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Distinct Changes in Functional Connectivity in Posteromedial Cortex Subregions during the Progress of Alzheimer's Disease
Wu, Yan1; Zhang, Yaqin1; Liu, Yong2,3; Liu, Jieqiong4; Duan, Yunyun5; Wei, Xuehu1; Zhuo, Junjie1; Li, Kuncheng5; Zhang, Xinqin4; Yu, Chunshui5,6; Wang, Jiaojian1; Jiang, Tianzi1,2,3,7,8
2016-04-12
发表期刊FRONTIERS IN NEUROANATOMY
卷号10
文章类型Article
摘要Alzheimers disease (AD) is a progressive neurodegenerative disorder which causes dementia, especially in the elderly. The posteromedial cortex (PMC), which consists of several subregions involved in distinct functions, is one of the critical regions associated with the progression and severity of AD. However, previous studies always ignored the heterogeneity of the PMC and focused on one stage of AD. Using resting-state functional magnetic resonance imaging, we studied the respective alterations of each subregion within the PMC along the progression of AD. Our data set consisted of 21 healthy controls, 18 patients with mild cognitive impairment (MCI), 17 patients with mild AD (mAD), and 18 patients with severe AD (sAD). We investigated the functional alterations of each subregion within the PMC in different stages of AD. We found that subregions within the PMC have differential vulnerability in AD. Disruptions in functional connectivity began in the transition area between the precuneus and the posterior cingulate cortex (PCC) and then extended to other subregions of the PMC. In addition, each of these subregions was associated with distinct alterations in the functional networks that we were able to relate to AD. Our research demonstrated functional changes within the PMC in the progression of AD and may elucidate potential biomarkers for clinical applications.
关键词Alzheimer'sdisease Posteromedial Cortex Functionalconnectivity Network Subregions
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.3389/fnana.2016.00041
关键词[WOS]MILD COGNITIVE IMPAIRMENT ; POSTERIOR CINGULATE CORTEX ; RESTING-STATE FMRI ; DIAGNOSIS ; NETWORK ; ARCHITECTURE ; PRECUNEUS ; CRITERIA
收录类别SCI
语种英语
项目资助者Natural Science Foundation of China(91432302 ; Youth Innovation Promotion Association CAS(2014119) ; Natural Science Foundation of Beijing(7152096) ; Beijing Nova Program(Z1511000003150112) ; 81471120 ; 81571062 ; 31500867)
WOS研究方向Anatomy & Morphology ; Neurosciences & Neurology
WOS类目Anatomy & Morphology ; Neurosciences
WOS记录号WOS:000373881200001
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/12195
专题脑网络组研究中心
作者单位1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
2.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
4.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
5.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
6.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China
7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
8.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing, Peoples R China
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Wu, Yan,Zhang, Yaqin,Liu, Yong,et al. Distinct Changes in Functional Connectivity in Posteromedial Cortex Subregions during the Progress of Alzheimer's Disease[J]. FRONTIERS IN NEUROANATOMY,2016,10.
APA Wu, Yan.,Zhang, Yaqin.,Liu, Yong.,Liu, Jieqiong.,Duan, Yunyun.,...&Jiang, Tianzi.(2016).Distinct Changes in Functional Connectivity in Posteromedial Cortex Subregions during the Progress of Alzheimer's Disease.FRONTIERS IN NEUROANATOMY,10.
MLA Wu, Yan,et al."Distinct Changes in Functional Connectivity in Posteromedial Cortex Subregions during the Progress of Alzheimer's Disease".FRONTIERS IN NEUROANATOMY 10(2016).
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