Structural brain alterations in primary open angle glaucoma: a 3T MRI study
Wang, Jieqiong1; Li, Ting2; Sabel, Bernhard A.3; Chen, Zhiqiang1,4; Wen, Hongwei1,4; Li, Jianhong2; Xie, Xiaobin5; Yang, Diya5; Chen, Weiwei5; Wang, Ningli5; Xian, Junfang2; He, Huiguang1,4
Source PublicationSCIENTIFIC REPORTS
2016-01-08
Volume6Issue:*Pages:*
SubtypeArticle
AbstractGlaucoma is not only an eye disease but is also associated with degeneration of brain structures. We now investigated the pattern of visual and non-visual brain structural changes in 25 primary open angle glaucoma (POAG) patients and 25 age-gender-matched normal controls using T1-weighted imaging. MRI images were subjected to volume-based analysis (VBA) and surface-based analysis (SBA) in the whole brain as well as ROI-based analysis of the lateral geniculate nucleus (LGN), visual cortex (V1/2), amygdala and hippocampus. While VBA showed no significant differences in the gray matter volumes of patients, SBA revealed significantly reduced cortical thickness in the right frontal pole and ROI-based analysis volume shrinkage in LGN bilaterally, right V1 and left amygdala. Structural abnormalities were correlated with clinical parameters in a subset of the patients revealing that the left LGN volume was negatively correlated with bilateral cup-to-disk ratio (CDR), the right LGN volume was positively correlated with the mean deviation of the right visual hemifield, and the right V1 cortical thickness was negatively correlated with the right CDR in glaucoma. These results demonstrate that POAG affects both vision-related structures and non-visual cortical regions. Moreover, alterations of the brain visual structures reflect the clinical severity of glaucoma.
KeywordPrimary Open Angle Glaucoma
WOS HeadingsScience & Technology
DOI10.1038/srep18969
WOS KeywordOPTICAL COHERENCE TOMOGRAPHY ; LATERAL GENICULATE-NUCLEUS ; VOXEL-BASED MORPHOMETRY ; HUMAN CEREBRAL-CORTEX ; DIFFUSION-TENSOR MR ; NERVE-FIBER LAYER ; VISUAL-CORTEX ; ALZHEIMERS-DISEASE ; AREAS V1 ; THICKNESS
Indexed BySCI
Language英语
Funding Organization863 Projects(2013AA013803) ; National Natural Science Foundation of China(61271151 ; Youth Innovation Promotion Association CAS ; BMBF network ERA-net Neuron "Restoration of Vision after Stroke (REVIS)"(BMBF 01EW1210) ; "Hai-ju" Beijing Overseas Talents Program ; 61228103)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000368684100001
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Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10669
Collection复杂系统管理与控制国家重点实验室_影像分析与机器视觉
Affiliation1.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
2.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing, Peoples R China
3.Univ Magdeburg, Fac Med, Inst Med Psychol, Dept Med Psychol, D-39106 Magdeburg, Germany
4.Chinese Acad Sci, Inst Automat, Res Ctr Brain Inspired Intelligence, Beijing, Peoples R China
5.Capital Med Univ, Beijing Tongren Hosp, Dept Ophthalmol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jieqiong,Li, Ting,Sabel, Bernhard A.,et al. Structural brain alterations in primary open angle glaucoma: a 3T MRI study[J]. SCIENTIFIC REPORTS,2016,6(*):*.
APA Wang, Jieqiong.,Li, Ting.,Sabel, Bernhard A..,Chen, Zhiqiang.,Wen, Hongwei.,...&He, Huiguang.(2016).Structural brain alterations in primary open angle glaucoma: a 3T MRI study.SCIENTIFIC REPORTS,6(*),*.
MLA Wang, Jieqiong,et al."Structural brain alterations in primary open angle glaucoma: a 3T MRI study".SCIENTIFIC REPORTS 6.*(2016):*.
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