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Disrupted effective connectivity of the sensorimotor network in amyotrophic lateral sclerosis
Fang, Xiaojing1; Zhang, Yuanchao1; Wang, Yue1; Zhang, Yuling1; Hu, Jun2; Wang, Jian3; Zhang, Jiuquan3; Jiang, Tianzi1,4,5,6,7
Source PublicationJOURNAL OF NEUROLOGY
2016-03-01
Volume263Issue:3Pages:508-516
SubtypeArticle
AbstractAlthough dysfunctional sensorimotor network (SMN) has been frequently involved in the pathogenesis of amyotrophic lateral sclerosis (ALS), the causal relationship within this network remains unexplored. In this study, spectral dynamic causal modeling was applied to resting-state functional magnetic resonance imaging data to estimate the causal relationship of SMN in a cohort of 20 ALS patients and 21 healthy controls. The SMN components were first extracted using an independent component analysis, and then compared between the two groups to identify the abnormalities in SMN. In ALS patients, we found significant regional activity alterations in the left primary motor cortex (M1), the left primary somatosensory cortex (S1), and the right supplementary motor cortex (SMA). Among these regions, spectral DCM revealed missing closed-loop circuit between the left M1 and the right SMA, and lost projection from the right SMA to the left S1 in ALS. These findings may reflect the influences of the loss of motor neurons on motor function in ALS, and provide compelling evidence for a breakdown of the sensorimotor neural circuits in ALS. In conclusion, this study elucidates a neurobiological model that may explain the functional impairments of the SMN in ALS, and provides much deeper insights into the pathophysiology of this disease.
KeywordAmyotrophic Lateral Sclerosis Effective Connectivity Resting-state Fmri Spectral Dynamic Causal Modeling Sensorimotor Network
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s00415-015-8013-z
WOS KeywordSUPPLEMENTARY MOTOR AREA ; FUNCTIONAL CONNECTIVITY ; CORTICAL ACTIVATION ; ALZHEIMERS-DISEASE ; NEURONAL INTEGRITY ; GRANGER CAUSALITY ; CORTEX ; IMAGERY ; INHIBITION ; HANDEDNESS
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81101000 ; Science and Technology Department of Sichuan Province(2014SZ0014 ; 81200882) ; 2013SZ0033)
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology
WOS IDWOS:000372433600014
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/11379
Collection脑网络组研究中心
Affiliation1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
2.Third Mil Med Univ, Southwest Hosp, Dept Neurol, Chongqing 400038, Peoples R China
3.Third Mil Med Univ, Southwest Hosp, Dept Radiol, Chongqing 400038, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing, Peoples R China
7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
Recommended Citation
GB/T 7714
Fang, Xiaojing,Zhang, Yuanchao,Wang, Yue,et al. Disrupted effective connectivity of the sensorimotor network in amyotrophic lateral sclerosis[J]. JOURNAL OF NEUROLOGY,2016,263(3):508-516.
APA Fang, Xiaojing.,Zhang, Yuanchao.,Wang, Yue.,Zhang, Yuling.,Hu, Jun.,...&Jiang, Tianzi.(2016).Disrupted effective connectivity of the sensorimotor network in amyotrophic lateral sclerosis.JOURNAL OF NEUROLOGY,263(3),508-516.
MLA Fang, Xiaojing,et al."Disrupted effective connectivity of the sensorimotor network in amyotrophic lateral sclerosis".JOURNAL OF NEUROLOGY 263.3(2016):508-516.
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