CASIA OpenIR  > 综合信息系统研究中心
陈迪1; 卢朋1,2; 张方博2; 唐仕欢2; 杨洪军2; 卢朋,杨洪军
Source Publication中国中药杂志
; Objective:The theory of treating heart and brain simultaneously is from the theory of traditional Chinese medicine, and there aren’t enough explanations for this theory from the perspective of molecular mechanism.As one successful case of this theory, the Chinese medicine formula——BuchaIlg Naoxintong can achieve the goal of treating coronary heart disease and stroke at the same time.To illustrate the mechanism of the theory of treating heart and brain simultaneously,it is necessary to find out the molecular mechanism of this formula.Method:Using the network analysis method,together with two data mining methods-clustering and apriori algorithm,the frequent gene combinations interfered by the chemicals of the formula based on the protein—protein interaction networks relat— ed with coronary heart disease and stroke disease were figured out respectively.To find out the molecular mechanism of the theory of treating heart and brain simultaneously, the results got from two diseases were compared and analyzed Result:Based on comparing two results from these two different diseases,the mechanism of the theory of treating heart and brain simultaneously was explained from molecular level by finding out key genes targeted by the components of this formula for both diseases and some particular genes interfered by the components for each disease.In addition, genes interfered indirectly by the chemicals for different diseases were found out based on the protein-protein interaction network.Conclusion:It can help to explain the molecular mechanism of the theory by Oily methods. By finding out the molecular mechanism of this theory,it can promote the progress of combination of Chinese traditional and Western medicine.
Keyword网络分析 数据挖掘 脑心同治 步长脑心通方 分子作用机制
Document Type期刊论文
Corresponding Author卢朋,杨洪军
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
陈迪,卢朋,张方博,等. 基于数据挖掘和网络分析的“脑心同治”分子机制研究[J]. 中国中药杂志,2013,38(1):62-69.
APA 陈迪,卢朋,张方博,唐仕欢,杨洪军,&卢朋,杨洪军.(2013).基于数据挖掘和网络分析的“脑心同治”分子机制研究.中国中药杂志,38(1),62-69.
MLA 陈迪,et al."基于数据挖掘和网络分析的“脑心同治”分子机制研究".中国中药杂志 38.1(2013):62-69.
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