Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer | |
Zhang, Qian1,2,3 ; Du, Yang3; Jing, Lijia4; Liang, Xiaolong5; Li, Yaqian3,6; Li, Xiaofeng7,8; Dai, Zhifei5; Tian, Jie1,2,3
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| 发表期刊 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
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| 2016-03-01 | |
| 卷号 | 12期号:3页码:491-502 |
| 文章类型 | Article |
| 摘要 | Endostar, a novel recombinant human endostatin, has been proven to inhibit tumor angiogenesis and is utilized as an anticancer drug. While free drugs can display limited efficacy, nanoscaled anticancer drugs have been fabricated and proven to possess superior therapeutic effects. Poly(lactic acid) (PLA) is a FDA-approved biomaterial displaying excellent biocompatibility and low toxicity. In this study, Endostar-loaded PLA nanoparticles (EPNPs) were first prepared, and a near-infrared (NIR) dye, IRDye 800CW, was conjugated to the surface for detecting nanoparticle biodistribution through fluorescence molecular imaging (FMI) using an orthotopic breast tumor mouse model. The antitumor efficacy of EPNPs was examined using bioluminescence imaging (BLI) and immunohistology. To further improve the antitumor effects, we combined EPNPs with zoledronic acid monohydrate (ZA), which is known to decrease the tumor-associated macrophages (TAM) and inhibit tumor progression. We found that EPNPs decreased human umbilical vein endothelial cell (HUVEC) viability by inhibiting tumor growth gene expression more significantly than free Endostar in vitro. In vivo, EPNPs displayed better tumor growth inhibitory effects compared with free Endostar, and the combination of EPNPs with ZA exhibited more significant antitumor effects. As confirmed by CD31 and CD11b immunohistochemistry, the combination of EPNPs and ZA showed synergistic effects in reducing tumor angiogenesis and TAM accumulation in tumor regions. Taken together, this study presents a novel and effective form of nanoscaled Endostar for the treatment of breast cancer that displays synergistic antitumor effects in combination with ZA. |
| 关键词 | Endostar Poly Lactic Acid (Pla) Zoledronic Acid (Za) Breast Cancer Nanoparticle Molecular Imaging |
| WOS标题词 | Science & Technology ; Technology |
| DOI | 10.1166/jbn.2016.2022 |
| 关键词[WOS] | TUMOR-ASSOCIATED MACROPHAGES ; RECOMBINANT HUMAN ENDOSTATIN ; BIODEGRADABLE NANOPARTICLES ; DRUG-DELIVERY ; PROGRESSION ; METASTASIS ; THERAPY ; PHARMACOKINETICS ; ANGIOGENESIS ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | Program of the National Basic Research and Development Program of China (973)(2011CB707702 ; National Natural Science Foundation of China(81090272 ; National Key Technology Support Program(2012BAI23B06) ; State Key laboratory of Management and Control for Complex Systems(Y3S9021F30) ; 2014CB748600) ; 81227901) |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Biomaterials |
| WOS记录号 | WOS:000371451000007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/11363 |
| 专题 | 中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China 5.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China 6.Harbin Univ Sci & Technol, Harbin 150080, Peoples R China 7.Univ Louisville, Sch Med, Dept Diagnost Radiol, Louisville, KY 40208 USA 8.Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10065 USA |
| 第一作者单位 | 中国科学院自动化研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Qian,Du, Yang,Jing, Lijia,et al. Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2016,12(3):491-502. |
| APA | Zhang, Qian.,Du, Yang.,Jing, Lijia.,Liang, Xiaolong.,Li, Yaqian.,...&Tian, Jie.(2016).Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,12(3),491-502. |
| MLA | Zhang, Qian,et al."Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 12.3(2016):491-502. |
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| Infra Red Dye and En（5902KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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