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Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas
Fan, Xing1,2; Wang, Yinyan1,2; Liu, Yong3; Liu, Xing1; Zhang, Chuanbao2; Wang, Lei1; Li, Shaowu4; Ma, Jun5; Jiang, Tao1,2,6
2016-07-01
发表期刊JOURNAL OF NEURO-ONCOLOGY
卷号128期号:3页码:455-462
文章类型Article
摘要Human telomerase reverse transcriptase (TERT) promoter mutations are important genetic alterations in many kinds of human malignancies, including glioma. The current study aimed to investigate the anatomical specificity of TERT promoter mutations in glioblastomas (GBMs). Clinical information and preoperative magnetic resonance images of 203 patients with GBMs were reviewed. TERT promoter mutation status was assessed by Sanger sequencing in all cases. Tumor lesions were manually segmented and then registered to a standard brain atlas. Then the specific brain regions associated with TERT promoter mutation status were subsequently identified by voxel-based regression analysis. TERT promoter mutations were detected in 94 (46.3 %) of the 203 patients. Voxel-based statistical analysis demonstrated that GBMs with TERT promoter mutations were much more likely to locate in the right temporal lobe, while those with wild-type TERT promoters were more likely to occur in the anterior region of the right lateral ventricle. No significant difference was found in the lesion volumes of the T2-identified tumor or in the contrast enhancement areas between the two groups. The current study demonstrated the anatomic specificity of TERT promoter mutation status in GBM. These findings may provide new insight into the molecular classification of GBM and further our understanding of the associations between tumor-specific molecular alterations and tumor location.
关键词Glioblastoma Telomerase Reverse Transcriptase Anatomical Specificity Voxel-based Mapping
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11060-016-2132-y
关键词[WOS]TERT PROMOTER ; ADJUVANT TEMOZOLOMIDE ; MALIGNANT GLIOMAS ; GENETIC PATHWAYS ; TUMORS ; EXPRESSION ; MULTIFORME ; RADIOTHERAPY ; NEUROANATOMY ; CONCOMITANT
收录类别SCI
语种英语
项目资助者National 973 Programs(2015CB755500 ; 2011CB707804)
WOS研究方向Oncology ; Neurosciences & Neurology
WOS类目Oncology ; Clinical Neurology
WOS记录号WOS:000377915200010
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/12049
专题脑网络组研究中心
作者单位1.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
2.Capital Med Univ, Beijing Neurosurg Inst, Dept Neuropathol, 6 Tiantanxili, Beijing 100050, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
4.Capital Med Univ, Beijing Neurosurg Inst, Dept Funct Neuroradiol, Beijing 100050, Peoples R China
5.Capital Med Univ, Beijing Tiantan Hosp, Dept Neuroradiol, Beijing 100050, Peoples R China
6.Beijing Inst Brain Disorders, Ctr Brain Tumor, Beijing 100069, Peoples R China
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Fan, Xing,Wang, Yinyan,Liu, Yong,et al. Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas[J]. JOURNAL OF NEURO-ONCOLOGY,2016,128(3):455-462.
APA Fan, Xing.,Wang, Yinyan.,Liu, Yong.,Liu, Xing.,Zhang, Chuanbao.,...&Jiang, Tao.(2016).Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas.JOURNAL OF NEURO-ONCOLOGY,128(3),455-462.
MLA Fan, Xing,et al."Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas".JOURNAL OF NEURO-ONCOLOGY 128.3(2016):455-462.
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