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Interaction of COMT rs4680 and BDNF rs6265 Polymorphisms on Functional Connectivity Density of the Left Frontal Eye Field in Healthy Young Adults
Li, Wei1,2; Liu, Bing3; Xu, Jiayuan1,2; Jiang, Tianzi3; Yu, Chunshui1,2
2016-07-01
发表期刊HUMAN BRAIN MAPPING
卷号37期号:7页码:2468-2478
文章类型Article
摘要As modulators of dopamine availability and release in the brain, COMT and BDNF polymorphisms have demonstrated interactions on human cognition; however, the underlying neural mechanisms remain largely unknown. In this study, we aimed to investigate the interactions of COMT rs4680 and BDNF rs6265 on global functional connectivity density (gFCD) of the brain in 265 healthy young subjects. We found a significant COMT x BDNF interaction on the gFCD in the left frontal eye field (FEF), showing an inverted U-shape modulation by the presumed dopamine signaling. This finding was consistently repeated in the gFCD analyses using other four connection thresholds. Our findings reveal a COMT x BDNF interaction on the FCD in the left FEF, which may be helpful for understanding the neural mechanisms of the COMT x BDNF interactions on the FEF-related cognitive functions. (C) 2016 Wiley Periodicals, Inc.
关键词Comt Bdnf Functional Connectivity Density Dopamine Attention
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1002/hbm.23187
关键词[WOS]CATECHOL-O-METHYLTRANSFERASE ; DEFICIT HYPERACTIVITY DISORDER ; ACTIVITY-DEPENDENT SECRETION ; NEUROTROPHIC-FACTOR ; VAL66MET POLYMORPHISM ; HUMAN BRAIN ; TOP-DOWN ; DRD2 POLYMORPHISMS ; COGNITIVE-ABILITY ; GENE POLYMORPHISM
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(81425013 ; 91332113 ; 81271551 ; 81301201 ; 81301202)
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000382488800009
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10822
专题脑网络组研究中心
作者单位1.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
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Li, Wei,Liu, Bing,Xu, Jiayuan,et al. Interaction of COMT rs4680 and BDNF rs6265 Polymorphisms on Functional Connectivity Density of the Left Frontal Eye Field in Healthy Young Adults[J]. HUMAN BRAIN MAPPING,2016,37(7):2468-2478.
APA Li, Wei,Liu, Bing,Xu, Jiayuan,Jiang, Tianzi,&Yu, Chunshui.(2016).Interaction of COMT rs4680 and BDNF rs6265 Polymorphisms on Functional Connectivity Density of the Left Frontal Eye Field in Healthy Young Adults.HUMAN BRAIN MAPPING,37(7),2468-2478.
MLA Li, Wei,et al."Interaction of COMT rs4680 and BDNF rs6265 Polymorphisms on Functional Connectivity Density of the Left Frontal Eye Field in Healthy Young Adults".HUMAN BRAIN MAPPING 37.7(2016):2468-2478.
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