CASIA OpenIR  > 中国科学院分子影像重点实验室
Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation
Jin Z; Du Y; Schwaid AG; Asterholm IW; Scherer PE; Saghatelian A; Wan Y
2015-04
发表期刊Endocrinology
卷号156期号:4页码:1504-13
摘要Adiponectin is an important adipokine. Increasing evidence suggests that altered adiponectin levels are linked with metabolic and inflammatory disorders. Here we report an important yet previously unrecognized function of adiponectin in lactation by which maternaladiponectin determines the inflammatory status in the nursing neonates. Surprisingly, both maternal adiponectin overexpression in the transgenic mice and maternal adiponectin deletion in the knockout mice lead to systemic inflammation in the pups, manifested as transient hair loss. However, distinct mechanisms are involved. Adiponectin deficiency triggers leukocyte infiltration and production of inflammatory cytokines in the lactating mammary gland. In contrast, adiponectin overabundance increases lipid accumulation in the lactating mammary gland, resulting in excessive long-chain saturated fatty acids in milk. Interestingly, in both cases, the inflammation and alopecia in the pups can be rescued by Toll-like receptor (TLR)-2/4 deletion because TLR2/4 double-knockout pups are resistant. Mechanistically, long-chain saturated fatty acid activation of inflammatory genes is TLR2/4 dependent and can be potentiated by proinflammatory cytokines, indicating that the inflammatory stimuli in both scenarios functionally converge by activating the TLR2/4 signaling. Therefore, our findings reveal adiponectin as a dosage-dependent regulator of lactation homeostasis and milk quality that critically controls inflammation in the nursing neonates. Furthermore, these results suggest that inflammatory infantile disorders may result from maternal adiponectin dysregulation that can be treated by TLR2/4 inhibition.
关键词Adiponectin
DOI10.1210/en.2014-1738
收录类别SCI
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10866
专题中国科学院分子影像重点实验室
推荐引用方式
GB/T 7714
Jin Z,Du Y,Schwaid AG,et al. Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation[J]. Endocrinology,2015,156(4):1504-13.
APA Jin Z.,Du Y.,Schwaid AG.,Asterholm IW.,Scherer PE.,...&Wan Y.(2015).Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation.Endocrinology,156(4),1504-13.
MLA Jin Z,et al."Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation".Endocrinology 156.4(2015):1504-13.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jin Z]的文章
[Du Y]的文章
[Schwaid AG]的文章
百度学术
百度学术中相似的文章
[Jin Z]的文章
[Du Y]的文章
[Schwaid AG]的文章
必应学术
必应学术中相似的文章
[Jin Z]的文章
[Du Y]的文章
[Schwaid AG]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。