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Genetic Effects on Fine-Grained Human Cortical Regionalization
Cui, Yue1,2; Liu, Bing1,2; Zhou, Yuan4,5; Fan, Lingzhong1,2; Li, Jin1,2; Zhang, Yun6; Wu, Huawang6,7; Hou, Bing1,2; Wang, Chao6; Zheng, Fanfan1,2; Qiu, Chengxiang1,2; Rao, Li-Lin4,5; Ning, Yuping7; Li, Shu4,5; Jiang, Tianzi1,2,3,6,8
2016-09-01
发表期刊CEREBRAL CORTEX
卷号26期号:9页码:3732-3743
文章类型Article
摘要Various brain structural and functional features such as cytoarchitecture, topographic mapping, gyral/sulcal anatomy, and anatomical and functional connectivity have been used in human brain parcellation. However, the fine-grained intrinsic genetic architecture of the cortex remains unknown. In the present study, we parcellated specific regions of the cortex into subregions based on genetic correlations (i.e., shared genetic influences) between the surface area of each pair of cortical locations within the seed region. The genetic correlations were estimated by comparing the correlations of the surface area between monozygotic and dizygotic twins using bivariate twin models. Our genetic subdivisions of diverse brain regions were reproducible across 2 independent datasets and corresponded closely to fine-grained functional specializations. Furthermore, subregional genetic correlation profiles were generally consistent with functional connectivity patterns. Our findings indicate that the magnitude of the genetic covariance in brain anatomy could be used to delineate the boundaries of functional subregions of the brain and may be of value in the next generation human brain atlas.
关键词Cortical Regionalization Genetic Correlation Genetics Surface Area Twins
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1093/cercor/bhv176
关键词[WOS]HUMAN CEREBRAL-CORTEX ; CONNECTIVITY-BASED PARCELLATION ; SUPPLEMENTARY MOTOR AREAS ; SURFACE-BASED ANALYSIS ; FRONTAL-CORTEX ; BROCAS REGION ; HUMAN BRAIN ; FUNCTIONAL LOCALIZATION ; PREFRONTAL CORTEX ; WORKING-MEMORY
收录类别SCI
语种英语
项目资助者National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91132301 ; Youth Innovation Promotion Association, Chinese Academy of Science ; 61305143 ; 31170976 ; 31300843)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000384668600006
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10761
专题脑网络组研究中心
作者单位1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci, Inst Automat, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China
7.Guangzhou Med Univ, Affiliated Brain Hosp, Guangzhou Brain Hosp, Guangzhou 510370, Guangdong, Peoples R China
8.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
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GB/T 7714
Cui, Yue,Liu, Bing,Zhou, Yuan,et al. Genetic Effects on Fine-Grained Human Cortical Regionalization[J]. CEREBRAL CORTEX,2016,26(9):3732-3743.
APA Cui, Yue.,Liu, Bing.,Zhou, Yuan.,Fan, Lingzhong.,Li, Jin.,...&Jiang, Tianzi.(2016).Genetic Effects on Fine-Grained Human Cortical Regionalization.CEREBRAL CORTEX,26(9),3732-3743.
MLA Cui, Yue,et al."Genetic Effects on Fine-Grained Human Cortical Regionalization".CEREBRAL CORTEX 26.9(2016):3732-3743.
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