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Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations
Liu, Bing1,2; Zhang, Xiaolong1,2; Cui, Yue1,2; Qin, Wen4; Tao, Yan1,2; Li, Jin1,2; Yu, Chunshui4; Jiang, Tianzi1,2,3,5,6
Source PublicationSCHIZOPHRENIA BULLETIN
2017-05-01
Volume43Issue:3Pages:673-680
SubtypeArticle
AbstractSchizophrenia is highly heritable, whereas the effect of each genetic variant is very weak. Since clinical heterogeneity and complexity of schizophrenia is high, considerable effort has been made to relate genetic variants to underlying neurobiological aspects of schizophrenia (endophenotypes). Given the polygenic nature of schizophrenia, our goal was to form a measure of additive genetic risk and explore its relationship to cortical morphology. Utilizing the data from a recent genome-wide association study that included nearly 37 000 cases of schizophrenia, we computed a polygenic risk score (PGRS) for each subject in 2 independent and healthy general populations. We then investigated the effect of polygenic risk for schizophrenia on cortical gyrification calculated from 3.0T structural imaging data in the discovery dataset (N = 315) and replication dataset (N = 357). We found a consistent effect of the polygenic risk for schizophrenia on cortical gyrification in the inferior parietal lobules in 2 independent general-population samples. A higher PGRS was significantly associated with a lower local gyrification index in the bilateral inferior parietal lobles, where case-control differences have been reported in previous studies on schizophrenia. Our findings strongly support the effectiveness of both PGRSs and endophenotypes in establishing the genetic architecture of psychiatry. Our findings may provide some implications regarding individual differences in the genetic risk for schizophrenia to cortical morphology and brain development.
KeywordSchizophrenia Polygenic Risk Score Cortical Gyrification Inferior Parietal Lobule
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1093/schbul/sbw051
WOS KeywordINFERIOR PARIETAL LOBULE ; GENOME-WIDE ASSOCIATION ; WORKING-MEMORY ; BIPOLAR DISORDER ; SURFACE ; FMRI ; CONNECTIVITY ; METAANALYSIS ; PERFORMANCE ; THICKNESS
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Key Basic Research and Development Program (973)(2011CB707800) ; Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91232718 ; 91132301)
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000398997900027
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/12380
Collection脑网络组研究中心
Corresponding AuthorJiang, Tianzi
Affiliation1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Zhongguancun East Rd 95, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
4.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Peoples R China
Recommended Citation
GB/T 7714
Liu, Bing,Zhang, Xiaolong,Cui, Yue,et al. Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations[J]. SCHIZOPHRENIA BULLETIN,2017,43(3):673-680.
APA Liu, Bing.,Zhang, Xiaolong.,Cui, Yue.,Qin, Wen.,Tao, Yan.,...&Jiang, Tianzi.(2017).Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations.SCHIZOPHRENIA BULLETIN,43(3),673-680.
MLA Liu, Bing,et al."Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations".SCHIZOPHRENIA BULLETIN 43.3(2017):673-680.
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