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Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas
Fan, Xing1,2; Wang, Yinyan1,2; Liu, Yong3; Liu, Xing1; Zhang, Chuanbao2; Wang, Lei1; Li, Shaowu4; Ma, Jun5; Jiang, Tao1,2,6
Source PublicationJOURNAL OF NEURO-ONCOLOGY
2016-07-01
Volume128Issue:3Pages:455-462
SubtypeArticle
AbstractHuman telomerase reverse transcriptase (TERT) promoter mutations are important genetic alterations in many kinds of human malignancies, including glioma. The current study aimed to investigate the anatomical specificity of TERT promoter mutations in glioblastomas (GBMs). Clinical information and preoperative magnetic resonance images of 203 patients with GBMs were reviewed. TERT promoter mutation status was assessed by Sanger sequencing in all cases. Tumor lesions were manually segmented and then registered to a standard brain atlas. Then the specific brain regions associated with TERT promoter mutation status were subsequently identified by voxel-based regression analysis. TERT promoter mutations were detected in 94 (46.3 %) of the 203 patients. Voxel-based statistical analysis demonstrated that GBMs with TERT promoter mutations were much more likely to locate in the right temporal lobe, while those with wild-type TERT promoters were more likely to occur in the anterior region of the right lateral ventricle. No significant difference was found in the lesion volumes of the T2-identified tumor or in the contrast enhancement areas between the two groups. The current study demonstrated the anatomic specificity of TERT promoter mutation status in GBM. These findings may provide new insight into the molecular classification of GBM and further our understanding of the associations between tumor-specific molecular alterations and tumor location.
KeywordGlioblastoma Telomerase Reverse Transcriptase Anatomical Specificity Voxel-based Mapping
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11060-016-2132-y
WOS KeywordTERT PROMOTER ; ADJUVANT TEMOZOLOMIDE ; MALIGNANT GLIOMAS ; GENETIC PATHWAYS ; TUMORS ; EXPRESSION ; MULTIFORME ; RADIOTHERAPY ; NEUROANATOMY ; CONCOMITANT
Indexed BySCI
Language英语
Funding OrganizationNational 973 Programs(2015CB755500 ; 2011CB707804)
WOS Research AreaOncology ; Neurosciences & Neurology
WOS SubjectOncology ; Clinical Neurology
WOS IDWOS:000377915200010
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/12049
Collection脑网络组研究中心
Affiliation1.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
2.Capital Med Univ, Beijing Neurosurg Inst, Dept Neuropathol, 6 Tiantanxili, Beijing 100050, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
4.Capital Med Univ, Beijing Neurosurg Inst, Dept Funct Neuroradiol, Beijing 100050, Peoples R China
5.Capital Med Univ, Beijing Tiantan Hosp, Dept Neuroradiol, Beijing 100050, Peoples R China
6.Beijing Inst Brain Disorders, Ctr Brain Tumor, Beijing 100069, Peoples R China
Recommended Citation
GB/T 7714
Fan, Xing,Wang, Yinyan,Liu, Yong,et al. Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas[J]. JOURNAL OF NEURO-ONCOLOGY,2016,128(3):455-462.
APA Fan, Xing.,Wang, Yinyan.,Liu, Yong.,Liu, Xing.,Zhang, Chuanbao.,...&Jiang, Tao.(2016).Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas.JOURNAL OF NEURO-ONCOLOGY,128(3),455-462.
MLA Fan, Xing,et al."Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas".JOURNAL OF NEURO-ONCOLOGY 128.3(2016):455-462.
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