Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents
Li, Wenjing1,2,3; Li, Jianhong4; Wang, Jieqiong2; Zhou, Peng2; Wang, Zhenchang5; Xian, Junfang4; He, Huiguang2
Source PublicationNEURAL PLASTICITY
2016
SubtypeArticle
AbstractPrevious neuroimaging studies suggested structural or functional brain reorganizations occurred in prelingually deaf subjects. However, little is known about the reorganizations of brain network architectures in prelingually deaf adolescents. The present study aims to investigate alterations of whole-brain functional network using resting-state fMRI and graph theory analysis. We recruited 16 prelingually deaf adolescents (10 similar to 18 years) and 16 normal controls matched in age and gender. Brain networks were constructed from mean time courses of 90 regions. Widely distributed network was observed in deaf subjects, with increased connectivity between the limbic system and regions involved in visual and language processing, suggesting reinforcement of the processing for the visual and verbal information in deaf adolescents. Decreased connectivity was detected between the visual regions and language regions possibly due to inferior reading or speaking skills in deaf subjects. Using graph theory analysis, we demonstrated small-worldness property did not change in prelingually deaf adolescents relative to normal controls. However, compared with healthy adolescents, eight regions involved in visual, language, and auditory processing were identified as hubs only present in prelingually deaf adolescents. These findings revealed reorganization of brain functional networks occurred in prelingually deaf adolescents to adapt to deficient auditory input.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1155/2016/9849087
WOS KeywordCORTICAL THICKNESS ANALYSIS ; GRAPH-THEORETICAL ANALYSIS ; SUPERIOR TEMPORAL GYRUS ; VOXEL-BASED MORPHOMETRY ; INFERIOR FRONTAL GYRUS ; SMALL-WORLD NETWORKS ; VISUAL-CORTEX ; SIGN-LANGUAGE ; ADULTS ; SCHIZOPHRENIA
Indexed BySCI
Language英语
Funding Organization863 Project(2013AA013803) ; National Natural Science Foundation of China (NSFC)(81271557 ; Youth Innovation Promotion Association CAS ; Beijing Postdoctoral Research Foundation(2014ZZ-8) ; Project Funded by China Postdoctoral Science Foundation(2015M570911) ; Basic Research Foundation Project of Beijing University of Technology ; 61271151 ; 61228103)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000368880300001
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10674
Collection复杂系统管理与控制国家重点实验室_影像分析与机器视觉
Affiliation1.Beijing Univ Technol, Coll Elect Informat & Control Engn, Beijing 100124, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
3.Beijing Key Lab Computat Intelligence & Intellige, Beijing 100124, Peoples R China
4.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing 100730, Peoples R China
5.Capital Med Univ, Beijing Friendship Hosp, Dept Radiol, Beijing 100050, Peoples R China
Recommended Citation
GB/T 7714
Li, Wenjing,Li, Jianhong,Wang, Jieqiong,et al. Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents[J]. NEURAL PLASTICITY,2016.
APA Li, Wenjing.,Li, Jianhong.,Wang, Jieqiong.,Zhou, Peng.,Wang, Zhenchang.,...&He, Huiguang.(2016).Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents.NEURAL PLASTICITY.
MLA Li, Wenjing,et al."Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents".NEURAL PLASTICITY (2016).
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