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Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study
Tang, Zhenchao1; Dong, Enqing1; Liu, Jiaojiao2; Liu, Zhenyu3; Wei, Wenjuan3; Wang, Bo4; Li, Hongjun2; Tian, Jie3
2016-04-01
发表期刊JOURNAL OF NEUROVIROLOGY
卷号22期号:2页码:231-239
文章类型Article
摘要Previous diffusion tensor imaging (DTI) studies found that human immunodeficiency virus (HIV) infection led to white matter (WM) microstructure degeneration. Most of the DTI studies were cross-sectional and thus merely investigated only one specific point in the disease. In order to systematically study the WM impairments caused by HIV infection, more longitudinal studies are needed. However, longitudinal studies on HIV patients are very difficult to conduct. To address this question, we employed the simian immunodeficiency virus (SIV)-infected rhesus monkeys model to carry out a longitudinal DTI study. We aimed to longitudinally access the WM abnormalities of SIV-infected rhesus monkeys by studying the fractional anisotropy (FA) alterations with Tract Based Spatial Statistic (TBSS) analysis. Four rhesus monkeys inoculated intravenously with SIVmac239 were utilized in the study. DTI scans and peripheral blood CD4(+) and CD8(+) T cell counts were acquired prior to virus inoculation (as the baseline) and in the 12th and 24th week postvirus inoculation. Significant FA alterations were found in the two areas of the inferotemporal regions (iTE), respectively located in the ventral subregion of posterior iTE (iTEpv) and the dorsal subregion of iTE (iTEpd). The decreased FA values in iTEpd were found significantly negatively correlated with the elevated peripheral blood CD4(+)/CD8(+) ratios. It might suggest that WM in iTEpd was still impaired even though the immune dysfunction alleviated temporally.
关键词Simian Immunodeficiency Virus Longitudinal Study Diffusion Tensor Imaging Fractional Anisotropy Tract-based Spatial Statistic
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1007/s13365-015-0388-1
关键词[WOS]WHITE-MATTER INTEGRITY ; T-CELL-ACTIVATION ; ANTIRETROVIRAL THERAPY ; HIV-INFECTION ; CORPUS-CALLOSUM ; NEUROCOGNITIVE DISORDERS ; SPATIAL STATISTICS ; NEURAL FRAMEWORK ; RHESUS-MONKEYS ; SIV INFECTION
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology ; Virology
WOS类目Neurosciences ; Virology
WOS记录号WOS:000371929900011
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/11369
专题中国科学院分子影像重点实验室
通讯作者Tian, Jie
作者单位1.Shandong Univ, Sch Mech Elect & Informat Engn, Weihai 264209, Shandong, Peoples R China
2.Capital Med Univ, Beijing YouAn Hosp, Beijing 100069, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Harbin Univ Sci & Technol, Sch Automat, Harbin 150080, Peoples R China
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GB/T 7714
Tang, Zhenchao,Dong, Enqing,Liu, Jiaojiao,et al. Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study[J]. JOURNAL OF NEUROVIROLOGY,2016,22(2):231-239.
APA Tang, Zhenchao.,Dong, Enqing.,Liu, Jiaojiao.,Liu, Zhenyu.,Wei, Wenjuan.,...&Tian, Jie.(2016).Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study.JOURNAL OF NEUROVIROLOGY,22(2),231-239.
MLA Tang, Zhenchao,et al."Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study".JOURNAL OF NEUROVIROLOGY 22.2(2016):231-239.
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