综合信息系统研究中心知识库

In  this  paper,  some  proteins  were  determined  as  potential  drug  targets  for  H1N1  influenza  A.  These proteins were found using  three steps: i)  determining a set of human proteins that  had interactions with the  proteins  of  H1N1  virus,  and  assigning  a  weight  to  each  protein;  ii)  mapping  the  set  of  human proteins into the human protein-protein interaction networks; iii) combining  the topological properties of the network and the weights of the proteins to determine the score of each node.  Eventually , TRAF2 

and  MAPK9,  two  nodes  with  high  scores,  were  regarded  as  potential  drug  targets.  The  results  were consistent  when  different  databases  were  used,  and  were  in  agreement  with  the  KEGG  pathways  to some degree. However, it still needs further study  to ascertain  whether these potential targets can be novel practical targets applied in the drug design.