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Core brain networks interactions and cognitive control in internet gaming disorder individuals in late adolescence/early adulthood
Yuan, Kai1,2; Qin, Wei1,2; Yu, Dahua3; Bi, Yanzhi1,2; Xing, Lihong1,2; Jin, Chenwang4; Tian, Jie1,2,5
AbstractRegardless of whether it is conceptualized as a behavioral addiction or an impulse-control disorder, internet gaming disorder (IGD) has been speculated to be associated with impaired cognitive control. Efficient cognitive behavior involves the coordinated activity of large-scale brain networks, however, whether the interactions among these networks during resting state modulated cognitive control behavior in IGD adolescents remain unclear. Twenty-eight IGD adolescents and twenty-five age-, gender-, and education-matched healthy controls participated in our study. Stroop color-word task was conducted to evaluate the cognitive control deficits in IGD adolescents. Functional connectivity and Granger Causal Analysis were employed to investigate the functional and effective connections within and between the salience, central executive, and default mode networks. Meanwhile, diffusion tensor imaging was used to assess the structural integrity of abnormal network connections. The abnormal functional connectivity within central executive networks and effective connectivity within salience network in IGD adolescents were detected. Moreover, the inefficient interactions between these two brain networks were observed. In addition, we identified reduced fractional anisotropy in salience network, right central executive network tracts, and between-network (the anterior cingulate cortex-right dorsolateral prefrontal cortex tracts) pathways in IGD individuals. Notably, we observed a significant correlation between the effective and structural connection from salience network to central executive network and the number of errors during incongruent condition in Stroop task in both IGD and control subjects. Our results suggested that impaired cognitive control in IGD adolescents is likely to be mediated through the abnormal interactions and structural connection between intrinsic large-scale brain networks.
KeywordInternet Gaming Disorder Salience Network Central Executive Network Default Mode Network Cognitive Control
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationProject for the National Key Basic Research and Development Program (973)(2014CB543203 ; National Natural Science Foundation of China(81227901 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities ; Natural Science Foundation of Inner Mongolia(2012MS0908) ; China Postdoctoral Science Foundation(2014M552416) ; 2011CB707700 ; 81271644 ; 2012CB518501) ; 81271546 ; 81101036 ; 81101108 ; 31200837 ; 81030027 ; 81301281 ; 81401488 ; 81401478 ; 81471737 ; 81471811 ; 81471738 ; 61401346)
WOS Research AreaAnatomy & Morphology ; Neurosciences & Neurology
WOS SubjectAnatomy & Morphology ; Neurosciences
WOS IDWOS:000373801400015
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Document Type期刊论文
Corresponding AuthorTian, Jie
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Informat Proc Lab, Baotou 014010, Inner Mongolia, Peoples R China
4.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Med Imaging, Xian 710061, Shaanxi, Peoples R China
5.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Kai,Qin, Wei,Yu, Dahua,et al. Core brain networks interactions and cognitive control in internet gaming disorder individuals in late adolescence/early adulthood[J]. BRAIN STRUCTURE & FUNCTION,2016,221(3):1427-1442.
APA Yuan, Kai.,Qin, Wei.,Yu, Dahua.,Bi, Yanzhi.,Xing, Lihong.,...&Tian, Jie.(2016).Core brain networks interactions and cognitive control in internet gaming disorder individuals in late adolescence/early adulthood.BRAIN STRUCTURE & FUNCTION,221(3),1427-1442.
MLA Yuan, Kai,et al."Core brain networks interactions and cognitive control in internet gaming disorder individuals in late adolescence/early adulthood".BRAIN STRUCTURE & FUNCTION 221.3(2016):1427-1442.
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