CASIA OpenIR  > 脑网络组研究中心
Towards higher sensitivity and stability of axon diameter estimation with diffusion-weighted MRI
Sepehrband, Farshid1,2; Alexander, Daniel C.3; Kurniawan, Nyoman D.1; Reutens, David C.1,4; Yang, Zhengyi1,5,6,7
Source PublicationNMR IN BIOMEDICINE
2016-03-01
Volume29Issue:3Pages:293-308
SubtypeArticle
AbstractDiffusion-weighted MRI is an important tool for in vivo and non-invasive axon morphometry. The ActiveAx technique utilises an optimised acquisition protocol to infer orientationally invariant indices of axon diameter and density by fitting a model of white matter to the acquired data. In this study, we investigated the factors that influence the sensitivity to small-diameter axons, namely the gradient strength of the acquisition protocol and the model fitting routine. Diffusion-weighted ex. vivo images of the mouse brain were acquired using 16.4-T MRI with high (G(max) of 300 mT/m) and ultra-high (G(max) of 1350 mT/m) gradient strength acquisitions. The estimated axon diameter indices of the mid-sagittal corpus callosum were validated using electron microscopy. In addition, a dictionary-based fitting routine was employed and evaluated. Axon diameter indices were closer to electron microscopy measures when higher gradient strengths were employed. Despite the improvement, estimated axon diameter indices (a lower bound of similar to 1.8m) remained higher than the measurements obtained using electron microscopy (similar to 1.2m). We further observed that limitations of pulsed gradient spin echo (PGSE) acquisition sequences and axonal dispersion could also influence the sensitivity with which axon diameter indices could be estimated. Our results highlight the influence of acquisition protocol, tissue model and model fitting, in addition to gradient strength, on advanced microstructural diffusion-weighted imaging techniques. (c) 2016 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.
KeywordDiffusion-weighted Mri Activeax Ultra-high Gradient Strength Axon Diameter Index Histological Validation Electron Microscopy Mouse Corpus Callosum
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Technology
DOI10.1002/nbm.3462
WOS KeywordCOMPARTMENT MODELS ; CORPUS-CALLOSUM ; WHITE-MATTER ; SPIN-ECHO ; RESTRICTED DIFFUSION ; SELF-DIFFUSION ; MOUSE-BRAIN ; 300 MT/M ; MICROSTRUCTURE ; NMR
Indexed BySCI
Language英语
Funding OrganizationUniversity of Queensland Centennial (UQCent) ; International Postgraduate Research Scholarship (IPRS) ; National Health and Medical Research Council of Australia(628952) ; EPSRC(G007748 I027084 L022680 ; M020533)
WOS Research AreaBiophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS SubjectBiophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS IDWOS:000371426000010
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/11362
Collection脑网络组研究中心
Affiliation1.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld 4072, Australia
2.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
3.UCL, Dept Comp Sci, London, England
4.UCL, Ctr Med Image Comp, London, England
5.Univ Queensland, Sch Informat Technol & Elect Engn, Brisbane, Qld, Australia
6.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China
7.Southwest Univ Sci & Technol, Fac Informat Engn, Mianyang, Peoples R China
Recommended Citation
GB/T 7714
Sepehrband, Farshid,Alexander, Daniel C.,Kurniawan, Nyoman D.,et al. Towards higher sensitivity and stability of axon diameter estimation with diffusion-weighted MRI[J]. NMR IN BIOMEDICINE,2016,29(3):293-308.
APA Sepehrband, Farshid,Alexander, Daniel C.,Kurniawan, Nyoman D.,Reutens, David C.,&Yang, Zhengyi.(2016).Towards higher sensitivity and stability of axon diameter estimation with diffusion-weighted MRI.NMR IN BIOMEDICINE,29(3),293-308.
MLA Sepehrband, Farshid,et al."Towards higher sensitivity and stability of axon diameter estimation with diffusion-weighted MRI".NMR IN BIOMEDICINE 29.3(2016):293-308.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Sepehrband, Farshid]'s Articles
[Alexander, Daniel C.]'s Articles
[Kurniawan, Nyoman D.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Sepehrband, Farshid]'s Articles
[Alexander, Daniel C.]'s Articles
[Kurniawan, Nyoman D.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Sepehrband, Farshid]'s Articles
[Alexander, Daniel C.]'s Articles
[Kurniawan, Nyoman D.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.