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White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study
Li, Xuan-yu1; Tang, Zhen-chao3; Sun, Yu1; Tian, Jie2; Liu, Zhen-yu2; Han, Ying1,4; Zhenyu Liu
2016-08-23
发表期刊ONCOTARGET
卷号7期号:34页码:54405-54414
文章类型Article
摘要
; Subjective cognitive decline (SCD) may be an at-risk stage of Alzheimer's disease (AD) occurring prior to amnestic mild cognitive impairment (aMCI). To examine white matter (WM) defects in SCD, diffusion images from 27 SCD (age=65.3+/-8.0), 35 aMCI (age=69.2+/-8.6) and 25 AD patients (age=68.3+/-9.4) and 37 normal controls (NC) (age=65.1+/-6.8) were compared using Tract-Based Spatial Statistics (TBSS). WM impairments common to the three patient groups were extracted, and fractional anisotropy (FA) values were averaged in each group. As compared to NC subjects, SCD patients displayed widespread WM alterations represented by decreased FA (p<0.05), increased mean diffusivity (MD; p<0.05), and increased radial diffusivity (RD; p<0.05). In addition, localized WM alterations showed increased axial diffusivity (AxD; p<0.05) similar to what was observed in aMCI and AD patients (p<0.05). In the shared WM impairment tracts, SCD patients had FA values between the NC group and the other two patient groups. In the NC and SCD groups, the AVLT-delayed recall score correlated with higher AxD (r=-0.333, p=0.045), MD (r=-0.351, p=0.03) and RD (r=-0.353, p=0.025). In both the aMCI and AD groups the diffusion parameters were highly correlated with cognitive scores. Our study suggests that SCD patients present with widespread WM changes, which may contribute to the early memory decline they experience.
关键词Subjective Cognitive Decline Diffusion Tensor Imaging Preclinical Alzheimer's Disease White Matter Tract-based Spatial Statistics
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.18632/oncotarget.10091
关键词[WOS]ALZHEIMERS-DISEASE ; MEMORY IMPAIRMENT ; CEREBROSPINAL-FLUID ; WATER DIFFUSION ; FUNCTIONAL MRI ; BRAIN ; COMPLAINTS ; ATROPHY ; MCI ; DYSMYELINATION
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(31371007 ; Beijing Municipal Science & Technology Commission(Z131100006813022) ; Kallikrein Medical Research Program(201206006) ; National Key Department of Neurology - Chinese Health and Family Planning Committee ; 81430037 ; 30970823 ; 81501549)
WOS研究方向Oncology ; Cell Biology
WOS类目Oncology ; Cell Biology
WOS记录号WOS:000385435000026
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/12108
专题中国科学院分子影像重点实验室
通讯作者Zhenyu Liu
作者单位1.Capital Med Univ, XuanWu Hosp, Dept Neurol, Beijing 100053, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Shandong Univ, Sch Mech Elect & Informat Engn, Weihai 264209, Shandong, Peoples R China
4.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100053, Peoples R China
推荐引用方式
GB/T 7714
Li, Xuan-yu,Tang, Zhen-chao,Sun, Yu,et al. White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study[J]. ONCOTARGET,2016,7(34):54405-54414.
APA Li, Xuan-yu.,Tang, Zhen-chao.,Sun, Yu.,Tian, Jie.,Liu, Zhen-yu.,...&Zhenyu Liu.(2016).White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study.ONCOTARGET,7(34),54405-54414.
MLA Li, Xuan-yu,et al."White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study".ONCOTARGET 7.34(2016):54405-54414.
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