Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations | |
Liu, Bing1,2; Zhang, Xiaolong1,2; Cui, Yue1,2; Qin, Wen4; Tao, Yan1,2; Li, Jin1,2; Yu, Chunshui4; Jiang, Tianzi1,2,3,5,6 | |
发表期刊 | SCHIZOPHRENIA BULLETIN |
2017-05-01 | |
卷号 | 43期号:3页码:673-680 |
文章类型 | Article |
摘要 | Schizophrenia is highly heritable, whereas the effect of each genetic variant is very weak. Since clinical heterogeneity and complexity of schizophrenia is high, considerable effort has been made to relate genetic variants to underlying neurobiological aspects of schizophrenia (endophenotypes). Given the polygenic nature of schizophrenia, our goal was to form a measure of additive genetic risk and explore its relationship to cortical morphology. Utilizing the data from a recent genome-wide association study that included nearly 37 000 cases of schizophrenia, we computed a polygenic risk score (PGRS) for each subject in 2 independent and healthy general populations. We then investigated the effect of polygenic risk for schizophrenia on cortical gyrification calculated from 3.0T structural imaging data in the discovery dataset (N = 315) and replication dataset (N = 357). We found a consistent effect of the polygenic risk for schizophrenia on cortical gyrification in the inferior parietal lobules in 2 independent general-population samples. A higher PGRS was significantly associated with a lower local gyrification index in the bilateral inferior parietal lobles, where case-control differences have been reported in previous studies on schizophrenia. Our findings strongly support the effectiveness of both PGRSs and endophenotypes in establishing the genetic architecture of psychiatry. Our findings may provide some implications regarding individual differences in the genetic risk for schizophrenia to cortical morphology and brain development. |
关键词 | Schizophrenia Polygenic Risk Score Cortical Gyrification Inferior Parietal Lobule |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1093/schbul/sbw051 |
关键词[WOS] | INFERIOR PARIETAL LOBULE ; GENOME-WIDE ASSOCIATION ; WORKING-MEMORY ; BIPOLAR DISORDER ; SURFACE ; FMRI ; CONNECTIVITY ; METAANALYSIS ; PERFORMANCE ; THICKNESS |
收录类别 | SCI ; SSCI |
语种 | 英语 |
项目资助者 | National Key Basic Research and Development Program (973)(2011CB707800) ; Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91232718 ; 91132301) |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000398997900027 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/12380 |
专题 | 脑网络组研究 |
通讯作者 | Jiang, Tianzi |
作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Zhongguancun East Rd 95, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China 4.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia 6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Peoples R China |
第一作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室 |
通讯作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室 |
推荐引用方式 GB/T 7714 | Liu, Bing,Zhang, Xiaolong,Cui, Yue,et al. Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations[J]. SCHIZOPHRENIA BULLETIN,2017,43(3):673-680. |
APA | Liu, Bing.,Zhang, Xiaolong.,Cui, Yue.,Qin, Wen.,Tao, Yan.,...&Jiang, Tianzi.(2017).Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations.SCHIZOPHRENIA BULLETIN,43(3),673-680. |
MLA | Liu, Bing,et al."Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations".SCHIZOPHRENIA BULLETIN 43.3(2017):673-680. |
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