CASIA OpenIR  > 脑网络组研究中心
Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population
Li, Y.1; Xie, S.2,3; Liu, B.2,3; Song, M.2,3; Chen, Y.4; Li, P.5,6; Lu, L.5,6; Lv, L.7,8; Wang, H.4; Yan, H.5,6; Yan, J.5,6; Zhang, H.7,9; Zhang, D.5,6,10; Jiang, T.1,2,3,11,12
2016-01-19
发表期刊TRANSLATIONAL PSYCHIATRY
卷号6
文章类型Article
摘要Schizophrenia has increasingly been considered a neurodevelopmental disorder, and the advancement of neuroimaging techniques and associated computational methods has enabled quantitative re-examination of this important theory on the pathogenesis of the disease. Inspired by previous findings from neonatal brains, we proposed that an increase in diffusion magnetic resonance imaging (dMRI) mean diffusivity (MD) should be observed in the cerebral cortex of schizophrenia patients compared with healthy controls, corresponding to lower tissue complexity and potentially a failure to reach cortical maturation. We tested this hypothesis using dMRI data from a Chinese Han population comprising patients from four different hospital sites. Utilizing data-driven methods based on the state-of-the-art tensor-based registration algorithm, significantly increased MD measurements were consistently observed in the cortex of schizophrenia patients across all four sites, despite differences in psychopathology, exposure to antipsychotic medication and scanners used for image acquisition. Specifically, we found increased MD in the limbic system of the schizophrenic brain, mainly involving the bilateral insular and prefrontal cortices. In light of the existing literature, we speculate that this may represent a neuroanatomical signature of the disorder, reflecting microstructural deficits due to developmental abnormalities. Our findings not only provide strong support to the abnormal neurodevelopment theory of schizophrenia, but also highlight an important neuroimaging endophenotype for monitoring the developmental trajectory of high-risk subjects of the disease, thereby facilitating early detection and prevention.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1038/tp.2015.202
关键词[WOS]INDEPENDENT COMPONENT ANALYSIS ; WHITE-MATTER ABNORMALITIES ; HUMAN CEREBRAL-CORTEX ; HUMAN BRAIN ; DISCRIMINATING SCHIZOPHRENIA ; RETHINKING SCHIZOPHRENIA ; VOLUME REDUCTION ; WATER DIFFUSION ; METAANALYSIS ; FMRI
收录类别SCI
语种英语
项目资助者National Basic Research Program of China (973 program)(2011CB707805) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91132301 ; 91432302)
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000368584200003
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10668
专题脑网络组研究中心
作者单位1.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Peoples R China
5.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100871, Peoples R China
6.Peking Univ, Key Lab Mental Hlth, Beijing 100871, Peoples R China
7.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang, Peoples R China
8.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China
9.Xinxiang Med Univ, Dept Psychol, Xinxiang, Peoples R China
10.Peking Univ, McGovern Inst Brain Res, Ctr Life Sci, PKU,IDG, Beijing 100871, Peoples R China
11.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
12.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Li, Y.,Xie, S.,Liu, B.,et al. Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population[J]. TRANSLATIONAL PSYCHIATRY,2016,6.
APA Li, Y..,Xie, S..,Liu, B..,Song, M..,Chen, Y..,...&Jiang, T..(2016).Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population.TRANSLATIONAL PSYCHIATRY,6.
MLA Li, Y.,et al."Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population".TRANSLATIONAL PSYCHIATRY 6(2016).
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Xie-2016-Transl Psyc(2862KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Y.]的文章
[Xie, S.]的文章
[Liu, B.]的文章
百度学术
百度学术中相似的文章
[Li, Y.]的文章
[Xie, S.]的文章
[Liu, B.]的文章
必应学术
必应学术中相似的文章
[Li, Y.]的文章
[Xie, S.]的文章
[Liu, B.]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Xie-2016-Transl Psychiatry-Multi-site dMRI study of schizophrenia.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。