due to developmental abnormalities. Our findings not only provide strong support to the abnormal neurodevelopment theory of schizophrenia, but also highlight an important neuroimaging endophenotype for monitoring the developmental trajectory of high-risk subjects of the disease, thereby facilitating early detection and prevention.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1038/tp.2015.202
关键词[WOS]	INDEPENDENT COMPONENT ANALYSIS ; WHITE-MATTER ABNORMALITIES ; HUMAN CEREBRAL-CORTEX ; HUMAN BRAIN ; DISCRIMINATING SCHIZOPHRENIA ; RETHINKING SCHIZOPHRENIA ; VOLUME REDUCTION ; WATER DIFFUSION ; METAANALYSIS ; FMRI
收录类别	SCI
语种	英语
项目资助者	National Basic Research Program of China (973 program)(2011CB707805) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91132301 ; 91432302)
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000368584200003
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/10668
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Peoples R China 5.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100871, Peoples R China 6.Peking Univ, Key Lab Mental Hlth, Beijing 100871, Peoples R China 7.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang, Peoples R China 8.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China 9.Xinxiang Med Univ, Dept Psychol, Xinxiang, Peoples R China 10.Peking Univ, McGovern Inst Brain Res, Ctr Life Sci, PKU,IDG, Beijing 100871, Peoples R China 11.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 12.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Y.,Xie, S.,Liu, B.,et al. Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population[J]. TRANSLATIONAL PSYCHIATRY,2016,6.
APA	Li, Y..,Xie, S..,Liu, B..,Song, M..,Chen, Y..,...&Jiang, T..(2016).Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population.TRANSLATIONAL PSYCHIATRY,6.
MLA	Li, Y.,et al."Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population".TRANSLATIONAL PSYCHIATRY 6(2016).

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