| Impact of PICALM and CLU on Hippocampal Degeneration | |
Yang, Xianfeng1,2; Li, Jin3,4,5 ; Liu, Bing3,4,5; Li, Yonghui1; Jiang, Tianzi1,2,3,4,5
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| 发表期刊 | HUMAN BRAIN MAPPING
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| 2016-07-01 | |
| 卷号 | 37期号:7页码:2419-2430 |
| 文章类型 | Article |
| 摘要 | PICALM and CLU are two major risk genes of late-onset Alzheimer's disease (LOAD), and there is strong molecular evidence suggesting their interaction on amyloid-beta deposition, hence finding functional dependency between their risk genotypes may lead to better understanding of their roles in LOAD development and greater clinical utility. In this study, we mainly investigated interaction effects of risk loci PICALM rs3581179 and CLU rs11136000 on hippocampal degeneration in both young and elderly adults in order to understand their neural mechanism on aging process, which may help identify robust biomarkers for early diagnosis and intervention. Besides volume we also assessed hippocampal shape phenotypes derived from diffeomorphic metric mapping and nonlinear dimensionality reduction. In elderly individuals (75.6 +/- 6.7 years) significant interaction effects existed on hippocampal volume (P < 0.001), whereas in young healthy adults (19.4 +/- 1.1 years) such effects existed on a shape phenotype (P = 0.01) indicating significant variation at hippocampal head and tail that mirror most AD vulnerable regions. Voxel-wise analysis also pointed to the same regions but lacked statistical power. In both cohorts, PICALM protective genotype AA only exhibited protective effects on hippocampal degeneration and cognitive performance when combined with CLU protective T allele, but adverse effects with CLU risk CC. This study revealed novel PICALM and CLU interaction effects on hippocampal degeneration along aging, and validated effectiveness of diffeomorphometry in imaging genetics study. (C) 2016 Wiley Periodicals, Inc. |
| 关键词 | Picalm Clu Interaction Hippocampus Alzheimer's Disease |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.1002/hbm.23183 |
| 关键词[WOS] | ALZHEIMERS-DISEASE ; IN-VIVO ; BRAIN ; ASSOCIATION ; ENDOCYTOSIS ; INDIVIDUALS ; LOCI ; APOE ; METAANALYSIS ; REPLICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; National Natural Science Foundation of China(91132301) ; Alzheimer's Disease Neuroimaging Initiative (ADNI ; DOD ADNI (Department of Defense)(W81XWH-12-2-0012) ; National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering (ADNI) ; National Institutes of Health)(U01 AG024904) |
| WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS记录号 | WOS:000382488800005 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/10843 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 作者单位 | 1.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 2.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld 4072, Australia 3.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xianfeng,Li, Jin,Liu, Bing,et al. Impact of PICALM and CLU on Hippocampal Degeneration[J]. HUMAN BRAIN MAPPING,2016,37(7):2419-2430. |
| APA | Yang, Xianfeng,Li, Jin,Liu, Bing,Li, Yonghui,&Jiang, Tianzi.(2016).Impact of PICALM and CLU on Hippocampal Degeneration.HUMAN BRAIN MAPPING,37(7),2419-2430. |
| MLA | Yang, Xianfeng,et al."Impact of PICALM and CLU on Hippocampal Degeneration".HUMAN BRAIN MAPPING 37.7(2016):2419-2430. |
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| Yangxf_HBM.pdf（470KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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