CASIA OpenIR  > 中国科学院分子影像重点实验室
Novel l(2,1)-norm optimization method for fluorescence molecular tomography reconstruction
Jiang, Shixin1; Liu, Jie1; An, Yu1; Zhang, Guanglei1; Ye, Jinzuo2; Mao, Yamin2; He, Kunshan2; Chi, Chongwei2,3; Tian, Jie2,3
Source PublicationBIOMEDICAL OPTICS EXPRESS
2016-06-01
Volume7Issue:6Pages:2342-2359
SubtypeArticle
AbstractFluorescence molecular tomography (FMT) is a promising tomographic method in preclinical research, which enables noninvasive real-time three-dimensional (3-D) visualization for in vivo studies. The ill-posedness of the FMT reconstruction problem is one of the many challenges in the studies of FMT. In this paper, we propose a l(2,1)-norm optimization method using a priori information, mainly the structured sparsity of the fluorescent regions for FMT reconstruction. Compared to standard sparsity methods, the structured sparsity methods are often superior in reconstruction accuracy since the structured sparsity utilizes correlations or structures of the reconstructed image. To solve the problem effectively, the Nesterov's method was used to accelerate the computation. To evaluate the performance of the proposed l(2,1)-norm method, numerical phantom experiments and in vivo mouse experiments are conducted. The results show that the proposed method not only achieves accurate and desirable fluorescent source reconstruction, but also demonstrates enhanced robustness to noise. (C) 2016 Optical Society of America
KeywordImage Reconstruction Techniques Spectroscopy Fluorescence And Luminescence Tomography
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1364/BOE.7.002342
WOS KeywordDIFFUSE OPTICAL TOMOGRAPHY ; ELEMENT BASED TOMOGRAPHY ; IMAGE-RECONSTRUCTION ; BIOLUMINESCENCE TOMOGRAPHY ; SPARSITY REGULARIZATION ; ALGORITHM ; LIGHT ; INFORMATION ; MICROSCOPY ; TISSUE
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81571836 ; Fundamental Research Funds for the Central Universities(2015JBM026) ; China Postdoctoral Science Foundation(2015M570032 ; Beijing Natural Science Foundation(7164270 ; Open Research Project from SKLMCCS(20150103) ; 81227901 ; 2015T80155) ; 20140491524) ; 61231004 ; 61501462)
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000377514000023
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Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/12187
Collection中国科学院分子影像重点实验室
Corresponding AuthorLiu, Jie
Affiliation1.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Dept Biomed Engn, 3 Shangyuancun, Beijing 100044, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Shixin,Liu, Jie,An, Yu,et al. Novel l(2,1)-norm optimization method for fluorescence molecular tomography reconstruction[J]. BIOMEDICAL OPTICS EXPRESS,2016,7(6):2342-2359.
APA Jiang, Shixin.,Liu, Jie.,An, Yu.,Zhang, Guanglei.,Ye, Jinzuo.,...&Tian, Jie.(2016).Novel l(2,1)-norm optimization method for fluorescence molecular tomography reconstruction.BIOMEDICAL OPTICS EXPRESS,7(6),2342-2359.
MLA Jiang, Shixin,et al."Novel l(2,1)-norm optimization method for fluorescence molecular tomography reconstruction".BIOMEDICAL OPTICS EXPRESS 7.6(2016):2342-2359.
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