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Association between Tumor Heterogeneity and Progression-free Survival in Non-small Cell Lung Cancer Patients with EGFR Mutations Undergoing Tyrosine Kinase Inhibitors Therapy
Song, Jiangdian1,2; Dong, Di2; Huang, Yanqi3; Zang, Yali2; Liu, Zaiyi3; Tian, Jie2
2016
会议名称Annual International Conference of the IEEE Engineering in Medicine and Biology Society
会议录名称Annual International Conference of the IEEE Engineering in Medicine and Biology Society
会议日期2016-8
会议地点Orlando, Florida USA
摘要For non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations, current staging methods do not accurately predict the risk of disease recurrence after tyrosine kinase inhibitors (TKI) therapy. Developing a noninvasive method to predict whether individual could benefit from TKI therapy has great clinical significance. In this research, a radiomics approach was proposed to determine whether the tumor heterogeneity of NSCLC, which was measured by the texture on computed tomography (CT), could make an independent prediction of progression-free survival (PFS). A primary dataset contained 80 patients (median PFS, 9.5 months) with positive EGFR mutations and a validation dataset contained 72 NSCLC (median PFS, 10.2 months) patients were used for prognosis trial. The experiment results indicated that the features: “Cluster Prominence of Gray Level Co-occurrence” (hazard ratio [HR]: 2.13, 95% confidence interval [CI]: (1.33, 3.40), P = 0.010) and “Short Run High Gray Level Emphasis of Run Length” (HR: 2.43, 95%CI: (1.46, 4.05), P = 0.005) were significantly associated with PFS in the primary dataset, and these two texture features also make a consistent performance on the validation cohort. Our study further supported that the quantitative measurement of tumor heterogeneity can be associated with prognosis of NSCLC patients with EGFR mutation.
关键词Radiomics
文献类型会议论文
条目标识符http://ir.ia.ac.cn/handle/173211/12477
专题中国科学院分子影像重点实验室
通讯作者Zang, Yali; Liu, Zaiyi; Tian, Jie
作者单位1.Sino-Dutch Biomedical and Information Engineering School, Northeastern University
2.The Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences
3.Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences
推荐引用方式
GB/T 7714
Song, Jiangdian,Dong, Di,Huang, Yanqi,et al. Association between Tumor Heterogeneity and Progression-free Survival in Non-small Cell Lung Cancer Patients with EGFR Mutations Undergoing Tyrosine Kinase Inhibitors Therapy[C],2016.
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