CASIA OpenIR  > 中国科学院分子影像重点实验室
A multivariate pattern analysis study of the HIV-related white matter anatomical structural connections alterations
Tang Zhenchao; Liu ZY(刘振宇); Tian Jie
2017-02
Conference NameSPIE Medical Imaging
Source PublicationSPIE Medical Imaging
Conference Date11 - 16 February 2017
Conference PlaceOrlando, Florida, United States
AbstractIt’s widely known that HIV infection would cause white matter integrity impairments. Nevertheless, it is still unclear that how the white matter anatomical structural connections are affected by HIV infection. In the current study, we employed a multivariate pattern analysis to explore the HIV-related white matter connections alterations. Forty antiretroviral-therapy-naïve HIV patients and thirty healthy controls were enrolled. Firstly, an Automatic Anatomical Label (AAL) atlas based white matter structural network, a 90 × 90 FA-weighted matrix, was constructed for each subject. Then, the white matter connections deprived from the structural network were entered into a lasso-logistic regression model to perform HIV-control group classification. Using leave one out cross validation, a classification accuracy (ACC) of 90% (P=0.002) and areas under the receiver operating characteristic curve (AUC) of 0.96 was obtained in the classification model. This result indicated that the white matter anatomical structural connections contributed greatly to HIV-control group classification, providing solid evidence that the white matter connections were affected by HIV infection. Specially, 11 white matter structural connections were selected in the classification model, mainly crossing the regions of frontal lobe, Cingulum, Hippocampus, and Thalamus, which were repeatedly reported damaged in previous HIV study. This might suggested that the white matter connections adjacent to the HIV-related impaired regions were prone to be damaged.
KeywordHuman Immunodeficiency Virus
Document Type会议论文
Identifierhttp://ir.ia.ac.cn/handle/173211/12110
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian Jie
Recommended Citation
GB/T 7714
Tang Zhenchao,Liu ZY,Tian Jie. A multivariate pattern analysis study of the HIV-related white matter anatomical structural connections alterations[C],2017.
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