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Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy
Shi, Yiwen1; Peng, Dong2,3; Wang, Kun3; Chai, Xinyu1; Ren, Qiushi4; Tian, Jie2,3; Zhou, Chuanqing1
Source PublicationBIOMEDICAL OPTICS EXPRESS
2016-05-01
Volume7Issue:5Pages:1830-1841
SubtypeArticle
AbstractOptimizing contrast enhancement is essential for producing specific signals in biomedical imaging and therapy. The potential of using Au-core-Ag-shell nanorods (Au@Ag NRs) as a dual-functional theranostic contrast agent is demonstrated for effective cancer imaging and treatments. Due to its strong NIR absorption and high efficiency of photothermal conversion, effects of both photoacoustic tomography (PAT) and photothermal therapy (PTT) are enhanced significantly. The PAT signal grows by 45.3% and 82% in the phantom and in vivo experiments, respectively, when compared to those using Au NRs. In PTT, The maximum increase of tissue temperature treated with Au@Ag NRs is 22.8 degrees C, twice that with Au NRs. Results of the current study show the feasibility of using Au@Ag NRs for synergetic PAT with PTT. And it will enhance the potential application on real-time PAT guided PTT, which will greatly benefit the customized PTT treatment of cancer. (C) 2016 Optical Society of America
KeywordPhotoacoustic Imaging Photothermal Effects Image Enhancement Medical And Biological Imaging Nanomaterials
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1364/BOE.7.001830
WOS KeywordCOATED GOLD NANORODS ; SILVER NANOPARTICLES ; SHELL NANORODS ; CANCER-CELLS ; NANOSPHERES ; TOMOGRAPHY ; NANOSILVER ; RELEASE ; SURFACE ; IONS
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of China(2010CB933903 ; National Natural Science Foundation of China(81171377 ; Chinese Academy of Sciences(YZ201359) ; 2014CB748600 ; 81470083) ; 2015CB755500)
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000374745200016
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/12216
Collection中国科学院分子影像重点实验室
Corresponding AuthorZhou, Chuanqing
Affiliation1.Shanghai Jiao Tong Univ, Dept Biomed Engn, Shanghai 200240, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Shi, Yiwen,Peng, Dong,Wang, Kun,et al. Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy[J]. BIOMEDICAL OPTICS EXPRESS,2016,7(5):1830-1841.
APA Shi, Yiwen.,Peng, Dong.,Wang, Kun.,Chai, Xinyu.,Ren, Qiushi.,...&Zhou, Chuanqing.(2016).Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy.BIOMEDICAL OPTICS EXPRESS,7(5),1830-1841.
MLA Shi, Yiwen,et al."Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy".BIOMEDICAL OPTICS EXPRESS 7.5(2016):1830-1841.
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