CASIA OpenIR  > 脑网络组研究中心
Impact of PICALM and CLU on Hippocampal Degeneration
Yang, Xianfeng1,2; Li, Jin3,4,5; Liu, Bing3,4,5; Li, Yonghui1; Jiang, Tianzi1,2,3,4,5
2016-07-01
发表期刊HUMAN BRAIN MAPPING
卷号37期号:7页码:2419-2430
文章类型Article
摘要PICALM and CLU are two major risk genes of late-onset Alzheimer's disease (LOAD), and there is strong molecular evidence suggesting their interaction on amyloid-beta deposition, hence finding functional dependency between their risk genotypes may lead to better understanding of their roles in LOAD development and greater clinical utility. In this study, we mainly investigated interaction effects of risk loci PICALM rs3581179 and CLU rs11136000 on hippocampal degeneration in both young and elderly adults in order to understand their neural mechanism on aging process, which may help identify robust biomarkers for early diagnosis and intervention. Besides volume we also assessed hippocampal shape phenotypes derived from diffeomorphic metric mapping and nonlinear dimensionality reduction. In elderly individuals (75.6 +/- 6.7 years) significant interaction effects existed on hippocampal volume (P < 0.001), whereas in young healthy adults (19.4 +/- 1.1 years) such effects existed on a shape phenotype (P = 0.01) indicating significant variation at hippocampal head and tail that mirror most AD vulnerable regions. Voxel-wise analysis also pointed to the same regions but lacked statistical power. In both cohorts, PICALM protective genotype AA only exhibited protective effects on hippocampal degeneration and cognitive performance when combined with CLU protective T allele, but adverse effects with CLU risk CC. This study revealed novel PICALM and CLU interaction effects on hippocampal degeneration along aging, and validated effectiveness of diffeomorphometry in imaging genetics study. (C) 2016 Wiley Periodicals, Inc.
关键词Picalm Clu Interaction Hippocampus Alzheimer's Disease
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1002/hbm.23183
关键词[WOS]ALZHEIMERS-DISEASE ; IN-VIVO ; BRAIN ; ASSOCIATION ; ENDOCYTOSIS ; INDIVIDUALS ; LOCI ; APOE ; METAANALYSIS ; REPLICATION
收录类别SCI
语种英语
项目资助者National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; National Natural Science Foundation of China(91132301) ; Alzheimer's Disease Neuroimaging Initiative (ADNI ; DOD ADNI (Department of Defense)(W81XWH-12-2-0012) ; National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering (ADNI) ; National Institutes of Health)(U01 AG024904)
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000382488800005
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10843
专题脑网络组研究中心
作者单位1.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
2.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld 4072, Australia
3.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Yang, Xianfeng,Li, Jin,Liu, Bing,et al. Impact of PICALM and CLU on Hippocampal Degeneration[J]. HUMAN BRAIN MAPPING,2016,37(7):2419-2430.
APA Yang, Xianfeng,Li, Jin,Liu, Bing,Li, Yonghui,&Jiang, Tianzi.(2016).Impact of PICALM and CLU on Hippocampal Degeneration.HUMAN BRAIN MAPPING,37(7),2419-2430.
MLA Yang, Xianfeng,et al."Impact of PICALM and CLU on Hippocampal Degeneration".HUMAN BRAIN MAPPING 37.7(2016):2419-2430.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Yangxf_HBM.pdf(470KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Xianfeng]的文章
[Li, Jin]的文章
[Liu, Bing]的文章
百度学术
百度学术中相似的文章
[Yang, Xianfeng]的文章
[Li, Jin]的文章
[Liu, Bing]的文章
必应学术
必应学术中相似的文章
[Yang, Xianfeng]的文章
[Li, Jin]的文章
[Liu, Bing]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Yangxf_HBM.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。