Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation

doi:10.1210/en.2014-1738

	Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation
	Jin Z; Du Y; Schwaid AG; Asterholm IW; Scherer PE; Saghatelian A; Wan Y
发表期刊	Endocrinology
	2015-04
卷号	156 期号:4 页码:1504-13
摘要	Adiponectin is an important adipokine. Increasing evidence suggests that altered adiponectin levels are linked with metabolic and inflammatory disorders. Here we report an important yet previously unrecognized function of adiponectin in lactation by which maternaladiponectin determines the inflammatory status in the nursing neonates. Surprisingly, both maternal adiponectin overexpression in the transgenic mice and maternal adiponectin deletion in the knockout mice lead to systemic inflammation in the pups, manifested as transient hair loss. However, distinct mechanisms are involved. Adiponectin deficiency triggers leukocyte infiltration and production of inflammatory cytokines in the lactating mammary gland. In contrast, adiponectin overabundance increases lipid accumulation in the lactating mammary gland, resulting in excessive long-chain saturated fatty acids in milk. Interestingly, in both cases, the inflammation and alopecia in the pups can be rescued by Toll-like receptor (TLR)-2/4 deletion because TLR2/4 double-knockout pups are resistant. Mechanistically, long-chain saturated fatty acid activation of inflammatory genes is TLR2/4 dependent and can be potentiated by proinflammatory cytokines, indicating that the inflammatory stimuli in both scenarios functionally converge by activating the TLR2/4 signaling. Therefore, our findings reveal adiponectin as a dosage-dependent regulator of lactation homeostasis and milk quality that critically controls inflammation in the nursing neonates. Furthermore, these results suggest that inflammatory infantile disorders may result from maternal adiponectin dysregulation that can be treated by TLR2/4 inhibition.
关键词	Adiponectin
DOI	10.1210/en.2014-1738
收录类别	SCI
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/10866
专题	中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Jin Z,Du Y,Schwaid AG,et al. Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation[J]. Endocrinology,2015,156(4):1504-13.
APA	Jin Z.,Du Y.,Schwaid AG.,Asterholm IW.,Scherer PE.,...&Wan Y.(2015).Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation.Endocrinology,156(4),1504-13.
MLA	Jin Z,et al."Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation".Endocrinology 156.4(2015):1504-13.