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Activation of mesenchymal stem cells by macrophages promotes tumor progression through immune suppressive effects
Jia, Xiao-hua1; Feng, Guo-wei2,4,5; Wang, Zhong-liang3; Du, Yang1; Shen, Chen1; Hui, Hui1; Peng, Dong1,3; Li, Zong-jin4; Kong, De-ling5; Tian, Jie1,6
2016-04-12
发表期刊ONCOTARGET
卷号7期号:15页码:20934-20944
文章类型Article
摘要Cancer development and progression is linked to tumor-associated macrophages (TAMs). Distinct TAMs subsets perform either protective or pathogenic effects in cancer. A protective role in carcinogenesis has been described for M1 macrophages, which activate antitumor mechanisms. By comparison, TAMs isolated from solid and metastatic tumors have a suppressive M2-like phenotype, which could support multiple aspects of tumor progression. Currently, it has not been clearly understood how macrophages in tumor-associated stroma could be hijacked to support tumor growth. Mesenchymal stem cells (MSCs) actively interact with components of the innate immune system and display both anti-inflammatory and pro-inflammatory effects. Here, we tested whether MSCs could favor the tumor to escape from immunologic surveillance in the presence of M1 macrophages. We found that MSCs educated by M1 condition medium (cMSCs) possessed a greatly enhanced ability in promoting tumor growth in vivo. Examination of cytokines/chemokines showed that the cMSCs acquired a regulatory profile, which expressed high levels of iNOS and MCP1. Consistent with an elevated MCP1 expression in cMSCs, the tumor-promoting effect of the cMSCs depended on MCP1 mediated macrophage recruitment to tumor sites. Furthermore, IL-6 secreted by the cMSCs could polarize infiltrated TAMs into M2-like macrophages. Therefore, when macrophages changed into M1 pro-inflammation type in tumor microenvironment, the MSCs would act as poor sensors and switchers to accelerate tumor growth.
关键词Mesenchymal Stem Cells Macrophages Inflammation Cancer Mcp1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ANTIINFLAMMATORY PROTEIN TSG-6 ; STROMAL CELLS ; CANCER ; INFLAMMATION ; PLASTICITY ; SUBSETS ; LUNG
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81301332 ; 81227901 ; 61231004 ; 81470083)
WOS研究方向Oncology ; Cell Biology
WOS类目Oncology ; Cell Biology
WOS记录号WOS:000375804000138
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10852
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Dept Genitourinary Oncol, Tianjin 300060, Peoples R China
3.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
4.Nankai Univ, Dept Pathophysiol, Sch Med, Tianjin 300071, Peoples R China
5.Nankai Univ, Coll Life Sci, Minist Educ, State Key Lab Med Chem Biol,Key Lab Bioact Mat, Tianjin 300071, Peoples R China
6.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
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Jia, Xiao-hua,Feng, Guo-wei,Wang, Zhong-liang,et al. Activation of mesenchymal stem cells by macrophages promotes tumor progression through immune suppressive effects[J]. ONCOTARGET,2016,7(15):20934-20944.
APA Jia, Xiao-hua.,Feng, Guo-wei.,Wang, Zhong-liang.,Du, Yang.,Shen, Chen.,...&Tian, Jie.(2016).Activation of mesenchymal stem cells by macrophages promotes tumor progression through immune suppressive effects.ONCOTARGET,7(15),20934-20944.
MLA Jia, Xiao-hua,et al."Activation of mesenchymal stem cells by macrophages promotes tumor progression through immune suppressive effects".ONCOTARGET 7.15(2016):20934-20944.
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