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Intraoperative Identification of Liver Cancer Microfoci Using a Targeted Near-Infrared Fluorescent Probe for Imaging-Guided Surgery
Zeng, Chaoting1,2; Shang, Wenting2,3; Wang, Kun2,3; Chi, Chongwei2,3; Jia, Xiaohua2,3; Fang, Cheng1; Yang, Du2,3; Ye, Jinzuo2; Fang, Chihua1; Tian, Jie2,3
2016-02-29
发表期刊SCIENTIFIC REPORTS
卷号6期号:2016页码:-
文章类型Article
摘要Difficulties in the highly sensitive detection of tumour microfoci represent a critical obstacle toward improved surgical intervention in liver cancer. Conventional preoperative imaging methods and surgeons' subjective experience are limited by their inability to effectively detect tumour lesions measuring less than 2 mm; however, intraoperative fluorescence molecular imaging may overcome this limitation. Here, we synthesised an arginine-glycine-aspartic acid (RGD)-conjugated mesoporous silica nanoparticle (MSN) highly loaded with indocyanine green (ICG) dye that could accurately delineate liver cancer margins and provide excellent tumour-to-normal tissue contrast intraoperatively. The increased ICG loading capacity and tumour specificity enabled the identification of residual microtumours and satellite lesions measuring less than 1 mm in living mice. Histological analysis validated the sensitivity and accuracy of this approach. We believe this technique utilising a new fluorescent nanoprobe with intraoperative optical imaging may offer a more sensitive and accurate method for liver cancer resection guidance, resulting in better surgical outcomes.
关键词Liver Cancer Targeted Near-infrared
WOS标题词Science & Technology
DOI10.1038/srep21959
关键词[WOS]METASTATIC BREAST-CANCER ; MESOPOROUS SILICA NANOPARTICLES ; INDOCYANINE GREEN ; HEPATOCELLULAR-CARCINOMA ; INTEGRIN ALPHA(V)BETA(3) ; SURGICAL GUIDANCE ; DOSE-ESCALATION ; DRUG-DELIVERY ; SENTINEL NODE ; NAVIGATION
收录类别SCI
语种英语
项目资助者National Basic Research Program of China (973 Program)(2015CB755500) ; National Natural Science Foundation of China(81227901 ; National High Technology Research and Development Program of China (863 Program)(2012AA021105) ; 61231004 ; U1401254 ; 61401462 ; 61501462 ; 81527805 ; 81470083)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000371107200001
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被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/11353
专题中国科学院分子影像重点实验室
通讯作者Tian, Jie
作者单位1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
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Zeng, Chaoting,Shang, Wenting,Wang, Kun,et al. Intraoperative Identification of Liver Cancer Microfoci Using a Targeted Near-Infrared Fluorescent Probe for Imaging-Guided Surgery[J]. SCIENTIFIC REPORTS,2016,6(2016):-.
APA Zeng, Chaoting.,Shang, Wenting.,Wang, Kun.,Chi, Chongwei.,Jia, Xiaohua.,...&Tian, Jie.(2016).Intraoperative Identification of Liver Cancer Microfoci Using a Targeted Near-Infrared Fluorescent Probe for Imaging-Guided Surgery.SCIENTIFIC REPORTS,6(2016),-.
MLA Zeng, Chaoting,et al."Intraoperative Identification of Liver Cancer Microfoci Using a Targeted Near-Infrared Fluorescent Probe for Imaging-Guided Surgery".SCIENTIFIC REPORTS 6.2016(2016):-.
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