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The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects
Zheng, Fanfan1; Cui, Yue1,2; Yan, Hao3,4,5; Liu, Bing1,2; Jiang, Tianzi1,2,6,7; Tianzi Jiang
Source PublicationSCIENTIFIC REPORTS
2016-09-29
Volume6Issue:6Pages:34298
SubtypeArticle
AbstractSchizophrenia is a highly heritable disorder with multiple susceptibility genes. Previously, we identified CACNA1C rs2007044 as a new risk locus for schizophrenia, with the minor allele G as risk allele. This association was recently validated by a powerful genome-wide association study. However, the underlying neural mechanisms remain unclear. Therefore, we tested whether the risk allele has an influence on cortical surface area and thickness in a sample of schizophrenia patients and healthy controls. We found significant genotype by diagnosis interactions on cortical surface area, but not thickness, in the right dorsolateral prefrontal cortex and the left superior parietal cortex, both of which are key components of the central executive network. Moreover, the surface areas of both regions were inversely correlated with PANSS negative scores in AA homogeneous patients but not in G-carriers. This is the first study to describe the influence of the new genome-wide supported schizophrenia risk variant on cortical morphology. Our data revealed a significant genetic effect of cortical surface area in pivotal brain regions, which have been implicated in the pathophysiology of schizophrenia, possibly via their involvement in cognitive functions. These results yield new insights into the potential neural mechanisms linking CACNA1C to the risk of schizophrenia.
Other Abstract英文摘要
KeywordSchizophrenia Cortical Surface
WOS HeadingsScience & Technology
DOI10.1038/srep34298
WOS Keyword1ST EPISODE SCHIZOPHRENIA ; DORSOLATERAL PREFRONTAL CORTEX ; HUMAN CEREBRAL-CORTEX ; GRAY-MATTER VOLUME ; WORKING-MEMORY ; SURFACE-AREA ; CHINESE POPULATION ; CALCIUM REGULATION ; BIPOLAR DISORDER ; CA2+ INFLUX
Indexed BySCI
Language英语
Funding OrganizationStrategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(81601176 ; 91132301 ; 91232718 ; 91432302)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000384183600002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/12118
Collection脑网络组研究中心
Corresponding AuthorTianzi Jiang
Affiliation1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
3.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China
4.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
5.Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
7.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Fanfan,Cui, Yue,Yan, Hao,et al. The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects[J]. SCIENTIFIC REPORTS,2016,6(6):34298.
APA Zheng, Fanfan,Cui, Yue,Yan, Hao,Liu, Bing,Jiang, Tianzi,&Tianzi Jiang.(2016).The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects.SCIENTIFIC REPORTS,6(6),34298.
MLA Zheng, Fanfan,et al."The effects of a genome-wide supported variant in the CACNA1C gene on cortical morphology in schizophrenia patients and healthy subjects".SCIENTIFIC REPORTS 6.6(2016):34298.
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