| The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects | |
Zheng, Fanfan1 ; Cui, Yue1,2; Yan, Hao3,4,5; Liu, Bing1,2; Jiang, Tianzi1,2,6,7; Tianzi Jiang
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| 发表期刊 | SCIENTIFIC REPORTS
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| 2016-09-29 | |
| 卷号 | 6期号:6页码:34298 |
| 文章类型 | Article |
| 摘要 | Schizophrenia is a highly heritable disorder with multiple susceptibility genes. Previously, we identified CACNA1C rs2007044 as a new risk locus for schizophrenia, with the minor allele G as risk allele. This association was recently validated by a powerful genome-wide association study. However, the underlying neural mechanisms remain unclear. Therefore, we tested whether the risk allele has an influence on cortical surface area and thickness in a sample of schizophrenia patients and healthy controls. We found significant genotype by diagnosis interactions on cortical surface area, but not thickness, in the right dorsolateral prefrontal cortex and the left superior parietal cortex, both of which are key components of the central executive network. Moreover, the surface areas of both regions were inversely correlated with PANSS negative scores in AA homogeneous patients but not in G-carriers. This is the first study to describe the influence of the new genome-wide supported schizophrenia risk variant on cortical morphology. Our data revealed a significant genetic effect of cortical surface area in pivotal brain regions, which have been implicated in the pathophysiology of schizophrenia, possibly via their involvement in cognitive functions. These results yield new insights into the potential neural mechanisms linking CACNA1C to the risk of schizophrenia. |
| 其他摘要 | 英文摘要 |
| 关键词 | Schizophrenia Cortical Surface |
| WOS标题词 | Science & Technology |
| DOI | 10.1038/srep34298 |
| 关键词[WOS] | 1ST EPISODE SCHIZOPHRENIA ; DORSOLATERAL PREFRONTAL CORTEX ; HUMAN CEREBRAL-CORTEX ; GRAY-MATTER VOLUME ; WORKING-MEMORY ; SURFACE-AREA ; CHINESE POPULATION ; CALCIUM REGULATION ; BIPOLAR DISORDER ; CA2+ INFLUX |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(81601176 ; 91132301 ; 91232718 ; 91432302) |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000384183600002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/12118 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 通讯作者 | Tianzi Jiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 3.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China 4.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China 5.Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia 7.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu, Peoples R China |
| 第一作者单位 | 中国科学院自动化研究所 |
| 推荐引用方式 GB/T 7714 | Zheng, Fanfan,Cui, Yue,Yan, Hao,et al. The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects[J]. SCIENTIFIC REPORTS,2016,6(6):34298. |
| APA | Zheng, Fanfan,Cui, Yue,Yan, Hao,Liu, Bing,Jiang, Tianzi,&Tianzi Jiang.(2016).The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects.SCIENTIFIC REPORTS,6(6),34298. |
| MLA | Zheng, Fanfan,et al."The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects".SCIENTIFIC REPORTS 6.6(2016):34298. |
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| srep34298.pdf（627KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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