Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
In vivo three-dimensional radiopharmaceutical excited fluorescence tomography(已录用,待发表) | |
Zhenhua Hu; Mingxuan Zhao; Yawei Qu; Xiaojun Zhang; Mingru Zhang; Muhan Liu; Hongbo Guo; Zeyu Zhang; Jing Wang; Weidong Yang; Jie Tian | |
发表期刊 | Journal of Nuclear Medicine |
2016 | |
期号 | -页码:- |
其他摘要 |
Cerenkov luminescence imaging (CLI) can image radiopharmaceuticals using
high-sensitivity charge coupled device (CCD) camera. However, Cerenkov
luminescence (CL) emitted from the radiopharmaceuticals is weak and has low
penetration depth in biological tissues, which severely limits the sensitivity and
accuracy of CLI. This study presents the three-dimensional (3D) radiopharmaceutical
excited fluorescence tomography (REFT) using europium oxide (EO) nanoparticles,
which enhances the CL signal intensity, improves the penetration depth, and obtains
more accurate 3D distribution of radiopharmaceuticals. Methods: The enhanced
optical signals of various radiopharmaceuticals (including Na 131 I,
18 F-FDG, 68 GaCl 3 ,
Na 99m TcO 4 ) by EO nanoparticles were detected in vitro. The location and 3D
distribution of the radiopharmaceuticals of REFT were then reconstructed and
compared with those of Cerenkov luminescence tomography (CLT) through the
experiments of the phantom, artificial source-implanted mouse models, and mice
bearing hepatocellular carcinomas (HCCs). Results: The mixture of 68 GaCl 3 and EO
nanoparticles possessed the strongest optical signals compared with the other mixtures.
The in vitro phantom and implanted mouse studies showed that REFT revealed more
accurate 3D distribution of
68 GaCl 3 . REFT can detected more tumors than small
animal positron emission tomography (PET) in HCC bearing mice and achieved more
accurate 3D distribution information compared with CLT. Conclusion: REFT with
EO nanoparticles significantly improves accuracy of localization of
radiopharmaceuticals and can precisely localize the tumor in vivo. |
关键词 | Radiopharmaceutical Excitation Fluorescence Tomography (Reft) Cerenkov Luminescence Imaging (Cli) Radionuclides Hepatocellular Carcinoma (Hcc) Pet |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/11998 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Jing Wang |
推荐引用方式 GB/T 7714 | Zhenhua Hu,Mingxuan Zhao,Yawei Qu,等. In vivo three-dimensional radiopharmaceutical excited fluorescence tomography(已录用,待发表)[J]. Journal of Nuclear Medicine,2016(-):-. |
APA | Zhenhua Hu.,Mingxuan Zhao.,Yawei Qu.,Xiaojun Zhang.,Mingru Zhang.,...&Jie Tian.(2016).In vivo three-dimensional radiopharmaceutical excited fluorescence tomography(已录用,待发表).Journal of Nuclear Medicine(-),-. |
MLA | Zhenhua Hu,et al."In vivo three-dimensional radiopharmaceutical excited fluorescence tomography(已录用,待发表)".Journal of Nuclear Medicine .-(2016):-. |
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