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Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder
Cai, Chenxi1,2; Yuan, Kai1,2; Yin, Junsen1,2; Feng, Dan1,2; Bi, Yanzhi1,2; Li, Yangding1,2; Yu, Dahua3; Jin, Chenwang4; Qin, Wei1,2; Tian, Jie1,2,5
AbstractInternet gaming disorder (IGD), identified in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) Section III as a condition warranting more clinical research, may be associated with impaired cognitive control. Previous IGD-related studies had revealed structural abnormalities in the prefrontal cortex, an important part of prefrontal-striatal circuits, which play critical roles in cognitive control. However, little is known about the relationship between the striatal nuclei (caudate, putamen, and nucleus accumbens) volumes and cognitive control deficit in individuals with IGD. Twenty-seven adolescents with IGD and 30 age-,gender-and education-matched healthy controls participated in this study. The volume differences of the striatum were assessed by measuring subcortical volume in FreeSurfer. Meanwhile, the Stroop task was used to detect cognitive control deficits. Correlation analysis was used to investigate the relationship between striatal volumes and performance in the Stroop task as well as severity in IGD. Relative to controls, the IGD committed more incongruent condition response errors during the Stroop task and showed increased volumes of dorsal striatum (caudate) and ventral striatum (nucleus accumbens). In addition, caudate volume was correlated with Stroop task performance and nucleus accumbens (NAc) volume was associated with the internet addiction test (IAT) score in the IGD group. The increased volumes of the right caudate and NAc and their association with behavioral characteristics (i.e., cognitive control and severity) in IGD were detected in the present study. Our findings suggest that the striatum may be implicated in the underlying pathophysiology of IGD.
KeywordCognitive Control Internet Gaming Disorder (Igd) Striatum Color-word Stroop Task Structural Magnetic Resonance Imaging
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationProject for the National Key Basic Research and Development Program(2014CB543203 ; National Natural Science Foundation of China(81401478 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities(8002-72125760 ; Natural Science Foundation of Inner Mongolia(2012MS0908) ; China Post- doctoral Science Foundation(2014 M552416) ; 2011CB707700 ; 81401488 ; 8002-72135767 ; 2012CB518501) ; 81227901 ; 8002-72145760) ; 81271644 ; 81271546 ; 81101036 ; 81101108 ; 31200837 ; 81301281)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000377829500002
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorTian, Jie
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Inner Mongolia Key Lab Pattern Recognit & Intelli, Baotou 014010, Inner Mongolia, Peoples R China
4.Xi An Jiao Tong Univ, Dept Med Imaging, Affiliated Hosp 1, Coll Med, Xian 710061, Shaanxi, Peoples R China
5.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Cai, Chenxi,Yuan, Kai,Yin, Junsen,et al. Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder[J]. BRAIN IMAGING AND BEHAVIOR,2016,10(1):12-20.
APA Cai, Chenxi.,Yuan, Kai.,Yin, Junsen.,Feng, Dan.,Bi, Yanzhi.,...&Tian, Jie.(2016).Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder.BRAIN IMAGING AND BEHAVIOR,10(1),12-20.
MLA Cai, Chenxi,et al."Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder".BRAIN IMAGING AND BEHAVIOR 10.1(2016):12-20.
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