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In vivo three-dimensional radiopharmaceutical excited fluorescence tomography(已录用,待发表)
Zhenhua Hu; Mingxuan Zhao; Yawei Qu; Xiaojun Zhang; Mingru Zhang; Muhan Liu; Hongbo Guo; Zeyu Zhang; Jing Wang; Weidong Yang; Jie Tian
2016
发表期刊Journal of Nuclear Medicine
期号-页码:-
其他摘要
Cerenkov luminescence imaging (CLI) can image radiopharmaceuticals using
high-sensitivity charge coupled device (CCD) camera. However, Cerenkov
luminescence (CL) emitted from the radiopharmaceuticals is weak and has low
penetration depth in biological tissues, which severely limits the sensitivity and
accuracy of CLI. This study presents the three-dimensional (3D) radiopharmaceutical
excited fluorescence tomography (REFT) using europium oxide (EO) nanoparticles,
which enhances the CL signal intensity, improves the penetration depth, and obtains
more accurate 3D distribution of radiopharmaceuticals. Methods: The enhanced
optical signals of various radiopharmaceuticals (including Na 131 I,
18 F-FDG, 68 GaCl 3 ,
Na 99m TcO 4 ) by EO nanoparticles were detected in vitro. The location and 3D
distribution of the radiopharmaceuticals of REFT were then reconstructed and
compared with those of Cerenkov luminescence tomography (CLT) through the
experiments of the phantom, artificial source-implanted mouse models, and mice
bearing hepatocellular carcinomas (HCCs). Results: The mixture of  68 GaCl 3 and EO
nanoparticles possessed the strongest optical signals compared with the other mixtures.
The in vitro phantom and implanted mouse studies showed that REFT revealed more
accurate 3D distribution of
68 GaCl 3 . REFT can detected more tumors than small
animal positron emission tomography (PET) in HCC bearing mice and achieved more
accurate 3D distribution information compared with CLT. Conclusion: REFT with
EO  nanoparticles  significantly  improves  accuracy  of  localization  of
radiopharmaceuticals and can precisely localize the tumor in vivo.
关键词Radiopharmaceutical Excitation Fluorescence Tomography (Reft) Cerenkov Luminescence Imaging (Cli) Radionuclides Hepatocellular Carcinoma (Hcc) Pet
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/11998
专题中国科学院分子影像重点实验室
通讯作者Jing Wang
推荐引用方式
GB/T 7714
Zhenhua Hu,Mingxuan Zhao,Yawei Qu,等. In vivo three-dimensional radiopharmaceutical excited fluorescence tomography(已录用,待发表)[J]. Journal of Nuclear Medicine,2016(-):-.
APA Zhenhua Hu.,Mingxuan Zhao.,Yawei Qu.,Xiaojun Zhang.,Mingru Zhang.,...&Jie Tian.(2016).In vivo three-dimensional radiopharmaceutical excited fluorescence tomography(已录用,待发表).Journal of Nuclear Medicine(-),-.
MLA Zhenhua Hu,et al."In vivo three-dimensional radiopharmaceutical excited fluorescence tomography(已录用,待发表)".Journal of Nuclear Medicine .-(2016):-.
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