CASIA OpenIR  > 脑网络组研究中心
Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population
Li, Y.1; Xie, S.2,3; Liu, B.2,3; Song, M.2,3; Chen, Y.4; Li, P.5,6; Lu, L.5,6; Lv, L.7,8; Wang, H.4; Yan, H.5,6; Yan, J.5,6; Zhang, H.7,9; Zhang, D.5,6,10; Jiang, T.1,2,3,11,12
Source PublicationTRANSLATIONAL PSYCHIATRY
2016-01-19
Volume6
SubtypeArticle
AbstractSchizophrenia has increasingly been considered a neurodevelopmental disorder, and the advancement of neuroimaging techniques and associated computational methods has enabled quantitative re-examination of this important theory on the pathogenesis of the disease. Inspired by previous findings from neonatal brains, we proposed that an increase in diffusion magnetic resonance imaging (dMRI) mean diffusivity (MD) should be observed in the cerebral cortex of schizophrenia patients compared with healthy controls, corresponding to lower tissue complexity and potentially a failure to reach cortical maturation. We tested this hypothesis using dMRI data from a Chinese Han population comprising patients from four different hospital sites. Utilizing data-driven methods based on the state-of-the-art tensor-based registration algorithm, significantly increased MD measurements were consistently observed in the cortex of schizophrenia patients across all four sites, despite differences in psychopathology, exposure to antipsychotic medication and scanners used for image acquisition. Specifically, we found increased MD in the limbic system of the schizophrenic brain, mainly involving the bilateral insular and prefrontal cortices. In light of the existing literature, we speculate that this may represent a neuroanatomical signature of the disorder, reflecting microstructural deficits due to developmental abnormalities. Our findings not only provide strong support to the abnormal neurodevelopment theory of schizophrenia, but also highlight an important neuroimaging endophenotype for monitoring the developmental trajectory of high-risk subjects of the disease, thereby facilitating early detection and prevention.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1038/tp.2015.202
WOS KeywordINDEPENDENT COMPONENT ANALYSIS ; WHITE-MATTER ABNORMALITIES ; HUMAN CEREBRAL-CORTEX ; HUMAN BRAIN ; DISCRIMINATING SCHIZOPHRENIA ; RETHINKING SCHIZOPHRENIA ; VOLUME REDUCTION ; WATER DIFFUSION ; METAANALYSIS ; FMRI
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of China (973 program)(2011CB707805) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91132301 ; 91432302)
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000368584200003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10668
Collection脑网络组研究中心
Affiliation1.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Peoples R China
5.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100871, Peoples R China
6.Peking Univ, Key Lab Mental Hlth, Beijing 100871, Peoples R China
7.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang, Peoples R China
8.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China
9.Xinxiang Med Univ, Dept Psychol, Xinxiang, Peoples R China
10.Peking Univ, McGovern Inst Brain Res, Ctr Life Sci, PKU,IDG, Beijing 100871, Peoples R China
11.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
12.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, Y.,Xie, S.,Liu, B.,et al. Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population[J]. TRANSLATIONAL PSYCHIATRY,2016,6.
APA Li, Y..,Xie, S..,Liu, B..,Song, M..,Chen, Y..,...&Jiang, T..(2016).Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population.TRANSLATIONAL PSYCHIATRY,6.
MLA Li, Y.,et al."Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population".TRANSLATIONAL PSYCHIATRY 6(2016).
Files in This Item: Download All
File Name/Size DocType Version Access License
Xie-2016-Transl Psyc(2862KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Y.]'s Articles
[Xie, S.]'s Articles
[Liu, B.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Y.]'s Articles
[Xie, S.]'s Articles
[Liu, B.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Y.]'s Articles
[Xie, S.]'s Articles
[Liu, B.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Xie-2016-Transl Psychiatry-Multi-site dMRI study of schizophrenia.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.