CASIA OpenIR  > 脑网络组研究中心
The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects
Zheng, Fanfan1; Cui, Yue1,2; Yan, Hao3,4,5; Liu, Bing1,2; Jiang, Tianzi1,2,6,7; Tianzi Jiang
2016-09-29
发表期刊SCIENTIFIC REPORTS
卷号6期号:6页码:34298
文章类型Article
摘要Schizophrenia is a highly heritable disorder with multiple susceptibility genes. Previously, we identified CACNA1C rs2007044 as a new risk locus for schizophrenia, with the minor allele G as risk allele. This association was recently validated by a powerful genome-wide association study. However, the underlying neural mechanisms remain unclear. Therefore, we tested whether the risk allele has an influence on cortical surface area and thickness in a sample of schizophrenia patients and healthy controls. We found significant genotype by diagnosis interactions on cortical surface area, but not thickness, in the right dorsolateral prefrontal cortex and the left superior parietal cortex, both of which are key components of the central executive network. Moreover, the surface areas of both regions were inversely correlated with PANSS negative scores in AA homogeneous patients but not in G-carriers. This is the first study to describe the influence of the new genome-wide supported schizophrenia risk variant on cortical morphology. Our data revealed a significant genetic effect of cortical surface area in pivotal brain regions, which have been implicated in the pathophysiology of schizophrenia, possibly via their involvement in cognitive functions. These results yield new insights into the potential neural mechanisms linking CACNA1C to the risk of schizophrenia.
其他摘要英文摘要
关键词Schizophrenia Cortical Surface
WOS标题词Science & Technology
DOI10.1038/srep34298
关键词[WOS]1ST EPISODE SCHIZOPHRENIA ; DORSOLATERAL PREFRONTAL CORTEX ; HUMAN CEREBRAL-CORTEX ; GRAY-MATTER VOLUME ; WORKING-MEMORY ; SURFACE-AREA ; CHINESE POPULATION ; CALCIUM REGULATION ; BIPOLAR DISORDER ; CA2+ INFLUX
收录类别SCI
语种英语
项目资助者Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(81601176 ; 91132301 ; 91232718 ; 91432302)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000384183600002
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/12118
专题脑网络组研究中心
通讯作者Tianzi Jiang
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
3.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China
4.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
5.Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
7.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Fanfan,Cui, Yue,Yan, Hao,et al. The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects[J]. SCIENTIFIC REPORTS,2016,6(6):34298.
APA Zheng, Fanfan,Cui, Yue,Yan, Hao,Liu, Bing,Jiang, Tianzi,&Tianzi Jiang.(2016).The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects.SCIENTIFIC REPORTS,6(6),34298.
MLA Zheng, Fanfan,et al."The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects".SCIENTIFIC REPORTS 6.6(2016):34298.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
srep34298.pdf(627KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zheng, Fanfan]的文章
[Cui, Yue]的文章
[Yan, Hao]的文章
百度学术
百度学术中相似的文章
[Zheng, Fanfan]的文章
[Cui, Yue]的文章
[Yan, Hao]的文章
必应学术
必应学术中相似的文章
[Zheng, Fanfan]的文章
[Cui, Yue]的文章
[Yan, Hao]的文章
相关权益政策
暂无数据
收藏/分享
文件名: srep34298.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。