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Interaction of COMT rs4680 and BDNF rs6265 Polymorphisms on Functional Connectivity Density of the Left Frontal Eye Field in Healthy Young Adults
Li, Wei1,2; Liu, Bing3; Xu, Jiayuan1,2; Jiang, Tianzi3; Yu, Chunshui1,2
Source PublicationHUMAN BRAIN MAPPING
2016-07-01
Volume37Issue:7Pages:2468-2478
SubtypeArticle
AbstractAs modulators of dopamine availability and release in the brain, COMT and BDNF polymorphisms have demonstrated interactions on human cognition; however, the underlying neural mechanisms remain largely unknown. In this study, we aimed to investigate the interactions of COMT rs4680 and BDNF rs6265 on global functional connectivity density (gFCD) of the brain in 265 healthy young subjects. We found a significant COMT x BDNF interaction on the gFCD in the left frontal eye field (FEF), showing an inverted U-shape modulation by the presumed dopamine signaling. This finding was consistently repeated in the gFCD analyses using other four connection thresholds. Our findings reveal a COMT x BDNF interaction on the FCD in the left FEF, which may be helpful for understanding the neural mechanisms of the COMT x BDNF interactions on the FEF-related cognitive functions. (C) 2016 Wiley Periodicals, Inc.
KeywordComt Bdnf Functional Connectivity Density Dopamine Attention
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1002/hbm.23187
WOS KeywordCATECHOL-O-METHYLTRANSFERASE ; DEFICIT HYPERACTIVITY DISORDER ; ACTIVITY-DEPENDENT SECRETION ; NEUROTROPHIC-FACTOR ; VAL66MET POLYMORPHISM ; HUMAN BRAIN ; TOP-DOWN ; DRD2 POLYMORPHISMS ; COGNITIVE-ABILITY ; GENE POLYMORPHISM
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81425013 ; 91332113 ; 81271551 ; 81301201 ; 81301202)
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000382488800009
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10822
Collection脑网络组研究中心
Affiliation1.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Li, Wei,Liu, Bing,Xu, Jiayuan,et al. Interaction of COMT rs4680 and BDNF rs6265 Polymorphisms on Functional Connectivity Density of the Left Frontal Eye Field in Healthy Young Adults[J]. HUMAN BRAIN MAPPING,2016,37(7):2468-2478.
APA Li, Wei,Liu, Bing,Xu, Jiayuan,Jiang, Tianzi,&Yu, Chunshui.(2016).Interaction of COMT rs4680 and BDNF rs6265 Polymorphisms on Functional Connectivity Density of the Left Frontal Eye Field in Healthy Young Adults.HUMAN BRAIN MAPPING,37(7),2468-2478.
MLA Li, Wei,et al."Interaction of COMT rs4680 and BDNF rs6265 Polymorphisms on Functional Connectivity Density of the Left Frontal Eye Field in Healthy Young Adults".HUMAN BRAIN MAPPING 37.7(2016):2468-2478.
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