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Hybrid simplified spherical harmonics with diffusion equation for light propagation in tissues
Chen, Xueli1,2; Sun, Fangfang1,2; Yang, Defu1,2; Ren, Shenghan1,2; Zhang, Qian3; Liang, Jimin1,2
Source PublicationPHYSICS IN MEDICINE AND BIOLOGY
2015-08-21
Volume60Issue:16Pages:6305-6322
SubtypeArticle
AbstractAiming at the limitations of the simplified spherical harmonics approximation (SPN) and diffusion equation (DE) in describing the light propagation in tissues, a hybrid simplified spherical harmonics with diffusion equation (HSDE) based diffuse light transport model is proposed. In the HSDE model, the living body is first segmented into several major organs, and then the organs are divided into high scattering tissues and other tissues. DE and SPN are employed to describe the light propagation in these two kinds of tissues respectively, which are finally coupled using the established boundary coupling condition. The HSDE model makes full use of the advantages of SPN and DE, and abandons their disadvantages, so that it can provide a perfect balance between accuracy and computation time. Using the finite element method, the HSDE is solved for light flux density map on body surface. The accuracy and efficiency of the HSDE are validated with both regular geometries and digital mouse model based simulations. Corresponding results reveal that a comparable accuracy and much less computation time are achieved compared with the SPN model as well as a much better accuracy compared with the DE one.
KeywordHybrid Light Transport Model Spn De Hsde Fluorescence/bioluminescence Tomography
WOS HeadingsScience & Technology ; Technology ; Life Sciences & Biomedicine
DOI10.1088/0031-9155/60/16/6305
WOS KeywordFLUORESCENCE MOLECULAR TOMOGRAPHY ; RADIATIVE-TRANSFER EQUATION ; NON-SCATTERING REGIONS ; BIOLUMINESCENCE TOMOGRAPHY ; OPTICAL TOMOGRAPHY ; IN-VIVO ; IMAGE-RECONSTRUCTION ; PHOTON MIGRATION ; TURBID MEDIA ; APPROXIMATION
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectEngineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000361052600011
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10741
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xueli,Sun, Fangfang,Yang, Defu,et al. Hybrid simplified spherical harmonics with diffusion equation for light propagation in tissues[J]. PHYSICS IN MEDICINE AND BIOLOGY,2015,60(16):6305-6322.
APA Chen, Xueli,Sun, Fangfang,Yang, Defu,Ren, Shenghan,Zhang, Qian,&Liang, Jimin.(2015).Hybrid simplified spherical harmonics with diffusion equation for light propagation in tissues.PHYSICS IN MEDICINE AND BIOLOGY,60(16),6305-6322.
MLA Chen, Xueli,et al."Hybrid simplified spherical harmonics with diffusion equation for light propagation in tissues".PHYSICS IN MEDICINE AND BIOLOGY 60.16(2015):6305-6322.
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