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Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy
Shi, Yiwen1; Peng, Dong2,3; Wang, Kun3; Chai, Xinyu1; Ren, Qiushi4; Tian, Jie2,3; Zhou, Chuanqing1
2016-05-01
发表期刊BIOMEDICAL OPTICS EXPRESS
卷号7期号:5页码:1830-1841
文章类型Article
摘要Optimizing contrast enhancement is essential for producing specific signals in biomedical imaging and therapy. The potential of using Au-core-Ag-shell nanorods (Au@Ag NRs) as a dual-functional theranostic contrast agent is demonstrated for effective cancer imaging and treatments. Due to its strong NIR absorption and high efficiency of photothermal conversion, effects of both photoacoustic tomography (PAT) and photothermal therapy (PTT) are enhanced significantly. The PAT signal grows by 45.3% and 82% in the phantom and in vivo experiments, respectively, when compared to those using Au NRs. In PTT, The maximum increase of tissue temperature treated with Au@Ag NRs is 22.8 degrees C, twice that with Au NRs. Results of the current study show the feasibility of using Au@Ag NRs for synergetic PAT with PTT. And it will enhance the potential application on real-time PAT guided PTT, which will greatly benefit the customized PTT treatment of cancer. (C) 2016 Optical Society of America
关键词Photoacoustic Imaging Photothermal Effects Image Enhancement Medical And Biological Imaging Nanomaterials
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1364/BOE.7.001830
关键词[WOS]COATED GOLD NANORODS ; SILVER NANOPARTICLES ; SHELL NANORODS ; CANCER-CELLS ; NANOSPHERES ; TOMOGRAPHY ; NANOSILVER ; RELEASE ; SURFACE ; IONS
收录类别SCI
语种英语
项目资助者National Basic Research Program of China(2010CB933903 ; National Natural Science Foundation of China(81171377 ; Chinese Academy of Sciences(YZ201359) ; 2014CB748600 ; 81470083) ; 2015CB755500)
WOS研究方向Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000374745200016
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/12216
专题中国科学院分子影像重点实验室
通讯作者Zhou, Chuanqing
作者单位1.Shanghai Jiao Tong Univ, Dept Biomed Engn, Shanghai 200240, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China
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Shi, Yiwen,Peng, Dong,Wang, Kun,et al. Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy[J]. BIOMEDICAL OPTICS EXPRESS,2016,7(5):1830-1841.
APA Shi, Yiwen.,Peng, Dong.,Wang, Kun.,Chai, Xinyu.,Ren, Qiushi.,...&Zhou, Chuanqing.(2016).Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy.BIOMEDICAL OPTICS EXPRESS,7(5),1830-1841.
MLA Shi, Yiwen,et al."Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy".BIOMEDICAL OPTICS EXPRESS 7.5(2016):1830-1841.
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