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Effect of surface properties on liposomal siRNA delivery
Xia, Yuqiong1; Tian, Jie1,2; Chen, Xiaoyuan3
2016-02-01
发表期刊BIOMATERIALS
卷号79期号:2015页码:56-68
文章类型Review
摘要Liposomes are one of the most widely investigated carriers for siRNA delivery. The surface properties of liposomal carriers, including the surface charge, PEGylation, and ligand modification can significantly affect the gene silencing efficiency. Three barriers of systemic siRNA delivery (long blood circulation, efficient tumor penetration and efficient cellular uptake/endosomal escape) are analyzed on liposomal carriers with different surface charges, PEGylations and ligand modifications. Cationic formulations dominate siRNA delivery and neutral formulations also have good performance while anionic formulations are generally not proper for siRNA delivery. The PEG dilemma (prolonged blood circulation vs. reduced cellular uptake/endosomal escape) and the side effect of repeated PEGylated formulation (accelerated blood clearance) were discussed. Effects of ligand modification on cationic and neutral formulations were analyzed. Finally, we summarized the achievements in liposomal siRNA delivery, outlined existing problems and provided some future perspectives. Published by Elsevier Ltd.
关键词Sirna Delivery Liposomes Surface Charge Pegylation Ligand Modification
WOS标题词Science & Technology ; Technology
DOI10.1016/j.biomaterials.2015.11.056
关键词[WOS]SMALL INTERFERING RNA ; ACCELERATED BLOOD CLEARANCE ; CALCIUM-PHOSPHATE NANOPARTICLES ; LIPID-LIKE MATERIALS ; PEG IGM PRODUCTION ; IN-VIVO ; GENE DELIVERY ; CANCER-CELLS ; POLY(ETHYLENE GLYCOL) ; CATIONIC LIPOSOMES
收录类别SCI
语种英语
项目资助者program of China Scholarships Council(1408260074) ; Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
WOS研究方向Engineering ; Materials Science
WOS类目Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号WOS:000368868400006
引用统计
被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/11336
专题中国科学院分子影像重点实验室
通讯作者Tian, Jie
作者单位1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
3.NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
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Xia, Yuqiong,Tian, Jie,Chen, Xiaoyuan. Effect of surface properties on liposomal siRNA delivery[J]. BIOMATERIALS,2016,79(2015):56-68.
APA Xia, Yuqiong,Tian, Jie,&Chen, Xiaoyuan.(2016).Effect of surface properties on liposomal siRNA delivery.BIOMATERIALS,79(2015),56-68.
MLA Xia, Yuqiong,et al."Effect of surface properties on liposomal siRNA delivery".BIOMATERIALS 79.2015(2016):56-68.
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