Genetic Effects on Fine-Grained Human Cortical Regionalization | |
Cui, Yue1,2; Liu, Bing1,2; Zhou, Yuan4,5; Fan, Lingzhong1,2; Li, Jin1,2; Zhang, Yun6; Wu, Huawang6,7; Hou, Bing1,2; Wang, Chao6; Zheng, Fanfan1,2; Qiu, Chengxiang1,2; Rao, Li-Lin4,5; Ning, Yuping7; Li, Shu4,5; Jiang, Tianzi1,2,3,6,8 | |
发表期刊 | CEREBRAL CORTEX |
2016-09-01 | |
卷号 | 26期号:9页码:3732-3743 |
文章类型 | Article |
摘要 | Various brain structural and functional features such as cytoarchitecture, topographic mapping, gyral/sulcal anatomy, and anatomical and functional connectivity have been used in human brain parcellation. However, the fine-grained intrinsic genetic architecture of the cortex remains unknown. In the present study, we parcellated specific regions of the cortex into subregions based on genetic correlations (i.e., shared genetic influences) between the surface area of each pair of cortical locations within the seed region. The genetic correlations were estimated by comparing the correlations of the surface area between monozygotic and dizygotic twins using bivariate twin models. Our genetic subdivisions of diverse brain regions were reproducible across 2 independent datasets and corresponded closely to fine-grained functional specializations. Furthermore, subregional genetic correlation profiles were generally consistent with functional connectivity patterns. Our findings indicate that the magnitude of the genetic covariance in brain anatomy could be used to delineate the boundaries of functional subregions of the brain and may be of value in the next generation human brain atlas. |
关键词 | Cortical Regionalization Genetic Correlation Genetics Surface Area Twins |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1093/cercor/bhv176 |
关键词[WOS] | HUMAN CEREBRAL-CORTEX ; CONNECTIVITY-BASED PARCELLATION ; SUPPLEMENTARY MOTOR AREAS ; SURFACE-BASED ANALYSIS ; FRONTAL-CORTEX ; BROCAS REGION ; HUMAN BRAIN ; FUNCTIONAL LOCALIZATION ; PREFRONTAL CORTEX ; WORKING-MEMORY |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91132301 ; Youth Innovation Promotion Association, Chinese Academy of Science ; 61305143 ; 31170976 ; 31300843) |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000384668600006 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/10761 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci, Inst Automat, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 7.Guangzhou Med Univ, Affiliated Brain Hosp, Guangzhou Brain Hosp, Guangzhou 510370, Guangdong, Peoples R China 8.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia |
第一作者单位 | 模式识别国家重点实验室 |
推荐引用方式 GB/T 7714 | Cui, Yue,Liu, Bing,Zhou, Yuan,et al. Genetic Effects on Fine-Grained Human Cortical Regionalization[J]. CEREBRAL CORTEX,2016,26(9):3732-3743. |
APA | Cui, Yue.,Liu, Bing.,Zhou, Yuan.,Fan, Lingzhong.,Li, Jin.,...&Jiang, Tianzi.(2016).Genetic Effects on Fine-Grained Human Cortical Regionalization.CEREBRAL CORTEX,26(9),3732-3743. |
MLA | Cui, Yue,et al."Genetic Effects on Fine-Grained Human Cortical Regionalization".CEREBRAL CORTEX 26.9(2016):3732-3743. |
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