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Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer
Zhang, Qian1,2,3; Du, Yang3; Jing, Lijia4; Liang, Xiaolong5; Li, Yaqian3,6; Li, Xiaofeng7,8; Dai, Zhifei5; Tian, Jie1,2,3
Source PublicationJOURNAL OF BIOMEDICAL NANOTECHNOLOGY
2016-03-01
Volume12Issue:3Pages:491-502
SubtypeArticle
AbstractEndostar, a novel recombinant human endostatin, has been proven to inhibit tumor angiogenesis and is utilized as an anticancer drug. While free drugs can display limited efficacy, nanoscaled anticancer drugs have been fabricated and proven to possess superior therapeutic effects. Poly(lactic acid) (PLA) is a FDA-approved biomaterial displaying excellent biocompatibility and low toxicity. In this study, Endostar-loaded PLA nanoparticles (EPNPs) were first prepared, and a near-infrared (NIR) dye, IRDye 800CW, was conjugated to the surface for detecting nanoparticle biodistribution through fluorescence molecular imaging (FMI) using an orthotopic breast tumor mouse model. The antitumor efficacy of EPNPs was examined using bioluminescence imaging (BLI) and immunohistology. To further improve the antitumor effects, we combined EPNPs with zoledronic acid monohydrate (ZA), which is known to decrease the tumor-associated macrophages (TAM) and inhibit tumor progression. We found that EPNPs decreased human umbilical vein endothelial cell (HUVEC) viability by inhibiting tumor growth gene expression more significantly than free Endostar in vitro. In vivo, EPNPs displayed better tumor growth inhibitory effects compared with free Endostar, and the combination of EPNPs with ZA exhibited more significant antitumor effects. As confirmed by CD31 and CD11b immunohistochemistry, the combination of EPNPs and ZA showed synergistic effects in reducing tumor angiogenesis and TAM accumulation in tumor regions. Taken together, this study presents a novel and effective form of nanoscaled Endostar for the treatment of breast cancer that displays synergistic antitumor effects in combination with ZA.
KeywordEndostar Poly Lactic Acid (Pla) Zoledronic Acid (Za) Breast Cancer Nanoparticle Molecular Imaging
WOS HeadingsScience & Technology ; Technology
DOI10.1166/jbn.2016.2022
WOS KeywordTUMOR-ASSOCIATED MACROPHAGES ; RECOMBINANT HUMAN ENDOSTATIN ; BIODEGRADABLE NANOPARTICLES ; DRUG-DELIVERY ; PROGRESSION ; METASTASIS ; THERAPY ; PHARMACOKINETICS ; ANGIOGENESIS ; CELLS
Indexed BySCI
Language英语
Funding OrganizationProgram of the National Basic Research and Development Program of China (973)(2011CB707702 ; National Natural Science Foundation of China(81090272 ; National Key Technology Support Program(2012BAI23B06) ; State Key laboratory of Management and Control for Complex Systems(Y3S9021F30) ; 2014CB748600) ; 81227901)
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS IDWOS:000371451000007
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/11363
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China
5.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
6.Harbin Univ Sci & Technol, Harbin 150080, Peoples R China
7.Univ Louisville, Sch Med, Dept Diagnost Radiol, Louisville, KY 40208 USA
8.Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10065 USA
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Qian,Du, Yang,Jing, Lijia,et al. Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2016,12(3):491-502.
APA Zhang, Qian.,Du, Yang.,Jing, Lijia.,Liang, Xiaolong.,Li, Yaqian.,...&Tian, Jie.(2016).Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,12(3),491-502.
MLA Zhang, Qian,et al."Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 12.3(2016):491-502.
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