Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population | |
Li, Y.1; Xie, S.2,3; Liu, B.2,3; Song, M.2,3; Chen, Y.4; Li, P.5,6; Lu, L.5,6; Lv, L.7,8; Wang, H.4; Yan, H.5,6; Yan, J.5,6; Zhang, H.7,9; Zhang, D.5,6,10; Jiang, T.1,2,3,11,12 | |
发表期刊 | TRANSLATIONAL PSYCHIATRY |
2016-01-19 | |
卷号 | 6 |
文章类型 | Article |
摘要 | Schizophrenia has increasingly been considered a neurodevelopmental disorder, and the advancement of neuroimaging techniques and associated computational methods has enabled quantitative re-examination of this important theory on the pathogenesis of the disease. Inspired by previous findings from neonatal brains, we proposed that an increase in diffusion magnetic resonance imaging (dMRI) mean diffusivity (MD) should be observed in the cerebral cortex of schizophrenia patients compared with healthy controls, corresponding to lower tissue complexity and potentially a failure to reach cortical maturation. We tested this hypothesis using dMRI data from a Chinese Han population comprising patients from four different hospital sites. Utilizing data-driven methods based on the state-of-the-art tensor-based registration algorithm, significantly increased MD measurements were consistently observed in the cortex of schizophrenia patients across all four sites, despite differences in psychopathology, exposure to antipsychotic medication and scanners used for image acquisition. Specifically, we found increased MD in the limbic system of the schizophrenic brain, mainly involving the bilateral insular and prefrontal cortices. In light of the existing literature, we speculate that this may represent a neuroanatomical signature of the disorder, reflecting microstructural deficits due to developmental abnormalities. Our findings not only provide strong support to the abnormal neurodevelopment theory of schizophrenia, but also highlight an important neuroimaging endophenotype for monitoring the developmental trajectory of high-risk subjects of the disease, thereby facilitating early detection and prevention. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1038/tp.2015.202 |
关键词[WOS] | INDEPENDENT COMPONENT ANALYSIS ; WHITE-MATTER ABNORMALITIES ; HUMAN CEREBRAL-CORTEX ; HUMAN BRAIN ; DISCRIMINATING SCHIZOPHRENIA ; RETHINKING SCHIZOPHRENIA ; VOLUME REDUCTION ; WATER DIFFUSION ; METAANALYSIS ; FMRI |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | National Basic Research Program of China (973 program)(2011CB707805) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91132301 ; 91432302) |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000368584200003 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/10668 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 1.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Peoples R China 5.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100871, Peoples R China 6.Peking Univ, Key Lab Mental Hlth, Beijing 100871, Peoples R China 7.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang, Peoples R China 8.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China 9.Xinxiang Med Univ, Dept Psychol, Xinxiang, Peoples R China 10.Peking Univ, McGovern Inst Brain Res, Ctr Life Sci, PKU,IDG, Beijing 100871, Peoples R China 11.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 12.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Y.,Xie, S.,Liu, B.,et al. Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population[J]. TRANSLATIONAL PSYCHIATRY,2016,6. |
APA | Li, Y..,Xie, S..,Liu, B..,Song, M..,Chen, Y..,...&Jiang, T..(2016).Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population.TRANSLATIONAL PSYCHIATRY,6. |
MLA | Li, Y.,et al."Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population".TRANSLATIONAL PSYCHIATRY 6(2016). |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Xie-2016-Transl Psyc(2862KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
个性服务 |
推荐该条目 |
保存到收藏夹 |
查看访问统计 |
导出为Endnote文件 |
谷歌学术 |
谷歌学术中相似的文章 |
[Li, Y.]的文章 |
[Xie, S.]的文章 |
[Liu, B.]的文章 |
百度学术 |
百度学术中相似的文章 |
[Li, Y.]的文章 |
[Xie, S.]的文章 |
[Liu, B.]的文章 |
必应学术 |
必应学术中相似的文章 |
[Li, Y.]的文章 |
[Xie, S.]的文章 |
[Liu, B.]的文章 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论