CASIA OpenIR  > 中国科学院分子影像重点实验室
Effect of surface properties on liposomal siRNA delivery
Xia, Yuqiong1; Tian, Jie1,2; Chen, Xiaoyuan3
Source PublicationBIOMATERIALS
2016-02-01
Volume79Issue:2015Pages:56-68
SubtypeReview
AbstractLiposomes are one of the most widely investigated carriers for siRNA delivery. The surface properties of liposomal carriers, including the surface charge, PEGylation, and ligand modification can significantly affect the gene silencing efficiency. Three barriers of systemic siRNA delivery (long blood circulation, efficient tumor penetration and efficient cellular uptake/endosomal escape) are analyzed on liposomal carriers with different surface charges, PEGylations and ligand modifications. Cationic formulations dominate siRNA delivery and neutral formulations also have good performance while anionic formulations are generally not proper for siRNA delivery. The PEG dilemma (prolonged blood circulation vs. reduced cellular uptake/endosomal escape) and the side effect of repeated PEGylated formulation (accelerated blood clearance) were discussed. Effects of ligand modification on cationic and neutral formulations were analyzed. Finally, we summarized the achievements in liposomal siRNA delivery, outlined existing problems and provided some future perspectives. Published by Elsevier Ltd.
KeywordSirna Delivery Liposomes Surface Charge Pegylation Ligand Modification
WOS HeadingsScience & Technology ; Technology
DOI10.1016/j.biomaterials.2015.11.056
WOS KeywordSMALL INTERFERING RNA ; ACCELERATED BLOOD CLEARANCE ; CALCIUM-PHOSPHATE NANOPARTICLES ; LIPID-LIKE MATERIALS ; PEG IGM PRODUCTION ; IN-VIVO ; GENE DELIVERY ; CANCER-CELLS ; POLY(ETHYLENE GLYCOL) ; CATIONIC LIPOSOMES
Indexed BySCI
Language英语
Funding Organizationprogram of China Scholarships Council(1408260074) ; Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000368868400006
Citation statistics
Cited Times:54[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/11336
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
3.NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
Recommended Citation
GB/T 7714
Xia, Yuqiong,Tian, Jie,Chen, Xiaoyuan. Effect of surface properties on liposomal siRNA delivery[J]. BIOMATERIALS,2016,79(2015):56-68.
APA Xia, Yuqiong,Tian, Jie,&Chen, Xiaoyuan.(2016).Effect of surface properties on liposomal siRNA delivery.BIOMATERIALS,79(2015),56-68.
MLA Xia, Yuqiong,et al."Effect of surface properties on liposomal siRNA delivery".BIOMATERIALS 79.2015(2016):56-68.
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