Towards higher sensitivity and stability of axon diameter estimation with diffusion-weighted MRI

doi:10.1002/nbm.3462

	Towards higher sensitivity and stability of axon diameter estimation with diffusion-weighted MRI
	Sepehrband, Farshid 1,2; Alexander, Daniel C.3; Kurniawan, Nyoman D.1; Reutens, David C.1,4; Yang, Zhengyi1,5,6,7
发表期刊	NMR IN BIOMEDICINE
	2016-03-01
卷号	29 期号:3 页码:293-308
文章类型	Article
摘要	Diffusion-weighted MRI is an important tool for in vivo and non-invasive axon morphometry. The ActiveAx technique utilises an optimised acquisition protocol to infer orientationally invariant indices of axon diameter and density by fitting a model of white matter to the acquired data. In this study, we investigated the factors that influence the sensitivity to small-diameter axons, namely the gradient strength of the acquisition protocol and the model fitting routine. Diffusion-weighted ex. vivo images of the mouse brain were acquired using 16.4-T MRI with high (G(max) of 300 mT/m) and ultra-high (G(max) of 1350 mT/m) gradient strength acquisitions. The estimated axon diameter indices of the mid-sagittal corpus callosum were validated using electron microscopy. In addition, a dictionary-based fitting routine was employed and evaluated. Axon diameter indices were closer to electron microscopy measures when higher gradient strengths were employed. Despite the improvement, estimated axon diameter indices (a lower bound of similar to 1.8m) remained higher than the measurements obtained using electron microscopy (similar to 1.2m). We further observed that limitations of pulsed gradient spin echo (PGSE) acquisition sequences and axonal dispersion could also influence the sensitivity with which axon diameter indices could be estimated. Our results highlight the influence of acquisition protocol, tissue model and model fitting, in addition to gradient strength, on advanced microstructural diffusion-weighted imaging techniques. (c) 2016 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.
关键词	Diffusion-weighted Mri Activeax Ultra-high Gradient Strength Axon Diameter Index Histological Validation Electron Microscopy Mouse Corpus Callosum
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Technology
DOI	10.1002/nbm.3462
关键词[WOS]	COMPARTMENT MODELS ; CORPUS-CALLOSUM ; WHITE-MATTER ; SPIN-ECHO ; RESTRICTED DIFFUSION ; SELF-DIFFUSION ; MOUSE-BRAIN ; 300 MT/M ; MICROSTRUCTURE ; NMR
收录类别	SCI
语种	英语
项目资助者	University of Queensland Centennial (UQCent) ; International Postgraduate Research Scholarship (IPRS) ; National Health and Medical Research Council of Australia(628952) ; EPSRC(G007748 I027084 L022680 ; M020533)
WOS研究方向	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS类目	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS记录号	WOS:000371426000010
引用统计	被引频次：49[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/11362
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld 4072, Australia 2.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia 3.UCL, Dept Comp Sci, London, England 4.UCL, Ctr Med Image Comp, London, England 5.Univ Queensland, Sch Informat Technol & Elect Engn, Brisbane, Qld, Australia 6.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 7.Southwest Univ Sci & Technol, Fac Informat Engn, Mianyang, Peoples R China
推荐引用方式 GB/T 7714	Sepehrband, Farshid,Alexander, Daniel C.,Kurniawan, Nyoman D.,et al. Towards higher sensitivity and stability of axon diameter estimation with diffusion-weighted MRI[J]. NMR IN BIOMEDICINE,2016,29(3):293-308.
APA	Sepehrband, Farshid,Alexander, Daniel C.,Kurniawan, Nyoman D.,Reutens, David C.,&Yang, Zhengyi.(2016).Towards higher sensitivity and stability of axon diameter estimation with diffusion-weighted MRI.NMR IN BIOMEDICINE,29(3),293-308.
MLA	Sepehrband, Farshid,et al."Towards higher sensitivity and stability of axon diameter estimation with diffusion-weighted MRI".NMR IN BIOMEDICINE 29.3(2016):293-308.