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Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations
Liu, Bing1,2; Zhang, Xiaolong1,2; Cui, Yue1,2; Qin, Wen4; Tao, Yan1,2; Li, Jin1,2; Yu, Chunshui4; Jiang, Tianzi1,2,3,5,6
2017-05-01
发表期刊SCHIZOPHRENIA BULLETIN
卷号43期号:3页码:673-680
文章类型Article
摘要Schizophrenia is highly heritable, whereas the effect of each genetic variant is very weak. Since clinical heterogeneity and complexity of schizophrenia is high, considerable effort has been made to relate genetic variants to underlying neurobiological aspects of schizophrenia (endophenotypes). Given the polygenic nature of schizophrenia, our goal was to form a measure of additive genetic risk and explore its relationship to cortical morphology. Utilizing the data from a recent genome-wide association study that included nearly 37 000 cases of schizophrenia, we computed a polygenic risk score (PGRS) for each subject in 2 independent and healthy general populations. We then investigated the effect of polygenic risk for schizophrenia on cortical gyrification calculated from 3.0T structural imaging data in the discovery dataset (N = 315) and replication dataset (N = 357). We found a consistent effect of the polygenic risk for schizophrenia on cortical gyrification in the inferior parietal lobules in 2 independent general-population samples. A higher PGRS was significantly associated with a lower local gyrification index in the bilateral inferior parietal lobles, where case-control differences have been reported in previous studies on schizophrenia. Our findings strongly support the effectiveness of both PGRSs and endophenotypes in establishing the genetic architecture of psychiatry. Our findings may provide some implications regarding individual differences in the genetic risk for schizophrenia to cortical morphology and brain development.
关键词Schizophrenia Polygenic Risk Score Cortical Gyrification Inferior Parietal Lobule
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1093/schbul/sbw051
关键词[WOS]INFERIOR PARIETAL LOBULE ; GENOME-WIDE ASSOCIATION ; WORKING-MEMORY ; BIPOLAR DISORDER ; SURFACE ; FMRI ; CONNECTIVITY ; METAANALYSIS ; PERFORMANCE ; THICKNESS
收录类别SCI ; SSCI
语种英语
项目资助者National Key Basic Research and Development Program (973)(2011CB707800) ; Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91232718 ; 91132301)
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000398997900027
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/12380
专题脑网络组研究中心
通讯作者Jiang, Tianzi
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Zhongguancun East Rd 95, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
4.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Peoples R China
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GB/T 7714
Liu, Bing,Zhang, Xiaolong,Cui, Yue,et al. Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations[J]. SCHIZOPHRENIA BULLETIN,2017,43(3):673-680.
APA Liu, Bing.,Zhang, Xiaolong.,Cui, Yue.,Qin, Wen.,Tao, Yan.,...&Jiang, Tianzi.(2017).Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations.SCHIZOPHRENIA BULLETIN,43(3),673-680.
MLA Liu, Bing,et al."Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations".SCHIZOPHRENIA BULLETIN 43.3(2017):673-680.
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